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This cheevo may be a real pain to set up but latest updates helped us to get it thanks to move events that allows you to "remove a card from your deck", and a new boss relic that allow to remove 2 cards too.

In my opinion, the best character to play is the Ironclad. I managed to build an overpowered build.
My final 5 cards and the routine to play it were :
(at 1st turn)
1. Offering +
2. Inflame + (or Flex+ will work aswell)
3. Break the Limit +
4. Bash +
5. Heavy Blade +
(other turns)
(0. Flex+ if it's in your setup)
1. Break the Limit +
2. Heavy Blade +

To perfectly set this up, you'll require 1 relic that give 1 additional energy/turn (unless you play with Flex+ in place of Inflame+ and no additional energy will be required)
And as many relic that bring you power as you can afford.
Go for shops to remove Attacks/Defends from your deck & buy power relics.
Elites dont have to be avoided, I even forced my way to Elites from 2nd floor, to maximise my amount of relics and to optimize my way to shops/random events/rest camps.

There is another well known setup to complete the game thanks to an infinite loop of cards (such as Bash and 2 DropKicks), it works indeed but if you encouter Time Eater as final boss, the whole setup is lost. Not in my case, because I HAVE ENCOUNTERED Time Eater and I've rekt him in 2 turns...