Here is the full list of all 50 Deadpool achievements.
Bank a 300-hit combo
Get through Toxic River without falling into or touching the water and taking damage
Score a combo of 75 or more while fighting up the stairs at the 'Front Gates of EEEEEEEVIL!'
Make it across the floating debris without falling
Die 10 times in a row through the floating stairs
Complete five Gold Challenges
Complete a Gold- or Silver-tier Challenge while countering at least 25 times
Get from the studio lobby to the boardroom without dying in 5 minutes
Score a combo higher than 40 before they lock the elevators
Complete the game on Ultra-Violence! difficulty
Combo an entire wave on any Gold-tier Challenge map
Find 11 treasure chests in the darkness of the Tombs
Upgrade all weapons to max
Shoot everything from the Wheel of Insanity (Balloons and the Cow)
Take no damage on the waterslide
Use all three switches, defeat the two phasers, and chase after Vertigo within 60 seconds
Defeat Arclight while taking no damage from her slam attacks
Complete the Breach in 10 seconds
Complete 'Front Gates of EEEEEEEVIL!' from start to finish using only swords and pistols
Complete 'Front Gates of EEEEEEEVIL!' from start to finish without dying
Get a stealth kill with every melee weapon in Sinister's Lair without being detected
Complete 'Landed in Prison' without countering any attacks
In 'Genosha' reach the Fan Girl using only Hammers and Plasma Rifles
Shoot up the copier in the bridge offices
Collect all DP points and ammo in the bathroom
Playing with Deadpool's junk
Purchase all Player Upgrades
Complete the game on Veteran difficulty
Complete 'Front Gates of EEEEEEEVIL!'
Complete 'The Road to Victory'
Beat 'Death, Baby' while wearing the pirate hat
Complete 'Death, Baby'
Get a high score at the Carnival
Choose the patience option all the way through the line in the Carnival
Kill a total of 15 enemies by holding cooked grenades
Complete 'Landed in Prison'
Heh heh, good times
Stealth Kill Sinister, in the Prison, with the Sword!
Interact with all the ladies at the Shower Surprise Party room
Collect 100 tacos
Complete 'Genosha'
Kill 4 enemies in the Tower Plaza with stealth kills
Play WTF is Cable
Slap Wolverine a bunch of times
Complete 'Taking a Chance'
Set the Dialog Volume slider to zero
Complete 'Job One'
Make a thousand pancakes
Be pretty
Get off your well-toned bottom