Here is the full list of all 50 Deadpool achievements.
Bank a 300-hit combo
Kill a total of 15 enemies by holding cooked grenades
Complete the game on Ultra-Violence! difficulty
Complete 'Landed in Prison' without countering any attacks
Score a combo of 75 or more while fighting up the stairs at the 'Front Gates of EEEEEEEVIL!'
In 'Genosha' reach the Fan Girl using only Hammers and Plasma Rifles
Shoot up the copier in the bridge offices
Make it across the floating debris without falling
Use all three switches, defeat the two phasers, and chase after Vertigo within 60 seconds
Complete 'Front Gates of EEEEEEEVIL!' from start to finish without dying
Shoot everything from the Wheel of Insanity (Balloons and the Cow)
Get a stealth kill with every melee weapon in Sinister's Lair without being detected
Complete the Breach in 10 seconds
Find 11 treasure chests in the darkness of the Tombs
Take no damage on the waterslide
Get from the studio lobby to the boardroom without dying in 5 minutes
Score a combo higher than 40 before they lock the elevators
Defeat Arclight while taking no damage from her slam attacks
Kill 4 enemies in the Tower Plaza with stealth kills
Collect all DP points and ammo in the bathroom
Choose the patience option all the way through the line in the Carnival
Playing with Deadpool's junk
Complete 'Front Gates of EEEEEEEVIL!' from start to finish using only swords and pistols
Die 10 times in a row through the floating stairs
Upgrade all weapons to max
Set the Dialog Volume slider to zero
Purchase all Player Upgrades
Get through Toxic River without falling into or touching the water and taking damage
Complete the game on Veteran difficulty
Beat 'Death, Baby' while wearing the pirate hat
Complete 'Front Gates of EEEEEEEVIL!'
Complete 'The Road to Victory'
Slap Wolverine a bunch of times
Get a high score at the Carnival
Complete 'Death, Baby'
Interact with all the ladies at the Shower Surprise Party room
Complete 'Landed in Prison'
Stealth Kill Sinister, in the Prison, with the Sword!
Heh heh, good times
Collect 100 tacos
Complete 'Genosha'
Play WTF is Cable
Complete 'Taking a Chance'
Make a thousand pancakes
Complete 'Job One'
Get off your well-toned bottom
Be pretty
Complete five Gold Challenges
Complete a Gold- or Silver-tier Challenge while countering at least 25 times
Combo an entire wave on any Gold-tier Challenge map