Full list of all 637 The Binding of Isaac: Rebirth achievements. It takes around 200 hours to unlock all of the achievements in the base game on Windows.
The base game contains 242 achievements, and there are 4 DLC packs containing 395 achievements.
Unlocked a new item.
Unlocked a new character.
New mode unlocked!
Unlocked new enemies!
Alt stage to the basement.
Alt stage to the caves.
Alt stage to the depths.
Alt stage to the womb.
Unlocked new bosses!
Unlocked even more bosses!
Built him out of meat cubes.
OMG!
111% now stop playing!
Donated 600 pennies to the shop.
Beat depths without taking damage.
Unlocked a new co-player baby.
Beat Chest or Dark Room without taking damage.
Unlocked Challenge #11.
You became Lord of the Flies.
New boss in the womb!
Unlocked Challenge #19.
Donated 200 pennies to the shop.
You are the best!!
Unlocked Challenge #8.
New boss in the caves!
Isaac now holds the D6!
New boss in the basement!
They are waiting.
New boss in the depths!
Unlocked a new boss!
Your future's past waits.
Unlocked Challenge #4.
Unlocked Challenge #7.
Donated 100 pennies to the shop.
Unlocked Challenge #9.
Unlocked another miniboss!
The game just got harder!
Beat womb without taking damage.
Unlocked Challenge #6.
Beat caves without taking damage.
Destroy 100 rocks.
Donated 20 pennies to the shop.
Unlocked Challenge #5.
Unlocked Challenge #10.
Beat basement without taking damage.
Chapter 4 - The Womb unlocked.
The horsemen are loose.
Unlocked Challenge #20.
Nerd x 1000000
Unlocked a new starting item.
Unlocked a secret.
Greed just got harder!
Unlocked a new item
Unlocked a hidden chapter.
Unlocked Challenge #21.
Unlocked Challenge #22.
Unlocked Challenge #23.
Unlocked Challenge #24.
Unlocked Challenge #25.
Unlocked Challenge #26.
Unlocked Challenge #27.
Unlocked Challenge #28.
Unlocked Challenge #29.
Unlocked Challenge #30.
Unlocked...
Unlocked super special rocks.
Unlocked the power of RERUN.
Unlocked a new area.
Unlocked a new challenge.
They will charge you up... for a small fee.
Complete the final chapter with Apollyon.
Kill 10 Battery Bums.
Beat everything in Hard mode with Bethany.
Complete the Corpse with Bethany.
Complete the final chapter with Bethany.
Complete the Corpse with Lilith.
Complete the Corpse with Eve.
Complete the Corpse with Keeper.
Complete the final chapter with Lilith.
Complete the Corpse with the Lost.
Complete the final chapter with Samson.
Beat Greed mode with Jacob and Esau.
Beat Greedier mode with Jacob and Esau.
Complete the Corpse with Apollyon.
Complete the final chapter with Jacob and Esau.
Complete Boss Rush with Jacob and Esau.
Complete the Corpse with Lazarus.
Complete the Corpse with Samson.
Complete Boss Rush with Bethany.
Complete the final chapter with the Lost.
Complete the final chapter with Magdalene.
Complete the Corpse with Magdalene.
Complete the final chapter with Eve.
Beat the Void with Bethany.
Complete the Dark Room with Bethany.
Complete Sheol with Bethany.
Complete ??? with Bethany.
Complete the Chest with Jacob and Esau.
Complete the Cathedral with Jacob and Esau.
Beat the game in Hard mode with Jacob and Esau.
Complete the final chapter with Keeper.
Complete the Corpse with ???.
Get that song out of her head.
Complete the final chapter with Eden.
Complete the final chapter with Cain.
Complete the final chapter with ???.
Beat Greedier mode with Bethany.
Complete the Corpse with Azazel.
Complete the Corpse with Cain.
Complete the final chapter with Judas.
Complete the Corpse with Eden.
Complete the final chapter with Lazarus.
Complete the Corpse with Judas.
Kill Hornfel before he escapes!
Defeat all bosses in Downpour.
Defeat all bosses in the Mines.
Complete the final chapter with Azazel.
Complete the final chapter with Isaac.
The other side is calling...
Defeat Baby Plum 10 times.
You are just like your father...
Where could it lead to?
Complete the Corpse with Isaac.
Defeat all bosses in the Mausoleum.
Enter the Corpse...
Obtain 99 pennies. Then spend every single one of them.
Kids shouldn't believe in fortunes...
Make a new friend!
Beat Greed mode with Bethany.
Defeat Mega Satan with Bethany.
Complete the Chest with Bethany.
Complete the Cathedral with Bethany.
Beat the game in Hard mode with Bethany.
Spend 40+ pennies in a single shop.
Beat Hard mode as Lazarus without losing a life
Complete ??? 3 times.
Complete Sheol with Jacob and Esau.
Complete the Dark Room with Jacob and Esau.
Complete ??? with Jacob and Esau.
Complete the Void with Jacob and Esau.
Beat everything in Hard mode with Jacob and Esau.
Defeat Mega Satan with Jacob and Esau.
Complete the Corpse with the Forgotten.
Complete the final chapter with the Forgotten.
Complete the Corpse with Jacob and Esau.
Beat everything in Hard Mode as every character.