Full list of all 637 The Binding of Isaac: Rebirth achievements. It takes around 200 hours to unlock all of the achievements in the base game on Windows.
The base game contains 242 achievements, and there are 3 DLC packs containing 395 achievements.
Unlocked a new item.
Unlocked a new character.
New mode unlocked!
Alt stage to the basement.
Alt stage to the caves.
Alt stage to the depths.
Alt stage to the womb.
Unlocked new bosses!
Unlocked even more bosses!
Unlocked new enemies!
OMG!
111% now stop playing!
Unlocked a new co-player baby.
Unlocked Challenge #11.
Built him out of meat cubes.
Beat depths without taking damage.
Unlocked Challenge #19.
Donated 600 pennies to the shop.
Unlocked a new boss!
New boss in the womb!
You are the best!!
Beat Chest or Dark Room without taking damage.
You became Lord of the Flies.
They are waiting.
Isaac now holds the D6!
Your future's past waits.
Unlocked Challenge #4.
Unlocked Challenge #7.
Unlocked Challenge #8.
Unlocked Challenge #9.
New boss in the caves!
Donated 200 pennies to the shop.
New boss in the depths!
New boss in the basement!
Beat womb without taking damage.
The game just got harder!
Unlocked another miniboss!
Donated 100 pennies to the shop.
Unlocked Challenge #6.
Beat caves without taking damage.
Unlocked Challenge #5.
Unlocked Challenge #10.
Donated 20 pennies to the shop.
Beat basement without taking damage.
Destroy 100 rocks.
The horsemen are loose.
Unlocked Challenge #20.
Chapter 4 - The Womb unlocked.
Unlocked...
Nerd x 1000000
Unlocked a new starting item.
Unlocked a secret.
Unlocked a new item
Greed just got harder!
Unlocked a hidden chapter.
Unlocked Challenge #21.
Unlocked Challenge #22.
Unlocked Challenge #23.
Unlocked Challenge #24.
Unlocked Challenge #25.
Unlocked Challenge #26.
Unlocked Challenge #27.
Unlocked Challenge #28.
Unlocked Challenge #29.
Unlocked Challenge #30.
Unlocked super special rocks.
Unlocked the power of RERUN.
Unlocked a new area.
Unlocked a new challenge.
Complete the Corpse with Lilith.
Complete the final chapter with the Forgotten.
Complete the final chapter with Keeper.
Complete the final chapter with Apollyon.
Complete the final chapter with the Lost.
Complete the final chapter with Eden.
Complete the final chapter with Lazarus.
Complete the final chapter with Azazel.
Complete the final chapter with Samson.
Complete the final chapter with Eve.
Complete the final chapter with ???.
Complete the final chapter with Judas.
Complete the final chapter with Magdalene.
Beat Greed mode with Jacob and Esau.
Beat Greedier mode with Jacob and Esau.
Beat everything in Hard mode with Bethany.
Beat the Void with Bethany.
Complete the final chapter with Isaac.
Complete the Chest with Jacob and Esau.
Complete the Cathedral with Jacob and Esau.
Kill 10 Battery Bums.
Complete the Corpse with Bethany.
Complete the final chapter with Bethany.
Get that song out of her head.
Complete the final chapter with Lilith.
Complete the final chapter with Cain.
Defeat Mega Satan with Jacob and Esau.
Complete the Dark Room with Jacob and Esau.
Complete Sheol with Jacob and Esau.
Complete Boss Rush with Jacob and Esau.
Complete the Corpse with Keeper.
Beat Greed mode with Bethany.
Beat Greedier mode with Bethany.
Beat the game in Hard mode with Jacob and Esau.
Complete the Corpse with the Forgotten.
Complete the Corpse with Apollyon.
Complete the Dark Room with Bethany.
Complete ??? with Bethany.
Complete the Corpse with the Lost.
Complete the Corpse with Eden.
Complete the Corpse with Azazel.
Complete the Corpse with Lazarus.
Complete Boss Rush with Bethany.
Complete Sheol with Bethany.
Complete the Corpse with Samson.
Complete the Corpse with Eve.
Complete the Corpse with ???.
Complete the Corpse with Magdalene.
Complete the Corpse with Judas.
Complete the Corpse with Cain.
The other side is calling...
You are just like your father...
Complete the Corpse with Isaac.
Where could it lead to?
Defeat Baby Plum 10 times.
Enter the Corpse...
Defeat all bosses in the Mausoleum.
Spend 40+ pennies in a single shop.
Defeat Mega Satan with Bethany.
Beat the game in Hard mode with Bethany.
Complete the Chest with Bethany.
Complete the Cathedral with Bethany.
Beat Hard mode as Lazarus without losing a life
Obtain 99 pennies. Then spend every single one of them.
Defeat all bosses in Downpour.
Defeat all bosses in the Mines.
Kill Hornfel before he escapes!
Kids shouldn't believe in fortunes...
Complete ??? 3 times.
Make a new friend!
Complete ??? with Jacob and Esau.
Complete the Void with Jacob and Esau.
Beat everything in Hard mode with Jacob and Esau.
Complete the Corpse with Jacob and Esau.
Complete the final chapter with Jacob and Esau.
They will charge you up... for a small fee.
Beat everything in Hard Mode as every character.