Full list of all 637 The Binding of Isaac: Rebirth achievements. It takes around 200 hours to unlock all of the achievements in the base game on Windows.
The base game contains 242 achievements, and there are 3 DLC packs containing 395 achievements.
Unlocked a new item.
New mode unlocked!
Alt stage to the basement.
Alt stage to the caves.
Alt stage to the depths.
Alt stage to the womb.
Unlocked new bosses!
Unlocked even more bosses!
Unlocked new enemies!
Unlocked a new character.
New boss in the basement!
New boss in the caves!
Beat caves without taking damage.
Beat womb without taking damage.
You are the best!!
Unlocked a new boss!
New boss in the womb!
OMG!
Beat Chest or Dark Room without taking damage.
111% now stop playing!
Built him out of meat cubes.
Donated 200 pennies to the shop.
Donated 600 pennies to the shop.
Unlocked Challenge #11.
Unlocked Challenge #19.
Unlocked a new co-player baby.
You became Lord of the Flies.
They are waiting.
Isaac now holds the D6!
Unlocked Challenge #6.
Your future's past waits.
Unlocked Challenge #4.
Unlocked Challenge #7.
Beat depths without taking damage.
New boss in the depths!
Unlocked Challenge #9.
Donated 100 pennies to the shop.
The game just got harder!
Beat basement without taking damage.
Unlocked another miniboss!
Unlocked Challenge #8.
Unlocked Challenge #5.
Unlocked Challenge #10.
Chapter 4 - The Womb unlocked.
The horsemen are loose.
Unlocked Challenge #20.
Destroy 100 rocks.
Donated 20 pennies to the shop.
Nerd x 1000000
Unlocked...
Unlocked a new item
Unlocked a new starting item.
Unlocked a secret.
Greed just got harder!
Unlocked a hidden chapter.
Unlocked Challenge #21.
Unlocked Challenge #22.
Unlocked Challenge #23.
Unlocked Challenge #24.
Unlocked Challenge #25.
Unlocked Challenge #26.
Unlocked Challenge #27.
Unlocked Challenge #28.
Unlocked Challenge #29.
Unlocked Challenge #30.
Unlocked the power of RERUN.
Unlocked super special rocks.
Unlocked a new area.
Unlocked a new challenge.
Complete the final chapter with Apollyon.
Beat everything in Hard Mode as every character.
Complete the final chapter with Judas.
Complete the final chapter with Magdalene.
Complete the final chapter with the Forgotten.
Complete the Corpse with Samson.
Complete the Corpse with Eden.
Complete the Corpse with Eve.
Complete the Corpse with Lazarus.
Complete the Corpse with Apollyon.
Complete the Corpse with Judas.
Complete the Corpse with Lilith.
Complete the Corpse with the Forgotten.
Beat Greed mode with Bethany.
Beat Greedier mode with Bethany.
Beat everything in Hard mode with Bethany.
Beat the Void with Bethany.
Complete the Corpse with Magdalene.
Complete the Corpse with Cain.
Defeat Mega Satan with Bethany.
Complete the Corpse with Bethany.
Complete the final chapter with Eden.
They will charge you up... for a small fee.
Complete the Corpse with ???.
Complete the final chapter with Samson.
Complete the final chapter with Bethany.
Complete the Corpse with Isaac.
Complete the final chapter with Cain.
Complete the Corpse with Keeper.
Beat Greed mode with Jacob and Esau.
Beat Greedier mode with Jacob and Esau.
Beat everything in Hard mode with Jacob and Esau.
Complete the Void with Jacob and Esau.
Complete ??? with Jacob and Esau.
Complete the Corpse with Jacob and Esau.
Complete the final chapter with Keeper.
Complete Boss Rush with Jacob and Esau.
Complete the final chapter with Eve.
Complete the final chapter with Lilith.
Complete the final chapter with ???.
Complete the Dark Room with Bethany.
Complete Sheol with Bethany.
Complete the final chapter with Jacob and Esau.
Defeat Mega Satan with Jacob and Esau.
Complete the Dark Room with Jacob and Esau.
Complete Sheol with Jacob and Esau.
Complete the Chest with Bethany.
Complete the Cathedral with Bethany.
Complete ??? with Bethany.
Beat the game in Hard mode with Bethany.
Complete the Corpse with the Lost.
Complete the final chapter with the Lost.
Complete the final chapter with Isaac.
Complete Boss Rush with Bethany.
Obtain 99 pennies. Then spend every single one of them.
Beat Hard mode as Lazarus without losing a life
Kill 10 Battery Bums.
Complete the Chest with Jacob and Esau.
Complete the Cathedral with Jacob and Esau.
Beat the game in Hard mode with Jacob and Esau.
Get that song out of her head.
Defeat all bosses in the Mausoleum.
Defeat all bosses in the Mines.
Kill Hornfel before he escapes!
Kids shouldn't believe in fortunes...
Make a new friend!
Complete the final chapter with Lazarus.
Defeat Baby Plum 10 times.
Complete the final chapter with Azazel.
The other side is calling...
Spend 40+ pennies in a single shop.
You are just like your father...
Complete the Corpse with Azazel.
Where could it lead to?
Enter the Corpse...
Defeat all bosses in Downpour.
Complete ??? 3 times.