Full list of all 637 The Binding of Isaac: Rebirth achievements. It takes around 200 hours to unlock all of the achievements in the base game on Windows.
The base game contains 242 achievements, and there are 4 DLC packs containing 395 achievements.
Unlocked a new item.
Unlocked a new character.
New mode unlocked!
Alt stage to the basement.
Alt stage to the caves.
Alt stage to the depths.
Alt stage to the womb.
Unlocked new bosses!
Unlocked even more bosses!
Unlocked new enemies!
OMG!
111% now stop playing!
Built him out of meat cubes.
Beat Chest or Dark Room without taking damage.
Unlocked a new co-player baby.
Donated 600 pennies to the shop.
Unlocked Challenge #11.
New boss in the womb!
You are the best!!
Unlocked Challenge #19.
Beat womb without taking damage.
Unlocked a new boss!
You became Lord of the Flies.
New boss in the basement!
New boss in the caves!
They are waiting.
Isaac now holds the D6!
New boss in the depths!
Donated 200 pennies to the shop.
Your future's past waits.
Unlocked Challenge #4.
Unlocked Challenge #7.
Unlocked Challenge #9.
Donated 100 pennies to the shop.
Unlocked another miniboss!
The game just got harder!
Beat depths without taking damage.
Beat caves without taking damage.
Unlocked Challenge #6.
Unlocked Challenge #5.
Unlocked Challenge #10.
Destroy 100 rocks.
Unlocked Challenge #8.
Donated 20 pennies to the shop.
The horsemen are loose.
Unlocked Challenge #20.
Chapter 4 - The Womb unlocked.
Beat basement without taking damage.
Nerd x 1000000
Unlocked...
Unlocked a new item
Unlocked a new starting item.
Unlocked a secret.
Greed just got harder!
Unlocked a hidden chapter.
Unlocked Challenge #23.
Unlocked Challenge #24.
Unlocked Challenge #26.
Unlocked Challenge #27.
Unlocked Challenge #21.
Unlocked Challenge #22.
Unlocked Challenge #25.
Unlocked Challenge #28.
Unlocked Challenge #29.
Unlocked Challenge #30.
Unlocked super special rocks.
Unlocked the power of RERUN.
Unlocked a new area.
Unlocked a new challenge.
Complete the final chapter with Keeper.
Complete the Corpse with Keeper.
They will charge you up... for a small fee.
Complete the Corpse with Eve.
Complete the final chapter with Apollyon.
Complete the Corpse with the Lost.
Complete the final chapter with the Lost.
Complete the Corpse with Magdalene.
Kill 10 Battery Bums.
Complete the Corpse with the Forgotten.
Complete Sheol with Jacob and Esau.
Complete the Chest with Jacob and Esau.
Complete Boss Rush with Jacob and Esau.
Beat the Void with Bethany.
Complete the final chapter with Bethany.
Complete the Corpse with Cain.
Complete the Corpse with Apollyon.
Make a new friend!
Complete the Corpse with Bethany.
Complete the Corpse with Samson.
Complete the Corpse with Lazarus.
Get that song out of her head.
Complete the final chapter with Isaac.
Complete the final chapter with Eve.
Complete the final chapter with Magdalene.
Complete the final chapter with Samson.
Complete the final chapter with Cain.
Complete the final chapter with Judas.
Complete the final chapter with Lilith.
Complete the Corpse with Eden.
Complete the final chapter with the Forgotten.
Complete the final chapter with Eden.
Complete the final chapter with Azazel.
The other side is calling...
Complete the Corpse with Isaac.
Complete the Corpse with Judas.
Complete the Cathedral with Jacob and Esau.
Kids shouldn't believe in fortunes...
Beat the game in Hard mode with Bethany.
Defeat Baby Plum 10 times.
Defeat Mega Satan with Bethany.
Complete the Dark Room with Bethany.
Complete Sheol with Bethany.
Complete the Chest with Bethany.
Complete the Cathedral with Bethany.
Complete ??? with Bethany.
Complete Boss Rush with Bethany.
Defeat all bosses in the Mausoleum.
Beat Greed mode with Bethany.
Obtain 99 pennies. Then spend every single one of them.
Defeat all bosses in Downpour.
Beat Hard mode as Lazarus without losing a life
You are just like your father...
Where could it lead to?
Complete the Corpse with Azazel.
Defeat all bosses in the Mines.
Enter the Corpse...
Kill Hornfel before he escapes!
Spend 40+ pennies in a single shop.
Complete ??? 3 times.
Beat Greedier mode with Bethany.
Beat everything in Hard mode with Bethany.
Beat the game in Hard mode with Jacob and Esau.
Complete the Dark Room with Jacob and Esau.
Beat Greed mode with Jacob and Esau.
Complete ??? with Jacob and Esau.
Beat Greedier mode with Jacob and Esau.
Complete the Void with Jacob and Esau.
Beat everything in Hard mode with Jacob and Esau.
Defeat Mega Satan with Jacob and Esau.
Complete the Corpse with ???.
Complete the final chapter with ???.
Complete the final chapter with Lazarus.
Complete the Corpse with Lilith.
Complete the Corpse with Jacob and Esau.
Complete the final chapter with Jacob and Esau.
Beat everything in Hard Mode as every character.