Full list of all 637 The Binding of Isaac: Rebirth achievements. It takes around 200 hours to unlock all of the achievements in the base game on Windows.
The base game contains 242 achievements, and there are 4 DLC packs containing 395 achievements.
Unlocked a new co-player baby.
Unlocked a new item.
New mode unlocked!
Unlocked a new character.
Donated 600 pennies to the shop.
Unlocked even more bosses!
Built him out of meat cubes.
Unlocked Challenge #11.
Unlocked new enemies!
Alt stage to the basement.
Alt stage to the caves.
Alt stage to the depths.
Alt stage to the womb.
Unlocked new bosses!
New boss in the womb!
Beat Chest or Dark Room without taking damage.
Beat womb without taking damage.
You are the best!!
Unlocked Challenge #19.
They are waiting.
Isaac now holds the D6!
Donated 200 pennies to the shop.
Unlocked a new boss!
New boss in the basement!
New boss in the caves!
Unlocked Challenge #4.
Unlocked Challenge #7.
Your future's past waits.
Donated 100 pennies to the shop.
New boss in the depths!
Unlocked another miniboss!
Unlocked Challenge #9.
You became Lord of the Flies.
The game just got harder!
Donated 20 pennies to the shop.
Unlocked Challenge #6.
Beat depths without taking damage.
Beat caves without taking damage.
Unlocked Challenge #8.
Unlocked Challenge #5.
Unlocked Challenge #10.
Chapter 4 - The Womb unlocked.
The horsemen are loose.
Unlocked Challenge #20.
Destroy 100 rocks.
Beat basement without taking damage.
OMG!
111% now stop playing!
Unlocked...
Unlocked a new item
Unlocked a new starting item.
Unlocked a secret.
Nerd x 1000000
Greed just got harder!
Unlocked a hidden chapter.
Unlocked Challenge #21.
Unlocked Challenge #22.
Unlocked Challenge #23.
Unlocked Challenge #24.
Unlocked Challenge #25.
Unlocked Challenge #26.
Unlocked Challenge #27.
Unlocked Challenge #28.
Unlocked Challenge #29.
Unlocked Challenge #30.
Unlocked super special rocks.
Unlocked a new area.
Unlocked a new challenge.
Unlocked the power of RERUN.
Complete the Corpse with Magdalene.
Complete the Corpse with Eden.
Complete the Corpse with Lilith.
Beat Greedier mode with Bethany.
Complete the Corpse with Judas.
Complete the final chapter with Judas.
Complete the final chapter with the Lost.
Complete the Corpse with the Lost.
Complete the Corpse with Cain.
Complete the Corpse with Keeper.
Complete the final chapter with Apollyon.
Complete the final chapter with Eden.
Beat the Void with Bethany.
Beat Greed mode with Jacob and Esau.
Beat Greedier mode with Jacob and Esau.
Complete the final chapter with Jacob and Esau.
Complete the final chapter with Keeper.
Obtain 99 pennies. Then spend every single one of them.
Complete the final chapter with ???.
Complete the final chapter with Samson.
Complete the final chapter with Eve.
Complete the final chapter with Lazarus.
Complete the final chapter with Magdalene.
Complete the Corpse with Isaac.
Complete the final chapter with Lilith.
Kill 10 Battery Bums.
Complete the Dark Room with Jacob and Esau.
Complete Sheol with Jacob and Esau.
Complete the Void with Jacob and Esau.
Defeat Mega Satan with Jacob and Esau.
Complete the Chest with Jacob and Esau.
Complete the Cathedral with Jacob and Esau.
Complete Boss Rush with Jacob and Esau.
Complete the Corpse with Bethany.
Complete the final chapter with Cain.
Complete the final chapter with Isaac.
Kids shouldn't believe in fortunes...
Complete the final chapter with Azazel.
Defeat Baby Plum 10 times.
Complete the Corpse with the Forgotten.
Beat Greed mode with Bethany.
Defeat Mega Satan with Bethany.
Complete the Dark Room with Bethany.
Complete Sheol with Bethany.
Complete ??? with Bethany.
Complete the Chest with Bethany.
Complete the Cathedral with Bethany.
Spend 40+ pennies in a single shop.
Complete Boss Rush with Bethany.
Complete the final chapter with the Forgotten.
The other side is calling...
You are just like your father...
Complete the Corpse with Azazel.
Where could it lead to?
Kill Hornfel before he escapes!
Beat Hard mode as Lazarus without losing a life
Enter the Corpse...
Defeat all bosses in the Mausoleum.
Get that song out of her head.
Defeat all bosses in the Mines.
Defeat all bosses in Downpour.
Complete ??? 3 times.
Make a new friend!
Beat the game in Hard mode with Bethany.
Beat everything in Hard mode with Bethany.
Beat the game in Hard mode with Jacob and Esau.
Complete ??? with Jacob and Esau.
Beat everything in Hard mode with Jacob and Esau.
Complete the Corpse with ???.
Complete the Corpse with Eve.
Complete the Corpse with Samson.
Complete the Corpse with Lazarus.
Complete the Corpse with Apollyon.
Complete the final chapter with Bethany.
Complete the Corpse with Jacob and Esau.
They will charge you up... for a small fee.
Beat everything in Hard Mode as every character.