Full list of all 637 The Binding of Isaac: Rebirth achievements. It takes around 200 hours to unlock all of the achievements in the base game on Windows.
The base game contains 242 achievements, and there are 4 DLC packs containing 395 achievements.
Unlocked a new item.
New mode unlocked!
Beat womb without taking damage.
Beat depths without taking damage.
111% now stop playing!
Unlocked Challenge #11.
Unlocked a new co-player baby.
Built him out of meat cubes.
Unlocked a new character.
Unlocked even more bosses!
Alt stage to the basement.
Alt stage to the caves.
Alt stage to the depths.
Alt stage to the womb.
Unlocked new bosses!
Unlocked new enemies!
Donated 600 pennies to the shop.
Beat Chest or Dark Room without taking damage.
Isaac now holds the D6!
New boss in the womb!
Unlocked Challenge #19.
You are the best!!
Beat caves without taking damage.
They are waiting.
Donated 200 pennies to the shop.
Unlocked a new boss!
Your future's past waits.
Unlocked Challenge #4.
Unlocked Challenge #7.
Unlocked Challenge #9.
New boss in the depths!
New boss in the caves!
The game just got harder!
Unlocked Challenge #8.
Donated 100 pennies to the shop.
Unlocked another miniboss!
Beat basement without taking damage.
Unlocked Challenge #6.
New boss in the basement!
You became Lord of the Flies.
Unlocked Challenge #5.
Unlocked Challenge #10.
The horsemen are loose.
Unlocked Challenge #20.
Chapter 4 - The Womb unlocked.
Donated 20 pennies to the shop.
Destroy 100 rocks.
OMG!
Unlocked a new item
Unlocked a new starting item.
Unlocked...
Unlocked a secret.
Nerd x 1000000
Unlocked Challenge #24.
Greed just got harder!
Unlocked Challenge #27.
Unlocked Challenge #26.
Unlocked a hidden chapter.
Unlocked Challenge #21.
Unlocked Challenge #22.
Unlocked Challenge #23.
Unlocked Challenge #25.
Unlocked Challenge #28.
Unlocked Challenge #29.
Unlocked Challenge #30.
Unlocked super special rocks.
Unlocked the power of RERUN.
Unlocked a new area.
Unlocked a new challenge.
Complete the final chapter with Keeper.
Beat everything in Hard Mode as every character.
Beat everything in Hard mode with Bethany.
Complete the final chapter with Bethany.
Complete ??? with Jacob and Esau.
Beat everything in Hard mode with Jacob and Esau.
Complete the final chapter with ???.
Complete the Corpse with ???.
Beat Greed mode with Jacob and Esau.
Beat Greedier mode with Jacob and Esau.
Complete the Corpse with the Lost.
Beat Greedier mode with Bethany.
Complete the final chapter with Jacob and Esau.
Beat the Void with Bethany.
Complete ??? with Bethany.
Complete Boss Rush with Bethany.
Complete the Void with Jacob and Esau.
Complete the Corpse with Jacob and Esau.
Complete the Corpse with Keeper.
Complete the Corpse with Lazarus.
Complete the Corpse with Apollyon.
Defeat Mega Satan with Jacob and Esau.
Complete the Dark Room with Jacob and Esau.
Complete the Corpse with Eve.
Complete the final chapter with Apollyon.
Complete the Corpse with the Forgotten.
Complete the Corpse with Samson.
Complete Sheol with Jacob and Esau.
Complete the Corpse with Lilith.
Complete the Corpse with Magdalene.
Kill 10 Battery Bums.
Complete the final chapter with the Lost.
Complete the Corpse with Cain.
They will charge you up... for a small fee.
Kids shouldn't believe in fortunes...
Complete Boss Rush with Jacob and Esau.
Beat Greed mode with Bethany.
Complete the Corpse with Isaac.
Complete the Chest with Jacob and Esau.
Complete the Cathedral with Jacob and Esau.
Beat the game in Hard mode with Jacob and Esau.
Complete the final chapter with Samson.
Complete the Corpse with Judas.
Complete the final chapter with Lilith.
Make a new friend!
Complete the final chapter with Eve.
Complete the final chapter with Cain.
Complete the Corpse with Bethany.
Complete the final chapter with Eden.
Complete the Dark Room with Bethany.
Complete Sheol with Bethany.
Defeat Baby Plum 10 times.
Complete the final chapter with Magdalene.
Complete the final chapter with the Forgotten.
Complete the Corpse with Eden.
Get that song out of her head.
Defeat all bosses in the Mausoleum.
Obtain 99 pennies. Then spend every single one of them.
Complete the final chapter with Lazarus.
Complete the final chapter with Judas.
Spend 40+ pennies in a single shop.
Defeat Mega Satan with Bethany.
Complete the Chest with Bethany.
Complete the Cathedral with Bethany.
Beat the game in Hard mode with Bethany.
Complete the final chapter with Isaac.
Complete the final chapter with Azazel.
The other side is calling...
You are just like your father...
Where could it lead to?
Complete the Corpse with Azazel.
Enter the Corpse...
Defeat all bosses in the Mines.
Kill Hornfel before he escapes!
Beat Hard mode as Lazarus without losing a life
Defeat all bosses in Downpour.
Complete ??? 3 times.