Full list of all 637 The Binding of Isaac: Rebirth achievements. It takes around 200 hours to unlock all of the achievements in the base game on Windows.
The base game contains 242 achievements, and there are 3 DLC packs containing 395 achievements.
Unlocked a new item.
Unlocked a new character.
New mode unlocked!
Alt stage to the basement.
Alt stage to the caves.
Alt stage to the depths.
Alt stage to the womb.
Unlocked new bosses!
Unlocked even more bosses!
Unlocked new enemies!
111% now stop playing!
OMG!
Built him out of meat cubes.
Unlocked a new co-player baby.
Donated 600 pennies to the shop.
Unlocked Challenge #11.
Unlocked Challenge #19.
Beat Chest or Dark Room without taking damage.
Donated 200 pennies to the shop.
Isaac now holds the D6!
New boss in the womb!
Unlocked a new boss!
New boss in the basement!
You are the best!!
New boss in the caves!
They are waiting.
Beat womb without taking damage.
New boss in the depths!
Unlocked Challenge #4.
Unlocked Challenge #7.
Your future's past waits.
Unlocked Challenge #9.
Beat depths without taking damage.
You became Lord of the Flies.
Donated 100 pennies to the shop.
Unlocked another miniboss!
Beat caves without taking damage.
Unlocked Challenge #8.
The game just got harder!
Unlocked Challenge #6.
The horsemen are loose.
Unlocked Challenge #20.
Chapter 4 - The Womb unlocked.
Destroy 100 rocks.
Unlocked Challenge #5.
Unlocked Challenge #10.
Donated 20 pennies to the shop.
Beat basement without taking damage.
Nerd x 1000000
Unlocked...
Unlocked a new starting item.
Unlocked a new item
Unlocked a secret.
Greed just got harder!
Unlocked a hidden chapter.
Unlocked Challenge #21.
Unlocked Challenge #22.
Unlocked Challenge #23.
Unlocked Challenge #24.
Unlocked Challenge #25.
Unlocked Challenge #26.
Unlocked Challenge #27.
Unlocked Challenge #28.
Unlocked Challenge #29.
Unlocked Challenge #30.
Unlocked super special rocks.
Unlocked the power of RERUN.
Unlocked a new area.
Unlocked a new challenge.
Beat everything in Hard mode with Jacob and Esau.
Beat everything in Hard Mode as every character.
Complete the final chapter with Jacob and Esau.
Complete the Void with Jacob and Esau.
Complete the Corpse with Jacob and Esau.
Defeat Mega Satan with Jacob and Esau.
Complete the Dark Room with Jacob and Esau.
Complete Sheol with Jacob and Esau.
Complete ??? with Jacob and Esau.
Complete Boss Rush with Jacob and Esau.
Complete the Corpse with the Forgotten.
Complete the final chapter with the Forgotten.
Complete the final chapter with Apollyon.
Complete the Corpse with Apollyon.
Complete the final chapter with Keeper.
Complete the Corpse with Keeper.
Complete the final chapter with Lilith.
Complete the Corpse with Lilith.
Complete the final chapter with the Lost.
Complete the Corpse with the Lost.
Complete the final chapter with Eden.
Complete the Corpse with Eden.
Kill 10 Battery Bums.
Beat Greedier mode with Jacob and Esau.
Beat Greed mode with Jacob and Esau.
Complete the Corpse with Lazarus.
Complete the final chapter with Lazarus.
Beat everything in Hard mode with Bethany.
Beat the Void with Bethany.
Complete the Corpse with Bethany.
Complete the final chapter with Bethany.
Beat Greed mode with Bethany.
Beat Greedier mode with Bethany.
Complete the final chapter with Azazel.
Complete the Chest with Jacob and Esau.
Complete the Cathedral with Jacob and Esau.
Beat the game in Hard mode with Jacob and Esau.
Complete the Dark Room with Bethany.
Complete Sheol with Bethany.
Defeat Mega Satan with Bethany.
Complete the Chest with Bethany.
They will charge you up... for a small fee.
Complete ??? with Bethany.
Complete Boss Rush with Bethany.
Complete the Cathedral with Bethany.
Beat the game in Hard mode with Bethany.
Complete the Corpse with Azazel.
Complete the final chapter with Samson.
Complete the Corpse with Samson.
Complete the final chapter with Eve.
Complete the Corpse with Eve.
Complete the Corpse with ???.
Defeat Baby Plum 10 times.
Complete the final chapter with ???.
Complete the final chapter with Judas.
Complete the Corpse with Judas.
Complete the Corpse with Cain.
Complete the final chapter with Cain.
Kids shouldn't believe in fortunes...
Obtain 99 pennies. Then spend every single one of them.
Make a new friend!
Complete the final chapter with Magdalene.
Complete the Corpse with Magdalene.
Complete the final chapter with Isaac.
The other side is calling...
You are just like your father...
Complete the Corpse with Isaac.
Where could it lead to?
Defeat all bosses in the Mausoleum.
Spend 40+ pennies in a single shop.
Defeat all bosses in the Mines.
Enter the Corpse...
Get that song out of her head.
Kill Hornfel before he escapes!
Beat Hard mode as Lazarus without losing a life
Defeat all bosses in Downpour.
Complete ??? 3 times.