Full list of all 637 The Binding of Isaac: Rebirth achievements. It takes around 200 hours to unlock all of the achievements in the base game on Windows.
The base game contains 242 achievements, and there are 4 DLC packs containing 395 achievements.
Unlocked a new item.
Unlocked a new character.
New mode unlocked!
Alt stage to the basement.
Alt stage to the caves.
Alt stage to the depths.
Alt stage to the womb.
Unlocked new bosses!
Unlocked even more bosses!
Unlocked new enemies!
OMG!
Unlocked a new co-player baby.
Built him out of meat cubes.
Beat caves without taking damage.
Unlocked Challenge #11.
Beat Chest or Dark Room without taking damage.
New boss in the womb!
Unlocked Challenge #19.
Unlocked Challenge #8.
You are the best!!
They are waiting.
Donated 600 pennies to the shop.
Isaac now holds the D6!
Unlocked a new boss!
Your future's past waits.
Unlocked Challenge #4.
Unlocked Challenge #7.
Beat womb without taking damage.
New boss in the caves!
New boss in the basement!
Unlocked Challenge #9.
New boss in the depths!
Donated 200 pennies to the shop.
The game just got harder!
Beat depths without taking damage.
Unlocked Challenge #6.
Unlocked another miniboss!
You became Lord of the Flies.
Donated 100 pennies to the shop.
Beat basement without taking damage.
Donated 20 pennies to the shop.
Chapter 4 - The Womb unlocked.
The horsemen are loose.
Unlocked Challenge #20.
Destroy 100 rocks.
Unlocked Challenge #5.
Unlocked Challenge #10.
111% now stop playing!
Nerd x 1000000
Unlocked a new starting item.
Unlocked a secret.
Greed just got harder!
Unlocked a hidden chapter.
Unlocked Challenge #21.
Unlocked Challenge #22.
Unlocked Challenge #23.
Unlocked Challenge #24.
Unlocked Challenge #25.
Unlocked Challenge #26.
Unlocked Challenge #27.
Unlocked Challenge #28.
Unlocked Challenge #29.
Unlocked Challenge #30.
Unlocked a new item
Unlocked...
Unlocked super special rocks.
Unlocked the power of RERUN.
Unlocked a new area.
Unlocked a new challenge.
Complete the Corpse with Jacob and Esau.
Defeat Mega Satan with Jacob and Esau.
Complete the Dark Room with Jacob and Esau.
Complete Sheol with Jacob and Esau.
Make a new friend!
Kids shouldn't believe in fortunes...
Complete the final chapter with the Lost.
Complete the final chapter with Apollyon.
Complete the final chapter with the Forgotten.
Complete the final chapter with Bethany.
Complete the final chapter with Eden.
Complete the final chapter with Lazarus.
Complete the final chapter with Azazel.
Complete the final chapter with Samson.
Complete the final chapter with Eve.
Complete the final chapter with ???.
Defeat all bosses in the Mausoleum.
Complete the final chapter with Cain.
Complete the final chapter with Judas.
Complete the final chapter with Lilith.
Complete the final chapter with Magdalene.
Complete the Chest with Jacob and Esau.
Complete the Cathedral with Jacob and Esau.
Complete Boss Rush with Jacob and Esau.
Complete the Void with Jacob and Esau.
Complete ??? with Jacob and Esau.
Beat the game in Hard mode with Jacob and Esau.
Beat Greed mode with Jacob and Esau.
Beat Greedier mode with Jacob and Esau.
Defeat Baby Plum 10 times.
Complete the final chapter with Isaac.
The other side is calling...
Complete the Corpse with Isaac.
You are just like your father...
Complete the Corpse with Apollyon.
Where could it lead to?
Enter the Corpse...
Obtain 99 pennies. Then spend every single one of them.
Beat Greed mode with Bethany.
Beat Greedier mode with Bethany.
Spend 40+ pennies in a single shop.
Defeat all bosses in Downpour.
Complete the Chest with Bethany.
Complete the Cathedral with Bethany.
Beat the game in Hard mode with Bethany.
Defeat all bosses in the Mines.
Kill Hornfel before he escapes!
Complete ??? 3 times.
Beat Hard mode as Lazarus without losing a life
Get that song out of her head.
Complete Sheol with Bethany.
Complete the Dark Room with Bethany.
Complete Boss Rush with Bethany.
Complete ??? with Bethany.
Beat the Void with Bethany.
Beat everything in Hard mode with Bethany.
Defeat Mega Satan with Bethany.
Beat everything in Hard mode with Jacob and Esau.
Complete the Corpse with Magdalene.
Complete the Corpse with Cain.
Complete the Corpse with Judas.
Complete the Corpse with ???.
Complete the Corpse with Eve.
Complete the Corpse with Samson.
Complete the Corpse with Azazel.
Complete the Corpse with Lazarus.
Complete the Corpse with Eden.
Complete the Corpse with the Lost.
Complete the Corpse with Lilith.
Complete the Corpse with Keeper.
Complete the final chapter with Keeper.
Complete the Corpse with the Forgotten.
Complete the Corpse with Bethany.
Complete the final chapter with Jacob and Esau.
They will charge you up... for a small fee.
Kill 10 Battery Bums.
Beat everything in Hard Mode as every character.