Full list of all 637 The Binding of Isaac: Rebirth achievements. It takes around 200 hours to unlock all of the achievements in the base game on Windows.
The base game contains 242 achievements, and there are 3 DLC packs containing 395 achievements.
Unlocked a new item.
OMG!
111% now stop playing!
Unlocked Challenge #11.
Unlocked a new co-player baby.
New mode unlocked!
Built him out of meat cubes.
Donated 600 pennies to the shop.
Unlocked a new character.
Beat Chest or Dark Room without taking damage.
Alt stage to the basement.
Alt stage to the caves.
Alt stage to the depths.
Alt stage to the womb.
Unlocked new bosses!
Unlocked even more bosses!
Unlocked new enemies!
Unlocked Challenge #19.
Isaac now holds the D6!
Beat depths without taking damage.
New boss in the womb!
Donated 200 pennies to the shop.
Beat womb without taking damage.
You became Lord of the Flies.
You are the best!!
Unlocked Challenge #4.
They are waiting.
Your future's past waits.
Unlocked Challenge #7.
Unlocked a new boss!
New boss in the caves!
Unlocked Challenge #9.
New boss in the depths!
Donated 100 pennies to the shop.
New boss in the basement!
The game just got harder!
Beat caves without taking damage.
Unlocked Challenge #6.
Unlocked Challenge #5.
Unlocked Challenge #10.
Unlocked another miniboss!
Unlocked Challenge #8.
The horsemen are loose.
Unlocked Challenge #20.
Chapter 4 - The Womb unlocked.
Donated 20 pennies to the shop.
Destroy 100 rocks.
Beat basement without taking damage.
Unlocked...
Unlocked a new item
Unlocked a new starting item.
Nerd x 1000000
Unlocked a secret.
Greed just got harder!
Unlocked a hidden chapter.
Unlocked Challenge #21.
Unlocked Challenge #22.
Unlocked Challenge #23.
Unlocked Challenge #24.
Unlocked Challenge #25.
Unlocked Challenge #26.
Unlocked Challenge #27.
Unlocked Challenge #28.
Unlocked Challenge #29.
Unlocked Challenge #30.
Unlocked the power of RERUN.
Unlocked super special rocks.
Unlocked a new area.
Unlocked a new challenge.
Beat Greed mode with Jacob and Esau.
Beat Greedier mode with Jacob and Esau.
Beat everything in Hard mode with Jacob and Esau.
Beat everything in Hard Mode as every character.
Complete the Corpse with Jacob and Esau.
Complete ??? with Jacob and Esau.
Complete the final chapter with Jacob and Esau.
Complete the Dark Room with Jacob and Esau.
Complete Sheol with Jacob and Esau.
Complete the Void with Jacob and Esau.
Defeat Mega Satan with Jacob and Esau.
Complete the Chest with Jacob and Esau.
Complete the Cathedral with Jacob and Esau.
Complete the Corpse with Lilith.
Complete the Corpse with Apollyon.
Complete the Corpse with Lazarus.
Complete the Corpse with Samson.
Complete the Corpse with Eve.
Complete the Corpse with Magdalene.
Complete the Corpse with ???.
Beat Greedier mode with Bethany.
Beat everything in Hard mode with Bethany.
Complete the Corpse with Keeper.
Complete the Corpse with Cain.
Complete the final chapter with Cain.
Complete the final chapter with Lilith.
Complete the Corpse with Judas.
Complete the Corpse with the Forgotten.
Complete the final chapter with ???.
Complete the final chapter with Azazel.
Complete the final chapter with Eve.
Kill 10 Battery Bums.
Complete the Chest with Bethany.
Complete the Cathedral with Bethany.
Defeat Mega Satan with Bethany.
Complete the Dark Room with Bethany.
Complete Sheol with Bethany.
Beat the Void with Bethany.
Complete ??? with Bethany.
Complete Boss Rush with Bethany.
Complete the Corpse with Bethany.
Beat the game in Hard mode with Bethany.
Complete the Corpse with Eden.
Complete the final chapter with Keeper.
Complete the final chapter with the Lost.
Complete the Corpse with the Lost.
They will charge you up... for a small fee.
Complete the final chapter with the Forgotten.
Complete the final chapter with Judas.
Complete the final chapter with Apollyon.
Complete the final chapter with Magdalene.
Complete the Corpse with Isaac.
Complete the final chapter with Eden.
Complete the final chapter with Bethany.
Beat the game in Hard mode with Jacob and Esau.
Complete the final chapter with Samson.
Beat Greed mode with Bethany.
Obtain 99 pennies. Then spend every single one of them.
Get that song out of her head.
Complete the final chapter with Lazarus.
Complete the final chapter with Isaac.
Complete Boss Rush with Jacob and Esau.
The other side is calling...
You are just like your father...
Complete the Corpse with Azazel.
Where could it lead to?
Defeat all bosses in the Mausoleum.
Kill Hornfel before he escapes!
Defeat all bosses in the Mines.
Make a new friend!
Enter the Corpse...
Defeat all bosses in Downpour.
Complete ??? 3 times.
Defeat Baby Plum 10 times.
Spend 40+ pennies in a single shop.
Beat Hard mode as Lazarus without losing a life
Kids shouldn't believe in fortunes...