Full list of all 637 The Binding of Isaac: Rebirth achievements. It takes around 200 hours to unlock all of the achievements in the base game on Windows.
The base game contains 242 achievements, and there are 3 DLC packs containing 395 achievements.
Unlocked a new co-player baby.
Unlocked a new item.
Unlocked Challenge #11.
Beat depths without taking damage.
Donated 600 pennies to the shop.
New mode unlocked!
Unlocked a new character.
Unlocked even more bosses!
Alt stage to the basement.
Alt stage to the caves.
Alt stage to the depths.
Alt stage to the womb.
Unlocked new bosses!
Unlocked new enemies!
New boss in the womb!
You are the best!!
Unlocked another miniboss!
Beat Chest or Dark Room without taking damage.
Unlocked Challenge #19.
Beat womb without taking damage.
Beat caves without taking damage.
They are waiting.
You became Lord of the Flies.
Unlocked Challenge #8.
New boss in the caves!
Isaac now holds the D6!
New boss in the basement!
New boss in the depths!
Donated 200 pennies to the shop.
Your future's past waits.
Unlocked Challenge #4.
Unlocked Challenge #7.
Donated 100 pennies to the shop.
Unlocked Challenge #9.
Built him out of meat cubes.
Unlocked a new boss!
Donated 20 pennies to the shop.
The game just got harder!
Unlocked Challenge #6.
Beat basement without taking damage.
The horsemen are loose.
Unlocked Challenge #20.
Chapter 4 - The Womb unlocked.
Unlocked Challenge #5.
Unlocked Challenge #10.
Destroy 100 rocks.
OMG!
111% now stop playing!
Unlocked Challenge #24.
Unlocked a new starting item.
Nerd x 1000000
Unlocked a secret.
Greed just got harder!
Unlocked a hidden chapter.
Unlocked Challenge #21.
Unlocked Challenge #22.
Unlocked Challenge #23.
Unlocked Challenge #25.
Unlocked Challenge #26.
Unlocked Challenge #27.
Unlocked Challenge #28.
Unlocked Challenge #29.
Unlocked Challenge #30.
Unlocked a new item
Unlocked...
Unlocked the power of RERUN.
Unlocked a new area.
Unlocked a new challenge.
Unlocked super special rocks.
Complete the Corpse with the Forgotten.
Complete the Corpse with Jacob and Esau.
Beat the game in Hard mode with Jacob and Esau.
Complete the Corpse with Isaac.
Complete the Corpse with Apollyon.
Complete the Corpse with Cain.
Complete the Corpse with the Lost.
Complete the final chapter with Keeper.
Complete the final chapter with Lazarus.
Kill 10 Battery Bums.
Complete the final chapter with Eve.
Complete the final chapter with ???.
Complete the final chapter with Magdalene.
Complete the Chest with Jacob and Esau.
They will charge you up... for a small fee.
Complete the Cathedral with Jacob and Esau.
Complete Boss Rush with Jacob and Esau.
Complete the final chapter with Eden.
Complete the final chapter with Bethany.
Complete the final chapter with the Forgotten.
Complete the final chapter with Apollyon.
Complete the final chapter with the Lost.
Beat Greed mode with Jacob and Esau.
Defeat Baby Plum 10 times.
Complete the final chapter with Lilith.
Complete the Dark Room with Bethany.
Complete Sheol with Bethany.
Complete the final chapter with Cain.
Complete the final chapter with Isaac.
The other side is calling...
Make a new friend!
You are just like your father...
Where could it lead to?
Complete the Corpse with Azazel.
Get that song out of her head.
Defeat all bosses in the Mausoleum.
Defeat all bosses in the Mines.
Kill Hornfel before he escapes!
Defeat all bosses in Downpour.
Kids shouldn't believe in fortunes...
Obtain 99 pennies. Then spend every single one of them.
Spend 40+ pennies in a single shop.
Beat the Void with Bethany.
Defeat Mega Satan with Bethany.
Complete the Chest with Bethany.
Complete the Cathedral with Bethany.
Beat the game in Hard mode with Bethany.
Beat Hard mode as Lazarus without losing a life
Enter the Corpse...
Complete ??? 3 times.
Complete Boss Rush with Bethany.
Beat Greed mode with Bethany.
Complete ??? with Bethany.
Beat Greedier mode with Bethany.
Beat everything in Hard mode with Bethany.
Complete Sheol with Jacob and Esau.
Complete the Dark Room with Jacob and Esau.
Complete ??? with Jacob and Esau.
Beat Greedier mode with Jacob and Esau.
Complete the Void with Jacob and Esau.
Beat everything in Hard mode with Jacob and Esau.
Defeat Mega Satan with Jacob and Esau.
Complete the Corpse with Magdalene.
Complete the Corpse with Judas.
Complete the final chapter with Judas.
Complete the Corpse with ???.
Complete the Corpse with Eve.
Complete the Corpse with Samson.
Complete the final chapter with Samson.
Complete the final chapter with Azazel.
Complete the Corpse with Lazarus.
Complete the Corpse with Eden.
Complete the Corpse with Lilith.
Complete the Corpse with Keeper.
Complete the Corpse with Bethany.
Complete the final chapter with Jacob and Esau.
Beat everything in Hard Mode as every character.