Full list of all 637 The Binding of Isaac: Rebirth achievements. It takes around 200 hours to unlock all of the achievements in the base game on Windows.
The base game contains 242 achievements, and there are 4 DLC packs containing 395 achievements.
Unlocked a new co-player baby.
Unlocked a new item.
New mode unlocked!
Unlocked a new character.
Alt stage to the basement.
Alt stage to the caves.
Alt stage to the depths.
Alt stage to the womb.
Unlocked new bosses!
Unlocked even more bosses!
Unlocked new enemies!
Unlocked Challenge #11.
Beat womb without taking damage.
Built him out of meat cubes.
Beat Chest or Dark Room without taking damage.
New boss in the womb!
Isaac now holds the D6!
You are the best!!
Unlocked Challenge #19.
Beat depths without taking damage.
They are waiting.
Donated 600 pennies to the shop.
Unlocked Challenge #8.
Unlocked a new boss!
Your future's past waits.
Unlocked Challenge #4.
Unlocked Challenge #7.
New boss in the caves!
New boss in the basement!
Unlocked Challenge #9.
New boss in the depths!
Donated 200 pennies to the shop.
The game just got harder!
Unlocked Challenge #5.
Unlocked Challenge #10.
Unlocked Challenge #6.
Donated 100 pennies to the shop.
Beat basement without taking damage.
Beat caves without taking damage.
Unlocked another miniboss!
You became Lord of the Flies.
Chapter 4 - The Womb unlocked.
The horsemen are loose.
Unlocked Challenge #20.
Donated 20 pennies to the shop.
Destroy 100 rocks.
OMG!
111% now stop playing!
Unlocked a new starting item.
Unlocked a secret.
Nerd x 1000000
Greed just got harder!
Unlocked a hidden chapter.
Unlocked Challenge #21.
Unlocked Challenge #22.
Unlocked Challenge #23.
Unlocked Challenge #24.
Unlocked Challenge #25.
Unlocked Challenge #26.
Unlocked Challenge #27.
Unlocked Challenge #28.
Unlocked Challenge #29.
Unlocked Challenge #30.
Unlocked a new item
Unlocked...
Unlocked super special rocks.
Unlocked a new area.
Unlocked a new challenge.
Unlocked the power of RERUN.
Defeat Mega Satan with Bethany.
Complete the final chapter with Isaac.
Complete the Corpse with Isaac.
Complete the Chest with Jacob and Esau.
Complete the Cathedral with Jacob and Esau.
Beat the game in Hard mode with Jacob and Esau.
Complete Boss Rush with Jacob and Esau.
Complete Sheol with Jacob and Esau.
The other side is calling...
Beat Greedier mode with Jacob and Esau.
Beat Greed mode with Jacob and Esau.
You are just like your father...
Where could it lead to?
Complete the Corpse with ???.
Enter the Corpse...
Defeat all bosses in the Mines.
Beat Greed mode with Bethany.
Beat Greedier mode with Bethany.
Obtain 99 pennies. Then spend every single one of them.
Complete Sheol with Bethany.
Beat the game in Hard mode with Bethany.
Complete the Chest with Bethany.
Kids shouldn't believe in fortunes...
Complete the Cathedral with Bethany.
Complete Boss Rush with Bethany.
Complete ??? with Bethany.
Beat Hard mode as Lazarus without losing a life
Defeat Baby Plum 10 times.
Defeat all bosses in the Mausoleum.
Defeat all bosses in Downpour.
Get that song out of her head.
Spend 40+ pennies in a single shop.
Make a new friend!
Complete ??? 3 times.
Complete the Dark Room with Bethany.
Beat the Void with Bethany.
Beat everything in Hard mode with Bethany.
Complete the Dark Room with Jacob and Esau.
Complete ??? with Jacob and Esau.
Complete the Void with Jacob and Esau.
Beat everything in Hard mode with Jacob and Esau.
Defeat Mega Satan with Jacob and Esau.
Complete the Corpse with Magdalene.
Complete the final chapter with Magdalene.
Complete the Corpse with Cain.
Complete the final chapter with Cain.
Complete the Corpse with Judas.
Complete the final chapter with Judas.
Complete the final chapter with ???.
Complete the Corpse with Eve.
Complete the final chapter with Eve.
Complete the Corpse with Samson.
Complete the final chapter with Samson.
Complete the Corpse with Azazel.
Complete the final chapter with Azazel.
Complete the Corpse with Lazarus.
Complete the final chapter with Lazarus.
Complete the Corpse with Eden.
Complete the final chapter with Eden.
Complete the Corpse with the Lost.
Complete the final chapter with the Lost.
Complete the Corpse with Lilith.
Complete the final chapter with Lilith.
Complete the Corpse with Keeper.
Complete the final chapter with Keeper.
Complete the Corpse with Apollyon.
Complete the final chapter with Apollyon.
Complete the Corpse with the Forgotten.
Complete the final chapter with the Forgotten.
Complete the Corpse with Bethany.
Complete the final chapter with Bethany.
Complete the Corpse with Jacob and Esau.
Complete the final chapter with Jacob and Esau.
They will charge you up... for a small fee.
Kill 10 Battery Bums.
Kill Hornfel before he escapes!
Beat everything in Hard Mode as every character.