Full list of all 637 The Binding of Isaac: Rebirth achievements. It takes around 200 hours to unlock all of the achievements in the base game on Windows.
The base game contains 242 achievements, and there are 3 DLC packs containing 395 achievements.
111% now stop playing!
Unlocked a new item.
Unlocked a new co-player baby.
Unlocked a new character.
OMG!
New mode unlocked!
Alt stage to the basement.
Alt stage to the caves.
Alt stage to the depths.
Alt stage to the womb.
Unlocked new bosses!
Unlocked even more bosses!
Unlocked new enemies!
Unlocked Challenge #11.
Beat caves without taking damage.
Built him out of meat cubes.
Donated 600 pennies to the shop.
Beat womb without taking damage.
Unlocked Challenge #19.
Unlocked a new boss!
Beat depths without taking damage.
Beat Chest or Dark Room without taking damage.
New boss in the womb!
Isaac now holds the D6!
You are the best!!
Donated 200 pennies to the shop.
New boss in the basement!
They are waiting.
You became Lord of the Flies.
New boss in the caves!
New boss in the depths!
Your future's past waits.
Unlocked Challenge #4.
Unlocked Challenge #7.
Unlocked Challenge #9.
Donated 100 pennies to the shop.
Beat basement without taking damage.
The game just got harder!
Unlocked Challenge #6.
Unlocked Challenge #5.
Unlocked Challenge #10.
Unlocked another miniboss!
Donated 20 pennies to the shop.
Unlocked Challenge #8.
Destroy 100 rocks.
Chapter 4 - The Womb unlocked.
The horsemen are loose.
Unlocked Challenge #20.
Nerd x 1000000
Unlocked...
Unlocked a new starting item.
Unlocked a secret.
Greed just got harder!
Unlocked a new item
Unlocked Challenge #26.
Unlocked Challenge #27.
Unlocked Challenge #24.
Unlocked Challenge #23.
Unlocked a hidden chapter.
Unlocked Challenge #21.
Unlocked Challenge #22.
Unlocked Challenge #25.
Unlocked Challenge #28.
Unlocked Challenge #29.
Unlocked Challenge #30.
Unlocked the power of RERUN.
Unlocked super special rocks.
Unlocked a new area.
Unlocked a new challenge.
Make a new friend!
Beat Greed mode with Jacob and Esau.
Beat Greedier mode with Jacob and Esau.
Beat everything in Hard mode with Jacob and Esau.
Beat everything in Hard Mode as every character.
Complete ??? with Jacob and Esau.
Complete the Corpse with Jacob and Esau.
Complete the Corpse with Keeper.
Complete Boss Rush with Jacob and Esau.
Complete the Corpse with Lazarus.
Complete the Corpse with Eve.
Beat everything in Hard mode with Bethany.
Complete the Dark Room with Bethany.
Complete Sheol with Bethany.
Complete the Corpse with Judas.
Kill 10 Battery Bums.
Complete the Corpse with Bethany.
Complete the Corpse with Apollyon.
Complete the Void with Jacob and Esau.
Defeat Mega Satan with Jacob and Esau.
Complete the Chest with Jacob and Esau.
Complete the Cathedral with Jacob and Esau.
Complete the Corpse with Cain.
Complete the Corpse with Magdalene.
Complete the Corpse with Lilith.
Complete the Corpse with the Lost.
Complete the final chapter with the Lost.
Complete the final chapter with Eden.
Complete the final chapter with Samson.
Complete the final chapter with Lilith.
Complete the final chapter with Keeper.
Complete the final chapter with Lazarus.
Complete the final chapter with the Forgotten.
Complete the final chapter with Azazel.
Complete the Corpse with Samson.
Complete the final chapter with Eve.
Complete the final chapter with ???.
Complete the final chapter with Cain.
Complete the Corpse with ???.
Complete the final chapter with Magdalene.
Complete the Corpse with the Forgotten.
Get that song out of her head.
Complete the final chapter with Bethany.
Kill Hornfel before he escapes!
Complete the final chapter with Jacob and Esau.
Complete the Dark Room with Jacob and Esau.
Complete Sheol with Jacob and Esau.
Beat the game in Hard mode with Jacob and Esau.
Beat Greed mode with Bethany.
Beat Greedier mode with Bethany.
Complete the Corpse with Azazel.
Complete the Corpse with Eden.
Complete the final chapter with Isaac.
Complete the final chapter with Apollyon.
They will charge you up... for a small fee.
Complete the final chapter with Judas.
The other side is calling...
You are just like your father...
Complete the Corpse with Isaac.
Where could it lead to?
Enter the Corpse...
Defeat all bosses in the Mausoleum.
Defeat all bosses in the Mines.
Beat the Void with Bethany.
Defeat Mega Satan with Bethany.
Complete the Chest with Bethany.
Complete the Cathedral with Bethany.
Complete ??? with Bethany.
Defeat all bosses in Downpour.
Defeat Baby Plum 10 times.
Obtain 99 pennies. Then spend every single one of them.
Beat the game in Hard mode with Bethany.
Complete Boss Rush with Bethany.
Beat Hard mode as Lazarus without losing a life
Kids shouldn't believe in fortunes...
Spend 40+ pennies in a single shop.
Complete ??? 3 times.