Here is the full list of all 43 Prototype 2 achievements. It takes around 20-25 hours to unlock all of the achievements on Windows.
Fully upgrade Heller.
Complete the game on HARD difficulty.
Complete the game.
Acquire all 46 upgrades through Consumes.
Complete LABOR OF LOVE.
Complete all //BLACKNET dossiers.
Destroy 5 vehicles using a Finisher.
Destroy 10 Blackwatch tanks, APCs or helicopters using a single hijacked tank or APC.
Destroy 5 helicopters using Pack Leader.
Mount a helicopter using Whipfist.
Simultaneously kill 2 Brawlers using a single Devastator.
Stealth hijack 5 tanks or APCs.
Travel a half mile using only Wall Run, Glide, Jump and Air Dash.
Weaponize 10 vehicles.
10 or more kills with a single Black Hole attack.
Spend at least 25 consecutive seconds in the air (helicopters don't count).
Reach the highest point in the world.
Destroy all Lairs.
Defeat all Field Ops teams.
Find all BlackBoxes.
Acquire 30 upgrades through Consumes.
10 or more kills using a single Bio-Bomb.
Complete FALL FROM GRACE.
Consume 10 //BLACKNET targets.
Counter enemy attacks 20 times using Shield.
20 or more kills with a single Hammerfist dive attack.
Acquire a Mutation in each of the 5 categories.
Destroy a single Lair.
Acquire 10 upgrades through Consumes.
Stealth Consume 50 Blackwatch troopers.
Complete NATURAL SELECTION.
Dismember a Brawler.
Deflect 5 missiles at enemies using Shield Block.
Trigger 50 alerts.
5 consumes in 10 seconds or less.
Karate kick a helicopter.
Acquire 5 Mutations.
Destroy a Strike Team in 15 seconds or less.
Complete a //BLACKNET operation.
Acquire a Prototype Power.
Meet Father Guerra.
Complete RESURRECTION.
Complete MEET YOUR MAKER.