Full list of all 637 The Binding of Isaac: Rebirth achievements. It takes around 200 hours to unlock all of the achievements in the base game on Windows.
The base game contains 242 achievements, and there are 4 DLC packs containing 395 achievements.
OMG!
111% now stop playing!
Unlocked a new item.
Unlocked a new co-player baby.
Unlocked Challenge #11.
New mode unlocked!
Unlocked Challenge #4.
Unlocked a new character.
Beat Chest or Dark Room without taking damage.
Unlocked even more bosses!
Beat caves without taking damage.
Alt stage to the womb.
Donated 600 pennies to the shop.
You are the best!!
Unlocked new enemies!
New boss in the womb!
Unlocked new bosses!
They are waiting.
Isaac now holds the D6!
Alt stage to the depths.
Built him out of meat cubes.
New boss in the basement!
New boss in the caves!
Alt stage to the caves.
Beat womb without taking damage.
New boss in the depths!
Donated 200 pennies to the shop.
Your future's past waits.
Unlocked Challenge #7.
Unlocked Challenge #19.
Alt stage to the basement.
Unlocked another miniboss!
Unlocked Challenge #9.
Unlocked a new boss!
The game just got harder!
Unlocked Challenge #8.
You became Lord of the Flies.
Beat basement without taking damage.
Unlocked Challenge #6.
Beat depths without taking damage.
Unlocked Challenge #5.
Unlocked Challenge #10.
Donated 100 pennies to the shop.
Destroy 100 rocks.
The horsemen are loose.
Unlocked Challenge #20.
Chapter 4 - The Womb unlocked.
Donated 20 pennies to the shop.
Unlocked...
Unlocked a new starting item.
Nerd x 1000000
Unlocked a secret.
Greed just got harder!
Unlocked a new item
Unlocked Challenge #26.
Unlocked Challenge #27.
Unlocked Challenge #24.
Unlocked Challenge #23.
Unlocked a hidden chapter.
Unlocked Challenge #21.
Unlocked Challenge #22.
Unlocked Challenge #25.
Unlocked Challenge #28.
Unlocked Challenge #29.
Unlocked Challenge #30.
Unlocked the power of RERUN.
Unlocked a new challenge.
Unlocked a new area.
Unlocked super special rocks.
Beat Greed mode with Jacob and Esau.
Beat Greedier mode with Jacob and Esau.
Beat everything in Hard mode with Jacob and Esau.
Beat everything in Hard Mode as every character.
Complete the final chapter with Jacob and Esau.
Complete the Void with Jacob and Esau.
Complete ??? with Jacob and Esau.
Defeat Mega Satan with Jacob and Esau.
Complete Boss Rush with Jacob and Esau.
Complete the Corpse with Jacob and Esau.
Complete the Dark Room with Jacob and Esau.
Complete Sheol with Jacob and Esau.
Complete the Chest with Jacob and Esau.
Complete the Cathedral with Jacob and Esau.
Beat the game in Hard mode with Jacob and Esau.
Beat Greed mode with Bethany.
Beat Greedier mode with Bethany.
Beat everything in Hard mode with Bethany.
Complete the final chapter with Keeper.
Complete the Corpse with Keeper.
Complete ??? with Bethany.
Complete the Corpse with Bethany.
Complete the final chapter with Bethany.
Complete the Corpse with Apollyon.
Complete the Corpse with Lilith.
Complete the final chapter with Lilith.
Complete the Corpse with Eden.
Complete the Corpse with Lazarus.
Complete the Corpse with Azazel.
Complete the Corpse with ???.
Complete the Corpse with Samson.
Complete the final chapter with Apollyon.
Complete the Corpse with the Forgotten.
Complete the Corpse with the Lost.
Complete the final chapter with the Lost.
Beat the Void with Bethany.
Complete the Dark Room with Bethany.
Complete Sheol with Bethany.
Complete the Corpse with Eve.
Complete the Corpse with Judas.
Complete Boss Rush with Bethany.
Defeat Mega Satan with Bethany.
Complete the Chest with Bethany.
Complete the Cathedral with Bethany.
Beat the game in Hard mode with Bethany.
Complete the final chapter with the Forgotten.
Complete the final chapter with Eden.
Beat Hard mode as Lazarus without losing a life
Complete the final chapter with Lazarus.
Complete the final chapter with Azazel.
Complete the final chapter with Samson.
Complete the Corpse with Cain.
Complete the final chapter with Eve.
Complete the final chapter with ???.
Complete the Corpse with Magdalene.
Complete the final chapter with Judas.
Defeat all bosses in the Mausoleum.
Complete the final chapter with Cain.
Complete the final chapter with Isaac.
Kill 10 Battery Bums.
Complete the final chapter with Magdalene.
The other side is calling...
Defeat all bosses in the Mines.
They will charge you up... for a small fee.
You are just like your father...
Complete the Corpse with Isaac.
Where could it lead to?
Enter the Corpse...
Defeat all bosses in Downpour.
Kill Hornfel before he escapes!
Get that song out of her head.
Make a new friend!
Complete ??? 3 times.
Obtain 99 pennies. Then spend every single one of them.
Spend 40+ pennies in a single shop.
Defeat Baby Plum 10 times.
Kids shouldn't believe in fortunes...