Full list of all 637 The Binding of Isaac: Rebirth achievements. It takes around 200 hours to unlock all of the achievements in the base game on Windows.
The base game contains 242 achievements, and there are 4 DLC packs containing 395 achievements.
OMG!
111% now stop playing!
Unlocked a new item.
Unlocked even more bosses!
Unlocked a new co-player baby.
Unlocked another miniboss!
New boss in the womb!
Beat womb without taking damage.
Unlocked Challenge #11.
Unlocked new bosses!
You are the best!!
Alt stage to the womb.
New boss in the basement!
Donated 600 pennies to the shop.
Beat Chest or Dark Room without taking damage.
New boss in the caves!
Unlocked a new character.
Alt stage to the depths.
Isaac now holds the D6!
Unlocked Challenge #19.
They are waiting.
Unlocked new enemies!
Alt stage to the caves.
Your future's past waits.
Unlocked Challenge #4.
Unlocked Challenge #7.
Alt stage to the basement.
New boss in the depths!
Unlocked Challenge #9.
New mode unlocked!
The game just got harder!
Beat depths without taking damage.
Beat basement without taking damage.
Donated 200 pennies to the shop.
Beat caves without taking damage.
Unlocked Challenge #6.
Unlocked a new boss!
Built him out of meat cubes.
Donated 100 pennies to the shop.
Unlocked Challenge #8.
You became Lord of the Flies.
The horsemen are loose.
Unlocked Challenge #20.
Chapter 4 - The Womb unlocked.
Destroy 100 rocks.
Unlocked Challenge #5.
Unlocked Challenge #10.
Donated 20 pennies to the shop.
Unlocked...
Unlocked a new item
Unlocked Challenge #24.
Nerd x 1000000
Unlocked a new starting item.
Unlocked Challenge #27.
Unlocked Challenge #26.
Unlocked Challenge #23.
Unlocked a hidden chapter.
Unlocked a secret.
Greed just got harder!
Unlocked Challenge #21.
Unlocked Challenge #22.
Unlocked Challenge #25.
Unlocked Challenge #28.
Unlocked Challenge #29.
Unlocked Challenge #30.
Unlocked the power of RERUN.
Unlocked a new challenge.
Unlocked a new area.
Unlocked super special rocks.
Beat everything in Hard Mode as every character.
Complete the Corpse with Cain.
Complete the Corpse with Judas.
Complete the final chapter with Judas.
Complete the Corpse with ???.
Complete the Corpse with Samson.
Complete the Corpse with Eve.
Complete the final chapter with Lazarus.
Complete the Corpse with Lazarus.
Complete the final chapter with Lilith.
Complete the Corpse with Keeper.
Complete the final chapter with Keeper.
Complete the Corpse with Apollyon.
Beat the Void with Bethany.
Beat everything in Hard mode with Bethany.
Complete the Chest with Bethany.
Complete the Cathedral with Bethany.
Complete ??? with Bethany.
Beat everything in Hard mode with Jacob and Esau.
Complete the Dark Room with Jacob and Esau.
Complete Sheol with Jacob and Esau.
Complete the final chapter with Jacob and Esau.
Complete the Corpse with Jacob and Esau.
Beat Greedier mode with Bethany.
Beat Greed mode with Bethany.
Beat Greedier mode with Jacob and Esau.
Beat Greed mode with Jacob and Esau.
Kill 10 Battery Bums.
Complete the Corpse with Magdalene.
Defeat Mega Satan with Bethany.
Complete the Dark Room with Bethany.
Complete Sheol with Bethany.
Complete the Corpse with the Forgotten.
Complete the final chapter with the Lost.
Complete the Corpse with the Lost.
Complete the final chapter with Eve.
Complete the Corpse with Lilith.
Complete the Corpse with Isaac.
Complete the final chapter with Magdalene.
They will charge you up... for a small fee.
Complete the final chapter with ???.
Complete the final chapter with Azazel.
Complete the final chapter with Apollyon.
Get that song out of her head.
Complete the Corpse with Bethany.
Beat the game in Hard mode with Bethany.
Defeat all bosses in the Mausoleum.
Complete the final chapter with Isaac.
Complete the Corpse with Eden.
Complete the final chapter with Samson.
Complete the final chapter with Bethany.
Complete Boss Rush with Bethany.
Complete the final chapter with Eden.
Defeat Baby Plum 10 times.
Obtain 99 pennies. Then spend every single one of them.
Complete the Void with Jacob and Esau.
Defeat Mega Satan with Jacob and Esau.
Complete the Chest with Jacob and Esau.
Complete the Cathedral with Jacob and Esau.
Complete ??? with Jacob and Esau.
Beat the game in Hard mode with Jacob and Esau.
Complete Boss Rush with Jacob and Esau.
Complete the final chapter with Cain.
Complete the final chapter with the Forgotten.
Kids shouldn't believe in fortunes...
The other side is calling...
You are just like your father...
Where could it lead to?
Complete the Corpse with Azazel.
Defeat all bosses in the Mines.
Kill Hornfel before he escapes!
Beat Hard mode as Lazarus without losing a life
Enter the Corpse...
Defeat all bosses in Downpour.
Make a new friend!
Complete ??? 3 times.
Spend 40+ pennies in a single shop.