Full list of all 637 The Binding of Isaac: Rebirth achievements. It takes around 200 hours to unlock all of the achievements in the base game on Windows.
The base game contains 242 achievements, and there are 4 DLC packs containing 395 achievements.
111% now stop playing!
OMG!
Unlocked a new item.
Unlocked a new co-player baby.
Built him out of meat cubes.
Unlocked even more bosses!
New mode unlocked!
Unlocked a new character.
Unlocked new enemies!
Alt stage to the womb.
Alt stage to the depths.
Unlocked new bosses!
Alt stage to the basement.
Alt stage to the caves.
Unlocked Challenge #11.
Unlocked Challenge #8.
Isaac now holds the D6!
Beat caves without taking damage.
Unlocked Challenge #19.
New boss in the womb!
Beat Chest or Dark Room without taking damage.
Beat womb without taking damage.
You are the best!!
They are waiting.
Beat depths without taking damage.
You became Lord of the Flies.
Donated 600 pennies to the shop.
New boss in the depths!
New boss in the caves!
Your future's past waits.
Unlocked Challenge #4.
Unlocked Challenge #7.
Unlocked a new boss!
Unlocked Challenge #9.
New boss in the basement!
Donated 200 pennies to the shop.
The game just got harder!
Beat basement without taking damage.
Unlocked another miniboss!
Unlocked Challenge #6.
Donated 100 pennies to the shop.
Unlocked Challenge #5.
Unlocked Challenge #10.
Destroy 100 rocks.
Donated 20 pennies to the shop.
The horsemen are loose.
Unlocked Challenge #20.
Chapter 4 - The Womb unlocked.
Unlocked...
Unlocked a new starting item.
Unlocked a new item
Nerd x 1000000
Unlocked a secret.
Greed just got harder!
Unlocked Challenge #24.
Unlocked Challenge #26.
Unlocked Challenge #27.
Unlocked Challenge #23.
Unlocked a hidden chapter.
Unlocked Challenge #21.
Unlocked Challenge #22.
Unlocked Challenge #25.
Unlocked Challenge #28.
Unlocked Challenge #29.
Unlocked Challenge #30.
Unlocked the power of RERUN.
Unlocked super special rocks.
Unlocked a new challenge.
Unlocked a new area.
Beat everything in Hard mode with Jacob and Esau.
Complete the final chapter with Jacob and Esau.
Beat everything in Hard Mode as every character.
Complete ??? with Jacob and Esau.
Complete Boss Rush with Jacob and Esau.
Complete the Corpse with Jacob and Esau.
Beat Greedier mode with Jacob and Esau.
Beat Greed mode with Jacob and Esau.
Complete the Void with Jacob and Esau.
Defeat Mega Satan with Jacob and Esau.
Complete the Dark Room with Jacob and Esau.
Complete Sheol with Jacob and Esau.
Complete the Chest with Jacob and Esau.
Complete the Cathedral with Jacob and Esau.
Beat the game in Hard mode with Jacob and Esau.
Complete the Corpse with Lilith.
Get that song out of her head.
Complete the final chapter with Apollyon.
Complete the final chapter with Keeper.
Complete the Corpse with Keeper.
Complete the Corpse with the Forgotten.
Complete the final chapter with Lazarus.
Complete the Corpse with Azazel.
Complete the final chapter with Azazel.
Complete the Corpse with ???.
Complete the final chapter with Samson.
Complete the final chapter with Isaac.
Beat everything in Hard mode with Bethany.
Beat the Void with Bethany.
Defeat Mega Satan with Bethany.
Beat Greedier mode with Bethany.
Complete the final chapter with Bethany.
Complete Boss Rush with Bethany.
Complete the Corpse with the Lost.
Complete the final chapter with the Lost.
They will charge you up... for a small fee.
Complete the Corpse with Apollyon.
Complete the Corpse with Eve.
Complete the Corpse with Lazarus.
Complete the Corpse with Bethany.
Complete the Corpse with Cain.
Complete the Corpse with Magdalene.
Kill 10 Battery Bums.
Complete the Corpse with Judas.
Complete the Corpse with Samson.
Complete the Corpse with Isaac.
Defeat all bosses in the Mausoleum.
Complete the final chapter with Lilith.
Complete the final chapter with ???.
Complete the final chapter with the Forgotten.
Obtain 99 pennies. Then spend every single one of them.
Complete the final chapter with Magdalene.
Complete the final chapter with Eve.
Complete the final chapter with Cain.
Complete the final chapter with Judas.
Complete the final chapter with Eden.
Defeat all bosses in the Mines.
Kill Hornfel before he escapes!
Defeat all bosses in Downpour.
The other side is calling...
Beat Greed mode with Bethany.
You are just like your father...
Where could it lead to?
Complete the Corpse with Eden.
Enter the Corpse...
Complete ??? 3 times.
Complete the Dark Room with Bethany.
Complete Sheol with Bethany.
Complete ??? with Bethany.
Beat the game in Hard mode with Bethany.
Complete the Chest with Bethany.
Complete the Cathedral with Bethany.
Make a new friend!
Beat Hard mode as Lazarus without losing a life
Defeat Baby Plum 10 times.
Kids shouldn't believe in fortunes...
Spend 40+ pennies in a single shop.