Full list of all 637 The Binding of Isaac: Rebirth achievements. It takes around 200 hours to unlock all of the achievements in the base game on Windows.
The base game contains 242 achievements, and there are 3 DLC packs containing 395 achievements.
Unlocked a new item.
OMG!
111% now stop playing!
Unlocked Challenge #4.
Unlocked a new co-player baby.
Unlocked even more bosses!
Unlocked Challenge #11.
Built him out of meat cubes.
Beat Chest or Dark Room without taking damage.
Unlocked new bosses!
New boss in the womb!
Alt stage to the womb.
Unlocked a new character.
New mode unlocked!
Isaac now holds the D6!
You are the best!!
You became Lord of the Flies.
Alt stage to the depths.
New boss in the caves!
Alt stage to the caves.
New boss in the depths!
Donated 600 pennies to the shop.
Unlocked Challenge #7.
Unlocked Challenge #19.
Alt stage to the basement.
Your future's past waits.
Unlocked a new boss!
New boss in the basement!
Unlocked Challenge #9.
The game just got harder!
Beat womb without taking damage.
Beat depths without taking damage.
Beat caves without taking damage.
They are waiting.
Unlocked new enemies!
Donated 200 pennies to the shop.
Unlocked Challenge #6.
Unlocked another miniboss!
Beat basement without taking damage.
Unlocked Challenge #8.
Donated 100 pennies to the shop.
The horsemen are loose.
Unlocked Challenge #20.
Chapter 4 - The Womb unlocked.
Donated 20 pennies to the shop.
Destroy 100 rocks.
Unlocked Challenge #5.
Unlocked Challenge #10.
Unlocked...
Unlocked a new starting item.
Nerd x 1000000
Unlocked Challenge #24.
Unlocked Challenge #26.
Unlocked a secret.
Greed just got harder!
Unlocked a new item
Unlocked Challenge #27.
Unlocked Challenge #23.
Unlocked a hidden chapter.
Unlocked Challenge #21.
Unlocked Challenge #22.
Unlocked Challenge #25.
Unlocked Challenge #28.
Unlocked Challenge #29.
Unlocked Challenge #30.
Unlocked the power of RERUN.
Unlocked super special rocks.
Unlocked a new challenge.
Unlocked a new area.
Complete Sheol with Bethany.
Complete the Dark Room with Bethany.
Beat Greed mode with Bethany.
Beat Greedier mode with Bethany.
Beat the Void with Bethany.
Beat everything in Hard mode with Bethany.
Beat the game in Hard mode with Jacob and Esau.
Complete the Cathedral with Jacob and Esau.
Complete Sheol with Jacob and Esau.
Complete the Chest with Jacob and Esau.
Complete the Dark Room with Jacob and Esau.
Complete Boss Rush with Jacob and Esau.
Beat Greed mode with Jacob and Esau.
Complete ??? with Jacob and Esau.
Beat Greedier mode with Jacob and Esau.
Complete the Void with Jacob and Esau.
Beat everything in Hard mode with Jacob and Esau.
Defeat Mega Satan with Jacob and Esau.
Complete the Corpse with Cain.
Complete the final chapter with ???.
Complete the Corpse with Eve.
Complete the Corpse with Samson.
Complete the final chapter with Samson.
Complete the Corpse with Lazarus.
Complete the final chapter with Lazarus.
Complete the final chapter with Lilith.
Complete the Corpse with Apollyon.
Complete the Corpse with the Forgotten.
Complete the final chapter with the Forgotten.
Complete the Corpse with Bethany.
Complete the final chapter with Bethany.
Complete the Corpse with Jacob and Esau.
Complete the final chapter with Jacob and Esau.
Beat everything in Hard Mode as every character.
Complete the Corpse with Azazel.
Complete the final chapter with Judas.
Complete the Corpse with Judas.
Complete the Corpse with Lilith.
Complete the final chapter with Keeper.
Complete the Corpse with Keeper.
Complete the final chapter with Azazel.
Complete the final chapter with Apollyon.
Kill 10 Battery Bums.
Complete the final chapter with Magdalene.
Complete the Corpse with Magdalene.
They will charge you up... for a small fee.
Get that song out of her head.
Defeat Mega Satan with Bethany.
Complete the Chest with Bethany.
Complete the Cathedral with Bethany.
Complete ??? with Bethany.
Beat the game in Hard mode with Bethany.
Complete Boss Rush with Bethany.
Beat Hard mode as Lazarus without losing a life
Complete the final chapter with the Lost.
Defeat all bosses in the Mines.
Complete the final chapter with Isaac.
Complete the Corpse with Isaac.
Complete the Corpse with the Lost.
Complete the final chapter with Eden.
Complete the Corpse with ???.
Kids shouldn't believe in fortunes...
Complete the final chapter with Cain.
Complete the final chapter with Eve.
The other side is calling...
Defeat all bosses in Downpour.
Defeat all bosses in the Mausoleum.
You are just like your father...
Complete the Corpse with Eden.
Where could it lead to?
Enter the Corpse...
Kill Hornfel before he escapes!
Complete ??? 3 times.
Make a new friend!
Defeat Baby Plum 10 times.
Obtain 99 pennies. Then spend every single one of them.
Spend 40+ pennies in a single shop.