Full list of all 637 The Binding of Isaac: Rebirth achievements. It takes around 200 hours to unlock all of the achievements in the base game on Windows.
The base game contains 242 achievements, and there are 4 DLC packs containing 395 achievements.
OMG!
111% now stop playing!
Unlocked a new item.
Unlocked a new co-player baby.
Unlocked a new character.
Beat Chest or Dark Room without taking damage.
New mode unlocked!
Beat depths without taking damage.
Beat caves without taking damage.
Donated 600 pennies to the shop.
You are the best!!
Unlocked new enemies!
Built him out of meat cubes.
Alt stage to the womb.
Donated 200 pennies to the shop.
Beat womb without taking damage.
Unlocked even more bosses!
You became Lord of the Flies.
Donated 100 pennies to the shop.
Chapter 4 - The Womb unlocked.
The horsemen are loose.
New boss in the basement!
New boss in the caves!
New boss in the depths!
Isaac now holds the D6!
The game just got harder!
Your future's past waits.
Beat basement without taking damage.
Unlocked a new boss!
New boss in the womb!
Destroy 100 rocks.
Alt stage to the basement.
Alt stage to the caves.
Alt stage to the depths.
Unlocked another miniboss!
Donated 20 pennies to the shop.
They are waiting.
Unlocked Challenge #4.
Unlocked Challenge #5.
Unlocked Challenge #6.
Unlocked Challenge #7.
Unlocked Challenge #8.
Unlocked Challenge #9.
Unlocked Challenge #10.
Unlocked Challenge #11.
Unlocked Challenge #19.
Unlocked Challenge #20.
Unlocked new bosses!
Unlocked...
Unlocked a new starting item.
Nerd x 1000000
Unlocked a new item
Unlocked Challenge #26.
Unlocked a secret.
Greed just got harder!
Unlocked Challenge #24.
Unlocked a hidden chapter.
Unlocked Challenge #21.
Unlocked Challenge #22.
Unlocked Challenge #23.
Unlocked Challenge #25.
Unlocked Challenge #27.
Unlocked Challenge #28.
Unlocked Challenge #29.
Unlocked Challenge #30.
Unlocked the power of RERUN.
Unlocked super special rocks.
Unlocked a new challenge.
Unlocked a new area.
They will charge you up... for a small fee.
Beat everything in Hard Mode as every character.
Complete the Void with Jacob and Esau.
Beat everything in Hard mode with Jacob and Esau.
Beat everything in Hard mode with Bethany.
Beat the Void with Bethany.
Complete the final chapter with Jacob and Esau.
Complete the Corpse with Jacob and Esau.
Defeat Mega Satan with Jacob and Esau.
Complete the Dark Room with Jacob and Esau.
Complete ??? with Jacob and Esau.
Beat Greed mode with Jacob and Esau.
Beat Greedier mode with Jacob and Esau.
Complete the final chapter with Bethany.
Complete the Corpse with Bethany.
Complete the Corpse with Apollyon.
Complete the final chapter with the Forgotten.
Complete the Corpse with the Forgotten.
Complete the final chapter with Keeper.
Complete the Corpse with Keeper.
Complete the Corpse with Eden.
Complete the Corpse with Lazarus.
Complete the final chapter with Lilith.
Complete the Corpse with Samson.
Kill Hornfel before he escapes!
Complete the final chapter with Samson.
Complete the Corpse with Eve.
Complete the Corpse with ???.
Complete the Corpse with Judas.
Complete the Corpse with Cain.
Complete the Corpse with Magdalene.
Complete the Corpse with Isaac.
Complete the final chapter with Apollyon.
Complete the final chapter with Eden.
Complete the final chapter with Lazarus.
Complete the final chapter with Azazel.
Complete the Corpse with Azazel.
Complete the final chapter with Eve.
Complete the final chapter with ???.
Complete the final chapter with Judas.
Complete the final chapter with Cain.
Complete the final chapter with Magdalene.
Defeat all bosses in the Mines.
Complete the final chapter with Isaac.
Complete the Chest with Jacob and Esau.
Complete the Cathedral with Jacob and Esau.
Complete the Corpse with the Lost.
Complete the final chapter with the Lost.
Complete Sheol with Jacob and Esau.
Defeat all bosses in the Mausoleum.
Beat the game in Hard mode with Jacob and Esau.
Complete Boss Rush with Jacob and Esau.
Defeat Mega Satan with Bethany.
Complete the Dark Room with Bethany.
Complete ??? with Bethany.
Complete Sheol with Bethany.
Complete Boss Rush with Bethany.
The other side is calling...
You are just like your father...
Where could it lead to?
Complete the Corpse with Lilith.
Enter the Corpse...
Get that song out of her head.
Defeat all bosses in Downpour.
Beat Greed mode with Bethany.
Beat Greedier mode with Bethany.
Complete the Chest with Bethany.
Complete the Cathedral with Bethany.
Beat the game in Hard mode with Bethany.
Kill 10 Battery Bums.
Beat Hard mode as Lazarus without losing a life
Complete ??? 3 times.
Obtain 99 pennies. Then spend every single one of them.
Kids shouldn't believe in fortunes...
Defeat Baby Plum 10 times.
Make a new friend!
Spend 40+ pennies in a single shop.