Full list of all 637 The Binding of Isaac: Rebirth achievements. It takes around 200 hours to unlock all of the achievements in the base game on Windows.
The base game contains 242 achievements, and there are 4 DLC packs containing 395 achievements.
Unlocked a new item.
OMG!
111% now stop playing!
Unlocked a new co-player baby.
Unlocked a new character.
Unlocked Challenge #11.
Beat Chest or Dark Room without taking damage.
Unlocked Challenge #4.
New mode unlocked!
Unlocked even more bosses!
Donated 600 pennies to the shop.
Unlocked new bosses!
Built him out of meat cubes.
New boss in the womb!
Alt stage to the womb.
You became Lord of the Flies.
You are the best!!
Unlocked new enemies!
Unlocked Challenge #19.
They are waiting.
Alt stage to the depths.
Isaac now holds the D6!
New boss in the caves!
Unlocked a new boss!
New boss in the basement!
Beat womb without taking damage.
Alt stage to the caves.
Beat caves without taking damage.
Unlocked Challenge #8.
Your future's past waits.
Unlocked Challenge #7.
Alt stage to the basement.
New boss in the depths!
Donated 200 pennies to the shop.
Unlocked Challenge #9.
Beat depths without taking damage.
Unlocked another miniboss!
Donated 100 pennies to the shop.
The game just got harder!
Beat basement without taking damage.
Unlocked Challenge #5.
Unlocked Challenge #10.
Unlocked Challenge #6.
Donated 20 pennies to the shop.
Destroy 100 rocks.
Chapter 4 - The Womb unlocked.
The horsemen are loose.
Unlocked Challenge #20.
Unlocked...
Unlocked a new item
Unlocked a new starting item.
Nerd x 1000000
Unlocked a secret.
Greed just got harder!
Unlocked Challenge #26.
Unlocked Challenge #27.
Unlocked Challenge #24.
Unlocked Challenge #23.
Unlocked a hidden chapter.
Unlocked Challenge #21.
Unlocked Challenge #22.
Unlocked Challenge #25.
Unlocked Challenge #28.
Unlocked Challenge #29.
Unlocked Challenge #30.
Unlocked the power of RERUN.
Unlocked a new challenge.
Unlocked a new area.
Unlocked super special rocks.
They will charge you up... for a small fee.
Beat everything in Hard mode with Jacob and Esau.
Beat everything in Hard Mode as every character.
Complete the Corpse with Jacob and Esau.
Defeat Mega Satan with Jacob and Esau.
Complete the Dark Room with Jacob and Esau.
Complete ??? with Jacob and Esau.
Complete Sheol with Jacob and Esau.
Beat Greed mode with Jacob and Esau.
Beat Greedier mode with Jacob and Esau.
Beat everything in Hard mode with Bethany.
Complete the Corpse with Bethany.
Get that song out of her head.
Complete the Chest with Bethany.
Complete the Cathedral with Bethany.
Beat Greedier mode with Bethany.
Beat Greed mode with Bethany.
Beat the Void with Bethany.
Defeat Mega Satan with Bethany.
Complete the Dark Room with Bethany.
Complete Sheol with Bethany.
Complete the Corpse with Apollyon.
Complete the Void with Jacob and Esau.
Complete the Chest with Jacob and Esau.
Complete the Cathedral with Jacob and Esau.
Complete ??? with Bethany.
Beat the game in Hard mode with Bethany.
Complete Boss Rush with Bethany.
Complete the Corpse with Keeper.
Complete the Corpse with Lilith.
Complete the Corpse with Eden.
Complete the final chapter with Eden.
Complete the Corpse with Lazarus.
Complete the Corpse with Azazel.
Complete the Corpse with Samson.
Complete the Corpse with Eve.
Complete the Corpse with ???.
Complete the final chapter with Judas.
Complete the Corpse with Judas.
Complete the Corpse with Cain.
Complete the Corpse with Magdalene.
Kill 10 Battery Bums.
Complete the final chapter with Magdalene.
Complete the Corpse with the Forgotten.
Complete the Corpse with the Lost.
Complete the final chapter with Jacob and Esau.
Complete Boss Rush with Jacob and Esau.
Beat the game in Hard mode with Jacob and Esau.
Complete the final chapter with the Lost.
Kill Hornfel before he escapes!
Make a new friend!
Complete the final chapter with Lilith.
Complete the final chapter with Keeper.
Complete the final chapter with Apollyon.
Complete the final chapter with Bethany.
Complete the final chapter with the Forgotten.
Complete the final chapter with Lazarus.
Complete the final chapter with Azazel.
Complete the final chapter with Samson.
Complete the final chapter with Eve.
Defeat all bosses in the Mausoleum.
Complete the final chapter with Cain.
Kids shouldn't believe in fortunes...
Complete the final chapter with ???.
Beat Hard mode as Lazarus without losing a life
Complete the final chapter with Isaac.
The other side is calling...
You are just like your father...
Where could it lead to?
Complete the Corpse with Isaac.
Defeat all bosses in the Mines.
Enter the Corpse...
Defeat all bosses in Downpour.
Obtain 99 pennies. Then spend every single one of them.
Complete ??? 3 times.
Defeat Baby Plum 10 times.
Spend 40+ pennies in a single shop.