Full list of all 637 The Binding of Isaac: Rebirth achievements. It takes around 200 hours to unlock all of the achievements in the base game on Windows.
The base game contains 242 achievements, and there are 4 DLC packs containing 395 achievements.
Unlocked a new item.
OMG!
111% now stop playing!
Unlocked Challenge #11.
Unlocked a new co-player baby.
New mode unlocked!
Unlocked Challenge #8.
Donated 600 pennies to the shop.
Unlocked a new character.
Unlocked even more bosses!
Beat womb without taking damage.
Beat depths without taking damage.
You are the best!!
Unlocked new enemies!
Alt stage to the womb.
New boss in the womb!
Unlocked new bosses!
Alt stage to the basement.
Alt stage to the caves.
Alt stage to the depths.
Unlocked Challenge #19.
You became Lord of the Flies.
Beat Chest or Dark Room without taking damage.
They are waiting.
Unlocked a new boss!
New boss in the basement!
New boss in the caves!
Donated 200 pennies to the shop.
Isaac now holds the D6!
New boss in the depths!
Your future's past waits.
Unlocked Challenge #4.
Unlocked Challenge #7.
Beat caves without taking damage.
Unlocked Challenge #9.
Donated 100 pennies to the shop.
Unlocked another miniboss!
The game just got harder!
Unlocked Challenge #6.
Donated 20 pennies to the shop.
Built him out of meat cubes.
Beat basement without taking damage.
Destroy 100 rocks.
The horsemen are loose.
Unlocked Challenge #20.
Chapter 4 - The Womb unlocked.
Unlocked Challenge #5.
Unlocked Challenge #10.
Unlocked...
Unlocked a new starting item.
Unlocked a new item
Nerd x 1000000
Unlocked a secret.
Greed just got harder!
Unlocked Challenge #24.
Unlocked Challenge #26.
Unlocked Challenge #27.
Unlocked Challenge #23.
Unlocked a hidden chapter.
Unlocked Challenge #21.
Unlocked Challenge #22.
Unlocked Challenge #25.
Unlocked Challenge #28.
Unlocked Challenge #29.
Unlocked Challenge #30.
Unlocked super special rocks.
Unlocked the power of RERUN.
Unlocked a new area.
Unlocked a new challenge.
Complete the Dark Room with Jacob and Esau.
Beat everything in Hard mode with Jacob and Esau.
Beat everything in Hard Mode as every character.
Complete Sheol with Jacob and Esau.
Complete the Corpse with Jacob and Esau.
Complete the Void with Jacob and Esau.
Complete ??? with Jacob and Esau.
Complete the final chapter with Jacob and Esau.
Beat Greed mode with Jacob and Esau.
Beat Greedier mode with Jacob and Esau.
Defeat Mega Satan with Jacob and Esau.
Complete the Chest with Jacob and Esau.
Complete the Cathedral with Jacob and Esau.
Complete Boss Rush with Jacob and Esau.
Beat the game in Hard mode with Jacob and Esau.
Beat the Void with Bethany.
Beat everything in Hard mode with Bethany.
Complete the Corpse with the Forgotten.
Complete the Corpse with Apollyon.
Complete the final chapter with Apollyon.
Complete the Corpse with Keeper.
Complete the final chapter with Keeper.
Complete the Corpse with Lilith.
Complete the final chapter with Lilith.
Complete the Corpse with the Lost.
Kill 10 Battery Bums.
Complete the final chapter with the Lost.
Complete the Corpse with Eden.
Complete the final chapter with Eden.
They will charge you up... for a small fee.
Complete the final chapter with Lazarus.
Complete the Corpse with Lazarus.
Complete the final chapter with Samson.
Complete the Corpse with Samson.
Complete the Corpse with Eve.
Complete the final chapter with Eve.
Complete the Corpse with Judas.
Complete the Corpse with Cain.
Complete the Corpse with Magdalene.
Complete the final chapter with Magdalene.
Complete the Corpse with ???.
Beat Greedier mode with Bethany.
Complete the Corpse with Bethany.
Complete the Corpse with Isaac.
Complete the final chapter with Isaac.
Defeat Mega Satan with Bethany.
Complete the Dark Room with Bethany.
Complete Sheol with Bethany.
Complete ??? with Bethany.
Complete Boss Rush with Bethany.
Complete the Chest with Bethany.
Complete the Cathedral with Bethany.
Beat the game in Hard mode with Bethany.
Complete the final chapter with Bethany.
Beat Greed mode with Bethany.
Beat Hard mode as Lazarus without losing a life
Complete the final chapter with the Forgotten.
Obtain 99 pennies. Then spend every single one of them.
Kids shouldn't believe in fortunes...
Defeat Baby Plum 10 times.
Complete the final chapter with ???.
Complete the final chapter with Judas.
Complete the final chapter with Cain.
Make a new friend!
Complete the final chapter with Azazel.
The other side is calling...
You are just like your father...
Complete the Corpse with Azazel.
Where could it lead to?
Defeat all bosses in the Mines.
Kill Hornfel before he escapes!
Spend 40+ pennies in a single shop.
Enter the Corpse...
Defeat all bosses in the Mausoleum.
Defeat all bosses in Downpour.
Get that song out of her head.
Complete ??? 3 times.