Full list of all 637 The Binding of Isaac: Rebirth achievements. It takes around 200 hours to unlock all of the achievements in the base game on Windows.
The base game contains 242 achievements, and there are 3 DLC packs containing 395 achievements.
Unlocked a new item.
OMG!
111% now stop playing!
Donated 600 pennies to the shop.
Unlocked a new co-player baby.
Unlocked Challenge #11.
Unlocked a new character.
New mode unlocked!
Unlocked Challenge #19.
Donated 200 pennies to the shop.
You are the best!!
Unlocked new enemies!
Built him out of meat cubes.
Alt stage to the basement.
Alt stage to the caves.
Alt stage to the depths.
Alt stage to the womb.
Unlocked new bosses!
Unlocked even more bosses!
New boss in the womb!
Beat depths without taking damage.
Beat basement without taking damage.
Beat Chest or Dark Room without taking damage.
Isaac now holds the D6!
They are waiting.
Beat womb without taking damage.
Unlocked a new boss!
Donated 100 pennies to the shop.
Donated 20 pennies to the shop.
Unlocked Challenge #4.
Unlocked Challenge #7.
Your future's past waits.
New boss in the caves!
Unlocked Challenge #9.
New boss in the depths!
Unlocked Challenge #8.
You became Lord of the Flies.
New boss in the basement!
The game just got harder!
Beat caves without taking damage.
Unlocked Challenge #6.
Unlocked another miniboss!
Chapter 4 - The Womb unlocked.
The horsemen are loose.
Unlocked Challenge #20.
Destroy 100 rocks.
Unlocked Challenge #5.
Unlocked Challenge #10.
Unlocked...
Unlocked a new starting item.
Unlocked a new item
Nerd x 1000000
Unlocked a secret.
Greed just got harder!
Unlocked Challenge #26.
Unlocked Challenge #27.
Unlocked Challenge #24.
Unlocked Challenge #23.
Unlocked a hidden chapter.
Unlocked Challenge #21.
Unlocked Challenge #22.
Unlocked Challenge #25.
Unlocked Challenge #28.
Unlocked Challenge #29.
Unlocked Challenge #30.
Unlocked the power of RERUN.
Unlocked super special rocks.
Unlocked a new challenge.
Unlocked a new area.
Beat everything in Hard Mode as every character.
Beat Greed mode with Jacob and Esau.
Beat Greedier mode with Jacob and Esau.
Beat everything in Hard mode with Jacob and Esau.
Defeat Mega Satan with Jacob and Esau.
Complete the Corpse with Jacob and Esau.
Complete the Void with Jacob and Esau.
Complete ??? with Jacob and Esau.
Complete the Corpse with the Forgotten.
Complete the Corpse with Apollyon.
Complete the final chapter with Apollyon.
Complete the Corpse with Keeper.
Complete the Corpse with Lilith.
Complete the Corpse with Lazarus.
Complete the final chapter with Lazarus.
Complete the Corpse with Azazel.
Complete the final chapter with Azazel.
Complete the Corpse with Samson.
Complete the Corpse with Eve.
Complete the Dark Room with Jacob and Esau.
Complete Sheol with Jacob and Esau.
Complete the Chest with Jacob and Esau.
Complete the Cathedral with Jacob and Esau.
Beat the game in Hard mode with Jacob and Esau.
They will charge you up... for a small fee.
Complete the Corpse with Eden.
Complete the final chapter with Eden.
Complete Boss Rush with Jacob and Esau.
Complete the final chapter with Jacob and Esau.
Beat Greedier mode with Bethany.
Beat everything in Hard mode with Bethany.
Beat Greed mode with Bethany.
Complete the Corpse with Bethany.
Complete the Dark Room with Bethany.
Complete Sheol with Bethany.
Defeat Mega Satan with Bethany.
Beat the Void with Bethany.
Complete ??? with Bethany.
Complete Boss Rush with Bethany.
Complete the final chapter with ???.
Complete the Corpse with ???.
Complete the Corpse with the Lost.
Complete the final chapter with the Lost.
Complete the final chapter with Keeper.
Obtain 99 pennies. Then spend every single one of them.
Complete the Corpse with Magdalene.
Complete the final chapter with Magdalene.
Complete the Corpse with Isaac.
Complete the final chapter with Isaac.
Complete the final chapter with Cain.
Complete the Corpse with Cain.
Complete the final chapter with the Forgotten.
Complete the final chapter with Bethany.
Complete the final chapter with Lilith.
Complete the final chapter with Samson.
Complete the final chapter with Eve.
Complete the final chapter with Judas.
Kids shouldn't believe in fortunes...
Kill 10 Battery Bums.
The other side is calling...
You are just like your father...
Complete the Corpse with Judas.
Where could it lead to?
Make a new friend!
Defeat Baby Plum 10 times.
Spend 40+ pennies in a single shop.
Enter the Corpse...
Complete the Chest with Bethany.
Complete the Cathedral with Bethany.
Beat the game in Hard mode with Bethany.
Beat Hard mode as Lazarus without losing a life
Defeat all bosses in the Mausoleum.
Defeat all bosses in the Mines.
Kill Hornfel before he escapes!
Defeat all bosses in Downpour.
Get that song out of her head.
Complete ??? 3 times.