Full list of all 637 The Binding of Isaac: Rebirth achievements. It takes around 200 hours to unlock all of the achievements in the base game on Windows.
The base game contains 242 achievements, and there are 4 DLC packs containing 395 achievements.
Unlocked a new item.
111% now stop playing!
OMG!
Beat Chest or Dark Room without taking damage.
Unlocked a new co-player baby.
Unlocked even more bosses!
New boss in the womb!
Unlocked new bosses!
Unlocked a new character.
New mode unlocked!
You are the best!!
Donated 600 pennies to the shop.
Unlocked Challenge #11.
They are waiting.
Unlocked new enemies!
Alt stage to the womb.
Donated 200 pennies to the shop.
Alt stage to the depths.
Isaac now holds the D6!
Beat womb without taking damage.
Alt stage to the caves.
New boss in the caves!
Beat depths without taking damage.
Beat caves without taking damage.
Unlocked a new boss!
Beat basement without taking damage.
New boss in the basement!
New boss in the depths!
Donated 100 pennies to the shop.
Your future's past waits.
Unlocked Challenge #4.
Unlocked Challenge #7.
Unlocked Challenge #19.
Alt stage to the basement.
Unlocked Challenge #9.
You became Lord of the Flies.
The game just got harder!
Unlocked Challenge #8.
Unlocked Challenge #5.
Unlocked Challenge #10.
Unlocked Challenge #6.
Donated 20 pennies to the shop.
Unlocked another miniboss!
Built him out of meat cubes.
Chapter 4 - The Womb unlocked.
The horsemen are loose.
Unlocked Challenge #20.
Destroy 100 rocks.
Unlocked...
Unlocked a new starting item.
Nerd x 1000000
Unlocked Challenge #27.
Unlocked a new item
Unlocked Challenge #26.
Unlocked a secret.
Greed just got harder!
Unlocked Challenge #24.
Unlocked Challenge #23.
Unlocked a hidden chapter.
Unlocked Challenge #21.
Unlocked Challenge #22.
Unlocked Challenge #25.
Unlocked Challenge #28.
Unlocked Challenge #29.
Unlocked Challenge #30.
Unlocked the power of RERUN.
Unlocked a new challenge.
Unlocked super special rocks.
Unlocked a new area.
They will charge you up... for a small fee.
Beat Greedier mode with Jacob and Esau.
Beat everything in Hard mode with Jacob and Esau.
Beat everything in Hard Mode as every character.
Beat Greed mode with Jacob and Esau.
Complete the final chapter with Jacob and Esau.
Complete the Corpse with Jacob and Esau.
Complete the Void with Jacob and Esau.
Defeat Mega Satan with Jacob and Esau.
Complete the Dark Room with Jacob and Esau.
Complete Sheol with Jacob and Esau.
Beat the Void with Bethany.
Beat everything in Hard mode with Bethany.
Complete the final chapter with Bethany.
Complete the Corpse with Bethany.
Complete the Corpse with Lilith.
Complete the final chapter with the Lost.
Complete the Corpse with the Lost.
Complete the final chapter with Samson.
Complete the Corpse with Samson.
Complete the final chapter with Lilith.
Complete the Corpse with Lazarus.
Complete the Chest with Jacob and Esau.
Complete the Cathedral with Jacob and Esau.
Complete ??? with Jacob and Esau.
Complete the Corpse with Judas.
Complete the final chapter with Magdalene.
Complete the Corpse with Magdalene.
Complete the final chapter with ???.
Complete the Corpse with Apollyon.
Complete the Corpse with the Forgotten.
Complete the final chapter with Cain.
Complete the Corpse with Eve.
Complete the Corpse with Cain.
Complete the Corpse with ???.
Complete the Corpse with Keeper.
Complete the Corpse with Eden.
Complete the final chapter with Keeper.
Complete the final chapter with Isaac.
Complete the Corpse with Isaac.
Beat the game in Hard mode with Jacob and Esau.
Complete Boss Rush with Jacob and Esau.
Make a new friend!
Complete the final chapter with Apollyon.
Complete the Chest with Bethany.
Complete the Cathedral with Bethany.
Complete the final chapter with the Forgotten.
Complete the final chapter with Lazarus.
Defeat Mega Satan with Bethany.
Complete the Dark Room with Bethany.
Complete ??? with Bethany.
Complete Boss Rush with Bethany.
Beat Greedier mode with Bethany.
Complete the final chapter with Eve.
Complete the final chapter with Judas.
Complete the final chapter with Eden.
Complete the final chapter with Azazel.
The other side is calling...
You are just like your father...
Where could it lead to?
Complete the Corpse with Azazel.
Kill 10 Battery Bums.
Beat Greed mode with Bethany.
Obtain 99 pennies. Then spend every single one of them.
Defeat all bosses in the Mines.
Kill Hornfel before he escapes!
Complete Sheol with Bethany.
Beat the game in Hard mode with Bethany.
Beat Hard mode as Lazarus without losing a life
Defeat Baby Plum 10 times.
Enter the Corpse...
Get that song out of her head.
Defeat all bosses in the Mausoleum.
Defeat all bosses in Downpour.
Complete ??? 3 times.
Kids shouldn't believe in fortunes...
Spend 40+ pennies in a single shop.