Full list of all 637 The Binding of Isaac: Rebirth achievements. It takes around 200 hours to unlock all of the achievements in the base game on Windows.
The base game contains 242 achievements, and there are 3 DLC packs containing 395 achievements.
111% now stop playing!
Unlocked a new item.
OMG!
Unlocked Challenge #11.
Unlocked Challenge #19.
Unlocked a new co-player baby.
Unlocked Challenge #4.
Unlocked even more bosses!
Alt stage to the womb.
Unlocked new bosses!
New boss in the basement!
Unlocked a new character.
You are the best!!
Unlocked new enemies!
New boss in the womb!
New boss in the caves!
Alt stage to the depths.
Donated 600 pennies to the shop.
New mode unlocked!
Built him out of meat cubes.
Alt stage to the caves.
Beat Chest or Dark Room without taking damage.
They are waiting.
Isaac now holds the D6!
Your future's past waits.
Unlocked Challenge #7.
Alt stage to the basement.
New boss in the depths!
Beat womb without taking damage.
Unlocked Challenge #9.
Beat caves without taking damage.
Beat depths without taking damage.
Donated 200 pennies to the shop.
Unlocked a new boss!
Beat basement without taking damage.
The game just got harder!
Donated 100 pennies to the shop.
Unlocked another miniboss!
Unlocked Challenge #6.
Unlocked Challenge #8.
You became Lord of the Flies.
Donated 20 pennies to the shop.
Unlocked Challenge #5.
Unlocked Challenge #10.
The horsemen are loose.
Unlocked Challenge #20.
Chapter 4 - The Womb unlocked.
Destroy 100 rocks.
Unlocked Challenge #23.
Unlocked Challenge #24.
Unlocked...
Unlocked a new starting item.
Nerd x 1000000
Unlocked Challenge #26.
Unlocked a secret.
Greed just got harder!
Unlocked Challenge #27.
Unlocked a new item
Unlocked a hidden chapter.
Unlocked Challenge #21.
Unlocked Challenge #22.
Unlocked Challenge #25.
Unlocked Challenge #28.
Unlocked Challenge #29.
Unlocked Challenge #30.
Unlocked the power of RERUN.
Unlocked a new challenge.
Unlocked a new area.
Unlocked super special rocks.
They will charge you up... for a small fee.
Kill 10 Battery Bums.
Make a new friend!
Complete the Chest with Jacob and Esau.
Beat everything in Hard mode with Jacob and Esau.
Beat everything in Hard Mode as every character.
Complete the Cathedral with Jacob and Esau.
Complete the Void with Jacob and Esau.
Defeat Mega Satan with Jacob and Esau.
Complete the Dark Room with Jacob and Esau.
Complete Sheol with Jacob and Esau.
Complete ??? with Jacob and Esau.
Complete the Corpse with Jacob and Esau.
Beat the game in Hard mode with Jacob and Esau.
Complete Boss Rush with Jacob and Esau.
Beat the Void with Bethany.
Beat everything in Hard mode with Bethany.
Complete the Chest with Bethany.
Complete the Cathedral with Bethany.
Defeat Mega Satan with Bethany.
Complete the Dark Room with Bethany.
Complete Sheol with Bethany.
Complete ??? with Bethany.
Complete the Corpse with Bethany.
Beat the game in Hard mode with Bethany.
Complete Boss Rush with Bethany.
Complete the Corpse with the Forgotten.
Complete the Corpse with Apollyon.
Complete the Corpse with Keeper.
Complete the Corpse with Lilith.
Complete the Corpse with the Lost.
Complete the Corpse with Eden.
Complete the Corpse with Lazarus.
Complete the Corpse with Azazel.
Complete the Corpse with Samson.
Complete the Corpse with Eve.
Complete the Corpse with ???.
Defeat Baby Plum 10 times.
Complete the Corpse with Judas.
Complete the Corpse with Cain.
Complete the Corpse with Magdalene.
Get that song out of her head.
Defeat all bosses in the Mausoleum.
Complete the final chapter with the Lost.
Complete the final chapter with the Forgotten.
Complete the final chapter with Lilith.
Complete the final chapter with Eden.
Complete the final chapter with Azazel.
Complete the final chapter with Samson.
Complete the final chapter with Eve.
Complete the final chapter with ???.
Complete the final chapter with Judas.
Complete the final chapter with Cain.
Complete the final chapter with Keeper.
Complete the final chapter with Apollyon.
Complete the final chapter with Jacob and Esau.
Complete the final chapter with Bethany.
Complete the final chapter with Magdalene.
Complete the final chapter with Isaac.
Beat Greed mode with Bethany.
Beat Greedier mode with Bethany.
Beat Hard mode as Lazarus without losing a life
Complete the final chapter with Lazarus.
The other side is calling...
Beat Greed mode with Jacob and Esau.
Beat Greedier mode with Jacob and Esau.
You are just like your father...
Complete the Corpse with Isaac.
Where could it lead to?
Enter the Corpse...
Defeat all bosses in Downpour.
Defeat all bosses in the Mines.
Kill Hornfel before he escapes!
Complete ??? 3 times.
Kids shouldn't believe in fortunes...
Obtain 99 pennies. Then spend every single one of them.
Spend 40+ pennies in a single shop.