Full list of all 637 The Binding of Isaac: Rebirth achievements. It takes around 200 hours to unlock all of the achievements in the base game on Windows.
The base game contains 242 achievements, and there are 3 DLC packs containing 395 achievements.
OMG!
111% now stop playing!
Unlocked a new item.
Unlocked a new co-player baby.
Donated 600 pennies to the shop.
Beat caves without taking damage.
Beat Chest or Dark Room without taking damage.
New mode unlocked!
Unlocked a new character.
Built him out of meat cubes.
Unlocked Challenge #11.
Unlocked even more bosses!
Alt stage to the womb.
Unlocked new bosses!
New boss in the womb!
You are the best!!
Unlocked Challenge #19.
Beat womb without taking damage.
Beat depths without taking damage.
Alt stage to the depths.
They are waiting.
Unlocked new enemies!
Donated 200 pennies to the shop.
Isaac now holds the D6!
Alt stage to the caves.
New boss in the caves!
Unlocked a new boss!
New boss in the depths!
Unlocked another miniboss!
Donated 100 pennies to the shop.
Your future's past waits.
Unlocked Challenge #4.
Unlocked Challenge #7.
Alt stage to the basement.
Unlocked Challenge #8.
You became Lord of the Flies.
New boss in the basement!
Unlocked Challenge #9.
Beat basement without taking damage.
The game just got harder!
Unlocked Challenge #6.
Chapter 4 - The Womb unlocked.
The horsemen are loose.
Unlocked Challenge #20.
Donated 20 pennies to the shop.
Unlocked Challenge #5.
Unlocked Challenge #10.
Destroy 100 rocks.
Unlocked...
Unlocked a new starting item.
Nerd x 1000000
Unlocked a new item
Unlocked a secret.
Unlocked Challenge #24.
Greed just got harder!
Unlocked Challenge #27.
Unlocked Challenge #26.
Unlocked Challenge #23.
Unlocked a hidden chapter.
Unlocked Challenge #21.
Unlocked Challenge #22.
Unlocked Challenge #25.
Unlocked Challenge #28.
Unlocked Challenge #29.
Unlocked Challenge #30.
Unlocked super special rocks.
Unlocked the power of RERUN.
Unlocked a new challenge.
Unlocked a new area.
They will charge you up... for a small fee.
Complete the final chapter with Keeper.
Beat everything in Hard Mode as every character.
Complete the Corpse with Keeper.
Beat everything in Hard mode with Jacob and Esau.
Complete the final chapter with Jacob and Esau.
Complete the final chapter with Apollyon.
Complete the Corpse with Jacob and Esau.
Complete the Corpse with Apollyon.
Complete the final chapter with the Lost.
Complete the Dark Room with Jacob and Esau.
Complete Sheol with Jacob and Esau.
Complete ??? with Jacob and Esau.
Complete the Corpse with the Lost.
Beat Greed mode with Jacob and Esau.
Beat Greedier mode with Jacob and Esau.
Complete the final chapter with Lilith.
Complete the Corpse with Lilith.
Complete the Void with Jacob and Esau.
Complete Boss Rush with Jacob and Esau.
Complete the Corpse with Eden.
Complete the final chapter with Eden.
Complete the Corpse with the Forgotten.
Complete the final chapter with Lazarus.
Complete the Corpse with Lazarus.
Complete the final chapter with Samson.
Complete the Corpse with Samson.
Complete the final chapter with Eve.
Complete the Corpse with Eve.
Complete the final chapter with the Forgotten.
Defeat Mega Satan with Jacob and Esau.
Complete the Chest with Jacob and Esau.
Complete the Cathedral with Jacob and Esau.
Beat the game in Hard mode with Jacob and Esau.
Complete the Corpse with ???.
Complete the final chapter with ???.
Beat everything in Hard mode with Bethany.
Complete the Corpse with Bethany.
Defeat Mega Satan with Bethany.
Complete the final chapter with Bethany.
Complete the Dark Room with Bethany.
Complete Sheol with Bethany.
Beat Greed mode with Bethany.
Beat Greedier mode with Bethany.
Beat the Void with Bethany.
Complete ??? with Bethany.
Complete the final chapter with Judas.
Complete the Corpse with Judas.
Complete the Corpse with Cain.
Complete the final chapter with Cain.
Defeat Baby Plum 10 times.
Complete the Corpse with Magdalene.
Complete the final chapter with Magdalene.
Obtain 99 pennies. Then spend every single one of them.
Complete the final chapter with Isaac.
Complete the Corpse with Isaac.
Make a new friend!
Kill 10 Battery Bums.
Get that song out of her head.
Complete the final chapter with Azazel.
The other side is calling...
You are just like your father...
Complete the Corpse with Azazel.
Where could it lead to?
Complete the Cathedral with Bethany.
Complete the Chest with Bethany.
Kids shouldn't believe in fortunes...
Beat the game in Hard mode with Bethany.
Complete Boss Rush with Bethany.
Spend 40+ pennies in a single shop.
Defeat all bosses in the Mausoleum.
Defeat all bosses in Downpour.
Enter the Corpse...
Beat Hard mode as Lazarus without losing a life
Defeat all bosses in the Mines.
Kill Hornfel before he escapes!
Complete ??? 3 times.