Full list of all 637 The Binding of Isaac: Rebirth achievements. It takes around 200 hours to unlock all of the achievements in the base game on Windows.
The base game contains 242 achievements, and there are 3 DLC packs containing 395 achievements.
OMG!
111% now stop playing!
Unlocked a new item.
Donated 600 pennies to the shop.
Unlocked a new co-player baby.
Unlocked a new character.
Beat womb without taking damage.
Unlocked even more bosses!
Alt stage to the womb.
Unlocked new bosses!
New mode unlocked!
Unlocked Challenge #11.
New boss in the womb!
Donated 200 pennies to the shop.
Beat depths without taking damage.
You are the best!!
Unlocked new enemies!
Unlocked Challenge #19.
Beat Chest or Dark Room without taking damage.
They are waiting.
Alt stage to the depths.
Unlocked a new boss!
New boss in the caves!
Alt stage to the caves.
Built him out of meat cubes.
Isaac now holds the D6!
New boss in the depths!
New boss in the basement!
Unlocked Challenge #4.
Unlocked Challenge #7.
Alt stage to the basement.
Your future's past waits.
You became Lord of the Flies.
Unlocked Challenge #9.
Donated 100 pennies to the shop.
Beat caves without taking damage.
The game just got harder!
Unlocked another miniboss!
Donated 20 pennies to the shop.
Unlocked Challenge #6.
Beat basement without taking damage.
Unlocked Challenge #8.
Unlocked Challenge #5.
Unlocked Challenge #10.
The horsemen are loose.
Unlocked Challenge #20.
Chapter 4 - The Womb unlocked.
Destroy 100 rocks.
Unlocked a new starting item.
Nerd x 1000000
Unlocked...
Unlocked a new item
Unlocked Challenge #24.
Unlocked a secret.
Greed just got harder!
Unlocked Challenge #26.
Unlocked Challenge #27.
Unlocked Challenge #23.
Unlocked a hidden chapter.
Unlocked Challenge #21.
Unlocked Challenge #22.
Unlocked Challenge #25.
Unlocked Challenge #28.
Unlocked Challenge #29.
Unlocked Challenge #30.
Unlocked super special rocks.
Unlocked the power of RERUN.
Unlocked a new challenge.
Unlocked a new area.
Complete the Corpse with the Forgotten.
Beat everything in Hard Mode as every character.
Make a new friend!
Complete the final chapter with the Forgotten.
Beat Greed mode with Jacob and Esau.
Beat Greedier mode with Jacob and Esau.
Beat everything in Hard mode with Jacob and Esau.
Complete the Dark Room with Jacob and Esau.
Complete ??? with Jacob and Esau.
Complete the final chapter with Jacob and Esau.
Complete the Corpse with Jacob and Esau.
Complete the Corpse with Keeper.
Complete the final chapter with the Lost.
Complete the Corpse with the Lost.
Complete the final chapter with Keeper.
Complete the Dark Room with Bethany.
Beat everything in Hard mode with Bethany.
Beat the Void with Bethany.
Complete ??? with Bethany.
Complete Sheol with Bethany.
Complete Boss Rush with Bethany.
Complete the Corpse with Bethany.
Complete Sheol with Jacob and Esau.
Beat Greedier mode with Bethany.
Beat Greed mode with Bethany.
Complete the Corpse with Apollyon.
Kill 10 Battery Bums.
Complete the final chapter with Apollyon.
Complete the Corpse with Lilith.
Complete the final chapter with Lilith.
Complete the final chapter with Lazarus.
Complete the Corpse with Lazarus.
Complete the Corpse with Samson.
Complete Boss Rush with Jacob and Esau.
Complete the Corpse with Eve.
Complete the final chapter with Eve.
Complete the Corpse with Judas.
Complete the final chapter with Cain.
Complete the Corpse with Cain.
Complete the Corpse with Magdalene.
Complete the final chapter with Magdalene.
Complete the final chapter with ???.
Complete the Corpse with ???.
Complete the Corpse with Eden.
Complete the final chapter with Eden.
Get that song out of her head.
Complete the Void with Jacob and Esau.
Defeat Mega Satan with Jacob and Esau.
Complete the final chapter with Azazel.
Complete the Chest with Jacob and Esau.
Complete the final chapter with Samson.
They will charge you up... for a small fee.
Complete the Cathedral with Jacob and Esau.
Beat the game in Hard mode with Jacob and Esau.
Defeat Mega Satan with Bethany.
Complete the Chest with Bethany.
Complete the Cathedral with Bethany.
Beat the game in Hard mode with Bethany.
Defeat Baby Plum 10 times.
Complete the final chapter with Bethany.
Complete the final chapter with Isaac.
Kids shouldn't believe in fortunes...
Complete the Corpse with Isaac.
Obtain 99 pennies. Then spend every single one of them.
Defeat all bosses in the Mausoleum.
Complete the final chapter with Judas.
The other side is calling...
Defeat all bosses in the Mines.
You are just like your father...
Where could it lead to?
Complete the Corpse with Azazel.
Enter the Corpse...
Kill Hornfel before he escapes!
Defeat all bosses in Downpour.
Beat Hard mode as Lazarus without losing a life
Spend 40+ pennies in a single shop.
Complete ??? 3 times.