Full list of all 637 The Binding of Isaac: Rebirth achievements. It takes around 200 hours to unlock all of the achievements in the base game on Windows.
The base game contains 242 achievements, and there are 4 DLC packs containing 395 achievements.
Unlocked a new item.
111% now stop playing!
OMG!
Unlocked a new co-player baby.
Unlocked a new character.
New mode unlocked!
Alt stage to the basement.
Alt stage to the caves.
Alt stage to the depths.
Alt stage to the womb.
Unlocked new bosses!
Unlocked even more bosses!
Unlocked new enemies!
Donated 600 pennies to the shop.
Unlocked Challenge #11.
Built him out of meat cubes.
You are the best!!
Beat depths without taking damage.
Isaac now holds the D6!
Beat Chest or Dark Room without taking damage.
New boss in the womb!
Unlocked Challenge #19.
They are waiting.
Unlocked Challenge #5.
Unlocked Challenge #10.
New boss in the caves!
Donated 200 pennies to the shop.
New boss in the depths!
Your future's past waits.
Unlocked Challenge #4.
Unlocked Challenge #7.
Beat womb without taking damage.
Unlocked Challenge #9.
New boss in the basement!
Donated 100 pennies to the shop.
Unlocked another miniboss!
The game just got harder!
Unlocked a new boss!
Beat caves without taking damage.
Beat basement without taking damage.
Unlocked Challenge #6.
You became Lord of the Flies.
Donated 20 pennies to the shop.
Destroy 100 rocks.
The horsemen are loose.
Unlocked Challenge #20.
Chapter 4 - The Womb unlocked.
Unlocked Challenge #8.
Unlocked...
Unlocked a new starting item.
Nerd x 1000000
Unlocked a new item
Unlocked a secret.
Greed just got harder!
Unlocked a hidden chapter.
Unlocked Challenge #21.
Unlocked Challenge #22.
Unlocked Challenge #23.
Unlocked Challenge #24.
Unlocked Challenge #25.
Unlocked Challenge #26.
Unlocked Challenge #27.
Unlocked Challenge #28.
Unlocked Challenge #29.
Unlocked Challenge #30.
Unlocked super special rocks.
Unlocked the power of RERUN.
Unlocked a new area.
Unlocked a new challenge.
Beat everything in Hard mode with Jacob and Esau.
Complete the final chapter with Jacob and Esau.
Beat everything in Hard Mode as every character.
Complete the final chapter with Bethany.
Complete the Corpse with Jacob and Esau.
Complete the final chapter with Lazarus.
Complete the Corpse with Lazarus.
Complete the Corpse with Apollyon.
Complete the final chapter with Samson.
Complete the final chapter with Eve.
Complete the Corpse with Eve.
Complete the final chapter with Magdalene.
Complete the Corpse with Magdalene.
Complete the final chapter with Apollyon.
Beat everything in Hard mode with Bethany.
Complete the Corpse with Bethany.
Complete the Corpse with Keeper.
Complete the final chapter with ???.
Complete the Corpse with Samson.
Complete the final chapter with Azazel.
Beat the Void with Bethany.
Complete the Dark Room with Jacob and Esau.
Complete Sheol with Jacob and Esau.
Beat Greed mode with Jacob and Esau.
Beat Greedier mode with Jacob and Esau.
Complete the Void with Jacob and Esau.
Defeat Mega Satan with Jacob and Esau.
Complete the Chest with Jacob and Esau.
Complete the Cathedral with Jacob and Esau.
Complete ??? with Jacob and Esau.
Beat the game in Hard mode with Jacob and Esau.
Complete Boss Rush with Jacob and Esau.
Complete the final chapter with Judas.
Complete the Corpse with the Forgotten.
Complete the Corpse with Judas.
Complete the Corpse with ???.
Complete the final chapter with Cain.
Complete the final chapter with the Forgotten.
Complete the Corpse with the Lost.
Complete the final chapter with the Lost.
Complete the Corpse with Azazel.
Complete the final chapter with Lilith.
They will charge you up... for a small fee.
Complete the final chapter with Eden.
Complete the Corpse with Eden.
Complete the Dark Room with Bethany.
Kids shouldn't believe in fortunes...
Complete the final chapter with Keeper.
Complete the final chapter with Isaac.
Complete Sheol with Bethany.
Complete the Corpse with Lilith.
Complete the Corpse with Cain.
Get that song out of her head.
Make a new friend!
Beat Greed mode with Bethany.
Beat Greedier mode with Bethany.
The other side is calling...
You are just like your father...
Complete the Corpse with Isaac.
Where could it lead to?
Defeat all bosses in the Mausoleum.
Kill 10 Battery Bums.
Spend 40+ pennies in a single shop.
Defeat all bosses in the Mines.
Defeat Baby Plum 10 times.
Enter the Corpse...
Defeat all bosses in Downpour.
Defeat Mega Satan with Bethany.
Complete ??? with Bethany.
Complete Boss Rush with Bethany.
Complete the Chest with Bethany.
Complete the Cathedral with Bethany.
Beat the game in Hard mode with Bethany.
Beat Hard mode as Lazarus without losing a life
Obtain 99 pennies. Then spend every single one of them.
Kill Hornfel before he escapes!
Complete ??? 3 times.