Full list of all 637 The Binding of Isaac: Rebirth achievements. It takes around 200 hours to unlock all of the achievements in the base game on Windows.
The base game contains 242 achievements, and there are 3 DLC packs containing 395 achievements.
Unlocked a new item.
OMG!
111% now stop playing!
Built him out of meat cubes.
Unlocked a new co-player baby.
Donated 600 pennies to the shop.
New mode unlocked!
Beat Chest or Dark Room without taking damage.
Unlocked even more bosses!
Alt stage to the womb.
You became Lord of the Flies.
Unlocked Challenge #11.
New boss in the womb!
Unlocked new bosses!
Isaac now holds the D6!
You are the best!!
Alt stage to the depths.
Unlocked a new character.
Beat womb without taking damage.
Beat depths without taking damage.
New boss in the caves!
New boss in the basement!
Alt stage to the caves.
Unlocked a new boss!
Donated 200 pennies to the shop.
New boss in the depths!
Unlocked Challenge #4.
Unlocked Challenge #7.
Unlocked Challenge #19.
Alt stage to the basement.
Your future's past waits.
Unlocked Challenge #9.
Beat basement without taking damage.
They are waiting.
Unlocked new enemies!
Donated 100 pennies to the shop.
Unlocked Challenge #5.
Unlocked Challenge #10.
Beat caves without taking damage.
The game just got harder!
Unlocked Challenge #6.
Unlocked another miniboss!
Unlocked Challenge #8.
Donated 20 pennies to the shop.
The horsemen are loose.
Unlocked Challenge #20.
Chapter 4 - The Womb unlocked.
Destroy 100 rocks.
Nerd x 1000000
Unlocked...
Unlocked a new item
Unlocked a new starting item.
Unlocked a secret.
Unlocked Challenge #24.
Greed just got harder!
Unlocked Challenge #27.
Unlocked Challenge #26.
Unlocked Challenge #23.
Unlocked a hidden chapter.
Unlocked Challenge #21.
Unlocked Challenge #22.
Unlocked Challenge #25.
Unlocked Challenge #28.
Unlocked Challenge #29.
Unlocked Challenge #30.
Unlocked super special rocks.
Unlocked a new challenge.
Unlocked the power of RERUN.
Unlocked a new area.
They will charge you up... for a small fee.
Obtain 99 pennies. Then spend every single one of them.
Beat everything in Hard mode with Jacob and Esau.
Complete the Corpse with Jacob and Esau.
Beat everything in Hard Mode as every character.
Complete the Void with Jacob and Esau.
Complete ??? with Jacob and Esau.
Complete Boss Rush with Jacob and Esau.
Complete the final chapter with Jacob and Esau.
Complete the Dark Room with Jacob and Esau.
Complete Sheol with Jacob and Esau.
Beat Greed mode with Jacob and Esau.
Beat Greedier mode with Jacob and Esau.
Defeat Mega Satan with Jacob and Esau.
Complete the Chest with Jacob and Esau.
Complete the Cathedral with Jacob and Esau.
Beat the game in Hard mode with Jacob and Esau.
Beat everything in Hard mode with Bethany.
Complete the Corpse with Bethany.
Kids shouldn't believe in fortunes...
Complete ??? with Bethany.
Complete Boss Rush with Bethany.
Beat the Void with Bethany.
Complete the Dark Room with Bethany.
Complete Sheol with Bethany.
Beat Greed mode with Bethany.
Beat Greedier mode with Bethany.
Complete the final chapter with Apollyon.
Complete the Corpse with Apollyon.
Complete the Corpse with the Forgotten.
Complete the Corpse with Lilith.
Complete the Corpse with the Lost.
Complete the Corpse with Lazarus.
Complete the final chapter with Eden.
Complete the Corpse with Samson.
Complete the Corpse with Eden.
Complete the Corpse with ???.
Complete the final chapter with Cain.
Complete the Corpse with Cain.
Complete the Corpse with Magdalene.
Complete the Corpse with Keeper.
Complete the Corpse with Isaac.
Get that song out of her head.
Complete the final chapter with Lazarus.
Complete the final chapter with Samson.
Complete the final chapter with Lilith.
Complete the final chapter with Bethany.
Complete the final chapter with the Forgotten.
Complete the final chapter with Eve.
Complete the Corpse with Eve.
Complete the Corpse with Judas.
Spend 40+ pennies in a single shop.
Complete the final chapter with the Lost.
Complete the final chapter with ???.
Complete the final chapter with Magdalene.
Complete the final chapter with Keeper.
Complete the final chapter with Judas.
Defeat all bosses in the Mausoleum.
Kill 10 Battery Bums.
Complete the final chapter with Isaac.
Make a new friend!
Defeat Baby Plum 10 times.
Complete the final chapter with Azazel.
The other side is calling...
You are just like your father...
Complete the Corpse with Azazel.
Where could it lead to?
Enter the Corpse...
Defeat all bosses in the Mines.
Defeat all bosses in Downpour.
Kill Hornfel before he escapes!
Defeat Mega Satan with Bethany.
Complete the Chest with Bethany.
Complete the Cathedral with Bethany.
Beat the game in Hard mode with Bethany.
Beat Hard mode as Lazarus without losing a life
Complete ??? 3 times.