Full list of all 637 The Binding of Isaac: Rebirth achievements. It takes around 200 hours to unlock all of the achievements in the base game on Windows.
The base game contains 242 achievements, and there are 4 DLC packs containing 395 achievements.
111% now stop playing!
OMG!
Unlocked a new item.
New mode unlocked!
Unlocked a new co-player baby.
Unlocked a new character.
Donated 600 pennies to the shop.
You are the best!!
Unlocked new enemies!
Unlocked even more bosses!
Donated 200 pennies to the shop.
Unlocked Challenge #11.
Unlocked Challenge #19.
Isaac now holds the D6!
Alt stage to the womb.
Donated 100 pennies to the shop.
Beat Chest or Dark Room without taking damage.
New boss in the womb!
Built him out of meat cubes.
Unlocked new bosses!
You became Lord of the Flies.
New boss in the basement!
They are waiting.
Alt stage to the depths.
New boss in the caves!
Beat womb without taking damage.
Alt stage to the caves.
Unlocked a new boss!
New boss in the depths!
Unlocked Challenge #8.
Unlocked Challenge #4.
Unlocked Challenge #7.
Alt stage to the basement.
Your future's past waits.
Unlocked Challenge #9.
Unlocked another miniboss!
Beat depths without taking damage.
The game just got harder!
Beat caves without taking damage.
Beat basement without taking damage.
Unlocked Challenge #6.
Donated 20 pennies to the shop.
Destroy 100 rocks.
The horsemen are loose.
Unlocked Challenge #20.
Chapter 4 - The Womb unlocked.
Unlocked Challenge #5.
Unlocked Challenge #10.
Nerd x 1000000
Unlocked...
Unlocked a new starting item.
Unlocked a new item
Unlocked a secret.
Greed just got harder!
Unlocked Challenge #26.
Unlocked Challenge #24.
Unlocked Challenge #27.
Unlocked Challenge #23.
Unlocked a hidden chapter.
Unlocked Challenge #21.
Unlocked Challenge #22.
Unlocked Challenge #25.
Unlocked Challenge #28.
Unlocked Challenge #29.
Unlocked Challenge #30.
Unlocked super special rocks.
Unlocked the power of RERUN.
Unlocked a new challenge.
Unlocked a new area.
Beat everything in Hard mode with Jacob and Esau.
Beat everything in Hard Mode as every character.
Complete the final chapter with Jacob and Esau.
Complete the Corpse with Jacob and Esau.
Complete the final chapter with Apollyon.
Complete the Corpse with Apollyon.
Complete the Corpse with Keeper.
Complete the Corpse with Lilith.
They will charge you up... for a small fee.
Complete the final chapter with Lilith.
Complete the Corpse with the Lost.
Complete the final chapter with Keeper.
Kill 10 Battery Bums.
Complete the final chapter with the Lost.
Obtain 99 pennies. Then spend every single one of them.
Complete the final chapter with Eden.
Complete the Corpse with Eden.
Complete the Corpse with Lazarus.
Beat everything in Hard mode with Bethany.
Complete the final chapter with Bethany.
Complete the Corpse with the Forgotten.
Complete the final chapter with Lazarus.
Complete the final chapter with Samson.
Complete the Corpse with Samson.
Complete the Corpse with Eve.
Complete the final chapter with Eve.
Complete the final chapter with ???.
Complete the Corpse with ???.
Complete the final chapter with Judas.
Complete the Corpse with Judas.
Complete the Corpse with Cain.
Kids shouldn't believe in fortunes...
Complete the final chapter with Cain.
Complete the final chapter with Magdalene.
Complete the Corpse with Magdalene.
Complete the Corpse with Isaac.
Complete the final chapter with the Forgotten.
Complete the final chapter with Azazel.
Kill Hornfel before he escapes!
Complete the final chapter with Isaac.
The other side is calling...
Complete ??? with Jacob and Esau.
Complete Boss Rush with Jacob and Esau.
Complete the Dark Room with Jacob and Esau.
Complete Sheol with Jacob and Esau.
Beat Greedier mode with Jacob and Esau.
Beat Greed mode with Jacob and Esau.
Complete the Void with Jacob and Esau.
Defeat Mega Satan with Jacob and Esau.
Complete the Chest with Jacob and Esau.
Defeat Baby Plum 10 times.
Get that song out of her head.
Defeat all bosses in the Mausoleum.
Complete the Cathedral with Jacob and Esau.
Beat the game in Hard mode with Jacob and Esau.
Defeat all bosses in the Mines.
Defeat all bosses in Downpour.
You are just like your father...
Complete the Corpse with Azazel.
Where could it lead to?
Complete the Corpse with Bethany.
Enter the Corpse...
Make a new friend!
Beat the Void with Bethany.
Complete ??? with Bethany.
Complete the Chest with Bethany.
Beat Greed mode with Bethany.
Beat Greedier mode with Bethany.
Defeat Mega Satan with Bethany.
Spend 40+ pennies in a single shop.
Complete Boss Rush with Bethany.
Complete the Dark Room with Bethany.
Complete Sheol with Bethany.
Complete the Cathedral with Bethany.
Beat the game in Hard mode with Bethany.
Beat Hard mode as Lazarus without losing a life
Complete ??? 3 times.