Full list of all 637 The Binding of Isaac: Rebirth achievements. It takes around 200 hours to unlock all of the achievements in the base game on Windows.
The base game contains 242 achievements, and there are 4 DLC packs containing 395 achievements.
Unlocked a new item.
Unlocked Challenge #11.
Unlocked a new co-player baby.
Unlocked Challenge #4.
Unlocked even more bosses!
New boss in the womb!
Unlocked a new character.
Unlocked new bosses!
You are the best!!
Unlocked new enemies!
Beat Chest or Dark Room without taking damage.
Alt stage to the womb.
Beat depths without taking damage.
Unlocked Challenge #19.
They are waiting.
New mode unlocked!
Built him out of meat cubes.
Alt stage to the depths.
Isaac now holds the D6!
Alt stage to the caves.
New boss in the caves!
New boss in the basement!
Donated 600 pennies to the shop.
New boss in the depths!
Your future's past waits.
Unlocked Challenge #7.
Alt stage to the basement.
Unlocked a new boss!
Unlocked Challenge #9.
You became Lord of the Flies.
Unlocked Challenge #8.
The game just got harder!
Unlocked another miniboss!
Donated 200 pennies to the shop.
Unlocked Challenge #6.
Donated 100 pennies to the shop.
Beat caves without taking damage.
Beat womb without taking damage.
Beat basement without taking damage.
Donated 20 pennies to the shop.
Unlocked Challenge #5.
Unlocked Challenge #10.
Chapter 4 - The Womb unlocked.
The horsemen are loose.
Unlocked Challenge #20.
Destroy 100 rocks.
OMG!
111% now stop playing!
Unlocked...
Unlocked a new item
Unlocked Challenge #24.
Unlocked a new starting item.
Nerd x 1000000
Unlocked Challenge #26.
Unlocked Challenge #27.
Unlocked a secret.
Greed just got harder!
Unlocked Challenge #23.
Unlocked Challenge #29.
Unlocked a hidden chapter.
Unlocked Challenge #21.
Unlocked Challenge #22.
Unlocked Challenge #25.
Unlocked Challenge #28.
Unlocked Challenge #30.
Unlocked the power of RERUN.
Unlocked a new challenge.
Unlocked a new area.
Unlocked super special rocks.
Beat Greed mode with Jacob and Esau.
Beat Greedier mode with Jacob and Esau.
Beat everything in Hard mode with Jacob and Esau.
Beat everything in Hard Mode as every character.
Complete the final chapter with Jacob and Esau.
Complete the Corpse with Jacob and Esau.
Complete the Void with Jacob and Esau.
Defeat Mega Satan with Jacob and Esau.
Complete the Dark Room with Jacob and Esau.
Complete Sheol with Jacob and Esau.
Complete ??? with Jacob and Esau.
Complete the Corpse with Lazarus.
Complete the final chapter with Lazarus.
Complete the Chest with Jacob and Esau.
Complete the Cathedral with Jacob and Esau.
Beat the game in Hard mode with Jacob and Esau.
Complete Boss Rush with Jacob and Esau.
Complete the Corpse with Eve.
Complete the Corpse with Samson.
Complete the final chapter with ???.
Beat Greed mode with Bethany.
Beat Greedier mode with Bethany.
Beat everything in Hard mode with Bethany.
Complete the Corpse with Lilith.
Complete the Corpse with Bethany.
Complete the Dark Room with Bethany.
Beat the Void with Bethany.
Complete Boss Rush with Bethany.
Defeat Mega Satan with Bethany.
Complete the Chest with Bethany.
Complete the Corpse with Apollyon.
Complete Sheol with Bethany.
Complete ??? with Bethany.
Complete the final chapter with Eve.
Complete the final chapter with Apollyon.
Complete the Corpse with Eden.
Complete the final chapter with Eden.
Complete the Corpse with Cain.
Complete the final chapter with Cain.
Complete the Corpse with the Forgotten.
Complete the final chapter with the Forgotten.
Complete the Corpse with Magdalene.
Make a new friend!
Complete the final chapter with Keeper.
Complete the final chapter with Bethany.
Complete the Corpse with Azazel.
Complete the final chapter with Azazel.
Complete the Corpse with the Lost.
Complete the Corpse with Isaac.
Defeat Baby Plum 10 times.
Defeat all bosses in the Mines.
They will charge you up... for a small fee.
Complete the final chapter with Isaac.
Complete the final chapter with the Lost.
Get that song out of her head.
Complete the final chapter with Magdalene.
Complete the final chapter with Lilith.
Complete the final chapter with Samson.
Complete the Corpse with ???.
Kill 10 Battery Bums.
Complete the Corpse with Judas.
Defeat all bosses in the Mausoleum.
Complete the final chapter with Judas.
The other side is calling...
Complete the Cathedral with Bethany.
Beat the game in Hard mode with Bethany.
Beat Hard mode as Lazarus without losing a life
You are just like your father...
Complete the Corpse with Keeper.
Where could it lead to?
Enter the Corpse...
Defeat all bosses in Downpour.
Kill Hornfel before he escapes!
Complete ??? 3 times.
Kids shouldn't believe in fortunes...
Obtain 99 pennies. Then spend every single one of them.
Spend 40+ pennies in a single shop.