Full list of all 637 The Binding of Isaac: Rebirth achievements. It takes around 200 hours to unlock all of the achievements in the base game on Windows.
The base game contains 242 achievements, and there are 4 DLC packs containing 395 achievements.
Unlocked a new item.
Unlocked a new character.
New mode unlocked!
Alt stage to the basement.
Alt stage to the caves.
Alt stage to the depths.
Alt stage to the womb.
Unlocked new bosses!
Unlocked even more bosses!
Unlocked new enemies!
OMG!
111% now stop playing!
Built him out of meat cubes.
Unlocked a new co-player baby.
Beat Chest or Dark Room without taking damage.
New boss in the womb!
Unlocked Challenge #11.
Donated 600 pennies to the shop.
You are the best!!
Isaac now holds the D6!
Unlocked Challenge #19.
Unlocked a new boss!
Unlocked Challenge #8.
Beat caves without taking damage.
They are waiting.
You became Lord of the Flies.
Beat depths without taking damage.
Your future's past waits.
Unlocked Challenge #4.
Unlocked Challenge #7.
New boss in the depths!
New boss in the caves!
Unlocked Challenge #9.
New boss in the basement!
Donated 200 pennies to the shop.
Beat womb without taking damage.
The game just got harder!
Unlocked Challenge #6.
Donated 100 pennies to the shop.
Unlocked another miniboss!
Unlocked Challenge #5.
Unlocked Challenge #10.
Donated 20 pennies to the shop.
Beat basement without taking damage.
Destroy 100 rocks.
Chapter 4 - The Womb unlocked.
The horsemen are loose.
Unlocked Challenge #20.
Nerd x 1000000
Unlocked...
Unlocked a new starting item.
Unlocked a new item
Unlocked a secret.
Greed just got harder!
Unlocked a hidden chapter.
Unlocked Challenge #21.
Unlocked Challenge #22.
Unlocked Challenge #23.
Unlocked Challenge #24.
Unlocked Challenge #25.
Unlocked Challenge #26.
Unlocked Challenge #27.
Unlocked Challenge #28.
Unlocked Challenge #29.
Unlocked Challenge #30.
Unlocked super special rocks.
Unlocked the power of RERUN.
Unlocked a new area.
Unlocked a new challenge.
Complete the final chapter with Lilith.
Complete the Corpse with the Lost.
Complete the final chapter with the Lost.
Complete the final chapter with Magdalene.
Complete the final chapter with Keeper.
Complete the final chapter with Judas.
Complete the final chapter with Apollyon.
Complete the Corpse with Apollyon.
Beat the Void with Bethany.
Beat everything in Hard mode with Bethany.
Complete the Dark Room with Jacob and Esau.
Complete Sheol with Jacob and Esau.
Complete Boss Rush with Jacob and Esau.
They will charge you up... for a small fee.
Obtain 99 pennies. Then spend every single one of them.
Complete the final chapter with Azazel.
Complete the Corpse with Azazel.
Complete the Corpse with Eden.
Get that song out of her head.
Defeat Mega Satan with Bethany.
Complete the final chapter with Bethany.
Complete the final chapter with Cain.
Complete the Corpse with Cain.
Complete the Cathedral with Jacob and Esau.
Complete the Chest with Jacob and Esau.
Beat the game in Hard mode with Jacob and Esau.
Complete the final chapter with Jacob and Esau.
Complete ??? with Bethany.
Kill 10 Battery Bums.
Complete Boss Rush with Bethany.
Beat Greed mode with Bethany.
Beat Greedier mode with Bethany.
Complete the final chapter with Samson.
Make a new friend!
Complete the final chapter with Eve.
Defeat Baby Plum 10 times.
Complete the Corpse with Isaac.
Complete the final chapter with Isaac.
Complete the final chapter with Eden.
Complete the Dark Room with Bethany.
Complete Sheol with Bethany.
The other side is calling...
Complete the Corpse with Judas.
Defeat all bosses in the Mines.
Kids shouldn't believe in fortunes...
Spend 40+ pennies in a single shop.
Kill Hornfel before he escapes!
Defeat all bosses in the Mausoleum.
Complete the Chest with Bethany.
Complete the Cathedral with Bethany.
You are just like your father...
Complete the Corpse with Bethany.
Where could it lead to?
Enter the Corpse...
Beat the game in Hard mode with Bethany.
Beat Hard mode as Lazarus without losing a life
Defeat all bosses in Downpour.
Complete ??? 3 times.
Beat Greed mode with Jacob and Esau.
Complete ??? with Jacob and Esau.
Beat Greedier mode with Jacob and Esau.
Complete the Void with Jacob and Esau.
Beat everything in Hard mode with Jacob and Esau.
Defeat Mega Satan with Jacob and Esau.
Complete the Corpse with Magdalene.
Complete the Corpse with ???.
Complete the final chapter with ???.
Complete the Corpse with Eve.
Complete the Corpse with Samson.
Complete the Corpse with Lazarus.
Complete the final chapter with Lazarus.
Complete the Corpse with Lilith.
Complete the Corpse with Keeper.
Complete the Corpse with the Forgotten.
Complete the final chapter with the Forgotten.
Complete the Corpse with Jacob and Esau.
Beat everything in Hard Mode as every character.