Full list of all 637 The Binding of Isaac: Rebirth achievements. It takes around 200 hours to unlock all of the achievements in the base game on Windows.
The base game contains 242 achievements, and there are 3 DLC packs containing 395 achievements.
111% now stop playing!
Unlocked a new item.
OMG!
Beat Chest or Dark Room without taking damage.
Unlocked a new co-player baby.
Beat depths without taking damage.
Unlocked Challenge #11.
New mode unlocked!
Built him out of meat cubes.
Isaac now holds the D6!
Unlocked even more bosses!
Unlocked a new character.
Unlocked new enemies!
Alt stage to the basement.
Alt stage to the caves.
Alt stage to the depths.
Alt stage to the womb.
Unlocked new bosses!
New boss in the womb!
You are the best!!
Unlocked Challenge #19.
You became Lord of the Flies.
Beat womb without taking damage.
They are waiting.
Unlocked a new boss!
Beat caves without taking damage.
Donated 600 pennies to the shop.
New boss in the caves!
New boss in the depths!
Your future's past waits.
Unlocked Challenge #4.
Unlocked Challenge #7.
Unlocked Challenge #9.
The game just got harder!
Donated 200 pennies to the shop.
New boss in the basement!
Unlocked Challenge #8.
Unlocked Challenge #6.
Unlocked another miniboss!
Beat basement without taking damage.
Donated 100 pennies to the shop.
Unlocked Challenge #5.
Unlocked Challenge #10.
Donated 20 pennies to the shop.
Chapter 4 - The Womb unlocked.
The horsemen are loose.
Destroy 100 rocks.
Unlocked Challenge #20.
Nerd x 1000000
Unlocked a new starting item.
Unlocked...
Unlocked a secret.
Unlocked a new item
Greed just got harder!
Unlocked a hidden chapter.
Unlocked Challenge #21.
Unlocked Challenge #22.
Unlocked Challenge #23.
Unlocked Challenge #24.
Unlocked Challenge #25.
Unlocked Challenge #26.
Unlocked Challenge #27.
Unlocked Challenge #28.
Unlocked Challenge #29.
Unlocked Challenge #30.
Unlocked the power of RERUN.
Unlocked super special rocks.
Unlocked a new area.
Unlocked a new challenge.
Complete the Void with Jacob and Esau.
Beat everything in Hard mode with Jacob and Esau.
Beat everything in Hard Mode as every character.
Complete the final chapter with Keeper.
Complete the Corpse with Keeper.
Complete the final chapter with the Lost.
Beat Greed mode with Jacob and Esau.
Beat Greedier mode with Jacob and Esau.
Complete the Corpse with the Lost.
Complete the final chapter with Jacob and Esau.
Defeat Mega Satan with Jacob and Esau.
Complete the Corpse with Jacob and Esau.
Complete ??? with Jacob and Esau.
Complete Boss Rush with Jacob and Esau.
Complete the Dark Room with Jacob and Esau.
Complete Sheol with Jacob and Esau.
Beat everything in Hard mode with Bethany.
Complete the Corpse with Bethany.
Obtain 99 pennies. Then spend every single one of them.
Beat the Void with Bethany.
Complete ??? with Bethany.
Complete Boss Rush with Bethany.
Complete the final chapter with Bethany.
They will charge you up... for a small fee.
Complete the final chapter with ???.
Complete the Corpse with ???.
Complete the final chapter with Eden.
Complete the Corpse with Eden.
Complete the final chapter with the Forgotten.
Complete the Corpse with the Forgotten.
Complete the final chapter with Apollyon.
Complete the Corpse with Apollyon.
Complete the final chapter with Lilith.
Complete the Corpse with Lilith.
Complete the final chapter with Lazarus.
Complete the Corpse with Lazarus.
Complete the final chapter with Samson.
Complete the Corpse with Samson.
Complete the final chapter with Eve.
Complete the Corpse with Cain.
Complete the final chapter with Magdalene.
Complete the Corpse with Eve.
Complete the Chest with Jacob and Esau.
Complete the Cathedral with Jacob and Esau.
Beat the game in Hard mode with Jacob and Esau.
Complete the final chapter with Judas.
Complete the final chapter with Cain.
Kids shouldn't believe in fortunes...
Make a new friend!
Complete the final chapter with Isaac.
Kill 10 Battery Bums.
Complete the Corpse with Azazel.
Beat Greed mode with Bethany.
Beat Greedier mode with Bethany.
Complete the final chapter with Azazel.
The other side is calling...
Complete the Corpse with Magdalene.
Complete the Dark Room with Bethany.
Complete Sheol with Bethany.
Defeat Baby Plum 10 times.
Spend 40+ pennies in a single shop.
Complete the Corpse with Isaac.
Get that song out of her head.
Defeat Mega Satan with Bethany.
Complete the Chest with Bethany.
Complete the Cathedral with Bethany.
Beat the game in Hard mode with Bethany.
Kill Hornfel before he escapes!
You are just like your father...
Where could it lead to?
Complete the Corpse with Judas.
Defeat all bosses in the Mausoleum.
Defeat all bosses in the Mines.
Enter the Corpse...
Beat Hard mode as Lazarus without losing a life
Defeat all bosses in Downpour.
Complete ??? 3 times.