Full list of all 637 The Binding of Isaac: Rebirth achievements. It takes around 200 hours to unlock all of the achievements in the base game on Windows.
The base game contains 242 achievements, and there are 4 DLC packs containing 395 achievements.
OMG!
111% now stop playing!
Unlocked a new item.
Beat Chest or Dark Room without taking damage.
Beat womb without taking damage.
Unlocked a new co-player baby.
New mode unlocked!
Unlocked Challenge #11.
Donated 600 pennies to the shop.
Beat caves without taking damage.
Donated 200 pennies to the shop.
Built him out of meat cubes.
Beat depths without taking damage.
Unlocked a new character.
You are the best!!
Unlocked new enemies!
Alt stage to the womb.
Unlocked Challenge #19.
Unlocked even more bosses!
New boss in the womb!
Unlocked new bosses!
Alt stage to the basement.
They are waiting.
Alt stage to the depths.
Alt stage to the caves.
Isaac now holds the D6!
Unlocked a new boss!
Your future's past waits.
Unlocked Challenge #4.
Unlocked Challenge #7.
Unlocked Challenge #9.
Unlocked Challenge #8.
Donated 100 pennies to the shop.
You became Lord of the Flies.
New boss in the depths!
New boss in the caves!
The game just got harder!
Unlocked Challenge #6.
New boss in the basement!
Donated 20 pennies to the shop.
Unlocked another miniboss!
Chapter 4 - The Womb unlocked.
The horsemen are loose.
Unlocked Challenge #20.
Beat basement without taking damage.
Destroy 100 rocks.
Unlocked Challenge #5.
Unlocked Challenge #10.
Unlocked...
Unlocked a new starting item.
Unlocked a new item
Nerd x 1000000
Unlocked a secret.
Greed just got harder!
Unlocked Challenge #26.
Unlocked Challenge #24.
Unlocked Challenge #27.
Unlocked a hidden chapter.
Unlocked Challenge #22.
Unlocked Challenge #23.
Unlocked Challenge #25.
Unlocked Challenge #28.
Unlocked Challenge #29.
Unlocked Challenge #30.
Unlocked Challenge #21.
Unlocked super special rocks.
Unlocked a new area.
Unlocked the power of RERUN.
Unlocked a new challenge.
Beat Greed mode with Jacob and Esau.
Beat Greedier mode with Jacob and Esau.
Beat everything in Hard mode with Jacob and Esau.
Beat everything in Hard Mode as every character.
Complete the final chapter with Jacob and Esau.
Complete the Corpse with Jacob and Esau.
They will charge you up... for a small fee.
Complete ??? with Jacob and Esau.
Complete Boss Rush with Jacob and Esau.
Complete the final chapter with the Forgotten.
Complete the Corpse with the Forgotten.
Complete the final chapter with Apollyon.
Complete the Corpse with Apollyon.
Complete the final chapter with Keeper.
Complete the Corpse with Keeper.
Complete the Corpse with Lilith.
Complete the Corpse with the Lost.
Complete the final chapter with Eden.
Complete the Corpse with Eden.
Complete the final chapter with Samson.
Complete the Corpse with Samson.
Complete the final chapter with Eve.
Complete the Corpse with Eve.
Complete the Corpse with Lazarus.
Defeat Mega Satan with Jacob and Esau.
Complete the Dark Room with Jacob and Esau.
Complete Sheol with Jacob and Esau.
Beat everything in Hard mode with Bethany.
Complete the Corpse with Bethany.
Beat Greed mode with Bethany.
Beat Greedier mode with Bethany.
Defeat Mega Satan with Bethany.
Complete ??? with Bethany.
Complete Boss Rush with Bethany.
Beat the Void with Bethany.
Complete the Dark Room with Bethany.
Complete Sheol with Bethany.
Complete the final chapter with the Lost.
Complete the final chapter with Azazel.
Complete the Corpse with Azazel.
Complete the Corpse with ???.
Complete the final chapter with ???.
Complete the Corpse with Judas.
Complete the Corpse with Cain.
Complete the final chapter with Magdalene.
Complete the Corpse with Magdalene.
Complete the Void with Jacob and Esau.
Complete the Chest with Jacob and Esau.
Complete the Cathedral with Jacob and Esau.
Beat the game in Hard mode with Jacob and Esau.
Complete the Chest with Bethany.
Complete the Cathedral with Bethany.
Beat the game in Hard mode with Bethany.
Kill 10 Battery Bums.
Complete the final chapter with Bethany.
Complete the final chapter with Lilith.
Obtain 99 pennies. Then spend every single one of them.
Complete the final chapter with Lazarus.
Complete the final chapter with Judas.
Complete the final chapter with Cain.
Complete the final chapter with Isaac.
The other side is calling...
You are just like your father...
Complete the Corpse with Isaac.
Where could it lead to?
Enter the Corpse...
Get that song out of her head.
Defeat all bosses in the Mausoleum.
Make a new friend!
Beat Hard mode as Lazarus without losing a life
Kids shouldn't believe in fortunes...
Defeat all bosses in the Mines.
Defeat all bosses in Downpour.
Kill Hornfel before he escapes!
Complete ??? 3 times.
Spend 40+ pennies in a single shop.
Defeat Baby Plum 10 times.