Full list of all 637 The Binding of Isaac: Rebirth achievements. It takes around 200 hours to unlock all of the achievements in the base game on Windows.
The base game contains 242 achievements, and there are 4 DLC packs containing 395 achievements.
Unlocked a new item.
111% now stop playing!
OMG!
Unlocked Challenge #4.
Unlocked a new co-player baby.
Unlocked even more bosses!
Unlocked Challenge #8.
Unlocked Challenge #11.
Unlocked a new character.
New boss in the womb!
Beat Chest or Dark Room without taking damage.
Unlocked new bosses!
Isaac now holds the D6!
Alt stage to the womb.
New mode unlocked!
New boss in the basement!
Beat womb without taking damage.
Alt stage to the depths.
New boss in the caves!
Alt stage to the caves.
New boss in the depths!
You are the best!!
Donated 600 pennies to the shop.
Your future's past waits.
Unlocked Challenge #7.
Unlocked Challenge #19.
Alt stage to the basement.
Unlocked Challenge #9.
They are waiting.
Unlocked new enemies!
Unlocked a new boss!
Beat depths without taking damage.
The game just got harder!
Unlocked Challenge #6.
Built him out of meat cubes.
Unlocked another miniboss!
Donated 200 pennies to the shop.
You became Lord of the Flies.
Beat caves without taking damage.
Donated 100 pennies to the shop.
Unlocked Challenge #5.
Unlocked Challenge #10.
Donated 20 pennies to the shop.
The horsemen are loose.
Unlocked Challenge #20.
Chapter 4 - The Womb unlocked.
Beat basement without taking damage.
Destroy 100 rocks.
Unlocked...
Unlocked a new starting item.
Unlocked Challenge #24.
Unlocked Challenge #26.
Nerd x 1000000
Unlocked a new item
Unlocked Challenge #27.
Unlocked Challenge #23.
Unlocked Challenge #29.
Unlocked a hidden chapter.
Unlocked a secret.
Greed just got harder!
Unlocked Challenge #21.
Unlocked Challenge #22.
Unlocked Challenge #25.
Unlocked Challenge #28.
Unlocked Challenge #30.
Unlocked the power of RERUN.
Unlocked a new challenge.
Unlocked a new area.
Unlocked super special rocks.
Make a new friend!
Beat everything in Hard Mode as every character.
Complete the Corpse with Lazarus.
Complete the Corpse with Eden.
Complete the Corpse with Keeper.
Complete the Corpse with the Forgotten.
Complete the Corpse with Eve.
Complete the final chapter with ???.
Complete the Corpse with ???.
Complete the Corpse with Judas.
Complete the final chapter with Keeper.
Complete the final chapter with Judas.
Complete the final chapter with Lazarus.
Complete the final chapter with Samson.
Complete the Corpse with Samson.
Beat everything in Hard mode with Jacob and Esau.
Complete the Void with Jacob and Esau.
Complete the Chest with Jacob and Esau.
Complete the Corpse with Jacob and Esau.
Complete the Cathedral with Jacob and Esau.
Complete the Corpse with Cain.
Complete the Corpse with Magdalene.
Complete the final chapter with Magdalene.
Complete the final chapter with Isaac.
Complete the final chapter with Eden.
Complete the final chapter with the Lost.
Beat everything in Hard mode with Bethany.
Complete the Corpse with Bethany.
Defeat all bosses in the Mausoleum.
Complete the final chapter with Bethany.
Defeat Mega Satan with Bethany.
Complete the Dark Room with Bethany.
Complete ??? with Bethany.
Complete Boss Rush with Bethany.
Complete the final chapter with the Forgotten.
Complete the final chapter with Jacob and Esau.
Kill 10 Battery Bums.
Complete the final chapter with Eve.
Complete the final chapter with Azazel.
Complete the Corpse with Isaac.
Complete the Corpse with Azazel.
Defeat Baby Plum 10 times.
Defeat Mega Satan with Jacob and Esau.
Complete the Dark Room with Jacob and Esau.
Complete ??? with Jacob and Esau.
Beat the game in Hard mode with Jacob and Esau.
Complete Boss Rush with Jacob and Esau.
Complete Sheol with Jacob and Esau.
They will charge you up... for a small fee.
Complete the Corpse with Lilith.
Get that song out of her head.
Complete the final chapter with Lilith.
Complete the Corpse with the Lost.
Beat Greedier mode with Bethany.
Beat the Void with Bethany.
Complete the Chest with Bethany.
Complete the Cathedral with Bethany.
Defeat all bosses in the Mines.
Complete the final chapter with Cain.
Kill Hornfel before he escapes!
Complete the final chapter with Apollyon.
The other side is calling...
Beat Greed mode with Jacob and Esau.
Beat Greedier mode with Jacob and Esau.
Beat Greed mode with Bethany.
You are just like your father...
Where could it lead to?
Complete the Corpse with Apollyon.
Enter the Corpse...
Defeat all bosses in Downpour.
Complete ??? 3 times.
Complete Sheol with Bethany.
Beat the game in Hard mode with Bethany.
Kids shouldn't believe in fortunes...
Obtain 99 pennies. Then spend every single one of them.
Spend 40+ pennies in a single shop.
Beat Hard mode as Lazarus without losing a life