Full list of all 637 The Binding of Isaac: Rebirth achievements. It takes around 200 hours to unlock all of the achievements in the base game on Windows.
The base game contains 242 achievements, and there are 4 DLC packs containing 395 achievements.
Unlocked a new item.
OMG!
111% now stop playing!
Built him out of meat cubes.
Unlocked a new co-player baby.
Unlocked Challenge #4.
Unlocked even more bosses!
New boss in the womb!
Beat caves without taking damage.
Unlocked Challenge #8.
Beat womb without taking damage.
Unlocked new bosses!
Unlocked Challenge #11.
New mode unlocked!
Unlocked a new character.
You are the best!!
Unlocked Challenge #19.
Alt stage to the womb.
Beat Chest or Dark Room without taking damage.
They are waiting.
Unlocked new enemies!
Beat depths without taking damage.
Isaac now holds the D6!
Donated 600 pennies to the shop.
Alt stage to the depths.
Beat basement without taking damage.
Alt stage to the caves.
Your future's past waits.
Unlocked Challenge #7.
Alt stage to the basement.
Unlocked Challenge #9.
New boss in the depths!
New boss in the caves!
Unlocked a new boss!
New boss in the basement!
You became Lord of the Flies.
The game just got harder!
Donated 200 pennies to the shop.
Unlocked Challenge #6.
Unlocked another miniboss!
Donated 100 pennies to the shop.
Unlocked Challenge #5.
Unlocked Challenge #10.
The horsemen are loose.
Unlocked Challenge #20.
Chapter 4 - The Womb unlocked.
Destroy 100 rocks.
Donated 20 pennies to the shop.
Unlocked...
Unlocked a new starting item.
Nerd x 1000000
Unlocked a secret.
Unlocked Challenge #26.
Unlocked Challenge #27.
Unlocked Challenge #24.
Greed just got harder!
Unlocked a new item
Unlocked Challenge #23.
Unlocked a hidden chapter.
Unlocked Challenge #21.
Unlocked Challenge #22.
Unlocked Challenge #25.
Unlocked Challenge #28.
Unlocked Challenge #29.
Unlocked Challenge #30.
Unlocked the power of RERUN.
Unlocked a new challenge.
Unlocked super special rocks.
Unlocked a new area.
Beat everything in Hard mode with Jacob and Esau.
Beat everything in Hard Mode as every character.
Complete the Dark Room with Jacob and Esau.
Complete the Corpse with Jacob and Esau.
Complete Sheol with Jacob and Esau.
Beat Greed mode with Jacob and Esau.
Beat Greedier mode with Jacob and Esau.
Complete the Void with Jacob and Esau.
Defeat Mega Satan with Jacob and Esau.
Complete the Chest with Jacob and Esau.
Complete the Cathedral with Jacob and Esau.
Complete ??? with Jacob and Esau.
Complete Boss Rush with Jacob and Esau.
Beat the game in Hard mode with Jacob and Esau.
Complete the final chapter with the Lost.
Complete the final chapter with Lazarus.
Complete the Corpse with Lazarus.
Get that song out of her head.
Complete the Corpse with Eve.
Complete the final chapter with ???.
Complete the Corpse with the Lost.
Complete the final chapter with Eve.
Complete the final chapter with Magdalene.
Complete the Corpse with Magdalene.
Complete the Corpse with ???.
Complete the Corpse with Keeper.
Complete the Corpse with the Forgotten.
Complete the Corpse with Judas.
Complete the Corpse with Eden.
Complete the Corpse with Lilith.
Complete the final chapter with the Forgotten.
Complete the Corpse with Cain.
Complete the final chapter with Keeper.
Complete the final chapter with Lilith.
Complete the final chapter with Judas.
Complete the final chapter with Jacob and Esau.
Complete the final chapter with Apollyon.
Complete the Corpse with Azazel.
Complete the Corpse with Apollyon.
Complete the final chapter with Azazel.
They will charge you up... for a small fee.
Obtain 99 pennies. Then spend every single one of them.
Complete the Corpse with Samson.
Defeat all bosses in the Mausoleum.
Kill Hornfel before he escapes!
Beat the Void with Bethany.
Beat everything in Hard mode with Bethany.
Complete the final chapter with Eden.
Complete the final chapter with Cain.
Complete the final chapter with Samson.
Beat Greedier mode with Bethany.
Complete the final chapter with Bethany.
Kids shouldn't believe in fortunes...
Complete the Corpse with Bethany.
Complete the final chapter with Isaac.
The other side is calling...
Complete Boss Rush with Bethany.
You are just like your father...
Complete the Corpse with Isaac.
Where could it lead to?
Enter the Corpse...
Defeat all bosses in the Mines.
Defeat all bosses in Downpour.
Defeat Mega Satan with Bethany.
Complete the Chest with Bethany.
Complete the Dark Room with Bethany.
Complete ??? 3 times.
Complete ??? with Bethany.
Beat Greed mode with Bethany.
Complete the Cathedral with Bethany.
Complete Sheol with Bethany.
Kill 10 Battery Bums.
Defeat Baby Plum 10 times.
Beat the game in Hard mode with Bethany.
Beat Hard mode as Lazarus without losing a life
Spend 40+ pennies in a single shop.
Make a new friend!