Full list of all 637 The Binding of Isaac: Rebirth achievements. It takes around 200 hours to unlock all of the achievements in the base game on Windows.
The base game contains 242 achievements, and there are 4 DLC packs containing 395 achievements.
111% now stop playing!
OMG!
Unlocked a new item.
Unlocked Challenge #11.
Donated 600 pennies to the shop.
Unlocked a new co-player baby.
New mode unlocked!
Beat caves without taking damage.
Unlocked a new character.
Beat Chest or Dark Room without taking damage.
Unlocked even more bosses!
You are the best!!
Unlocked new enemies!
Unlocked Challenge #19.
Alt stage to the basement.
Alt stage to the caves.
Alt stage to the depths.
Alt stage to the womb.
Unlocked new bosses!
New boss in the womb!
Donated 200 pennies to the shop.
Donated 100 pennies to the shop.
They are waiting.
Beat womb without taking damage.
Isaac now holds the D6!
Unlocked a new boss!
Beat basement without taking damage.
New boss in the caves!
New boss in the basement!
Unlocked Challenge #4.
Built him out of meat cubes.
New boss in the depths!
Your future's past waits.
Unlocked Challenge #7.
You became Lord of the Flies.
Unlocked Challenge #9.
Unlocked Challenge #5.
Unlocked Challenge #10.
Unlocked another miniboss!
The game just got harder!
Unlocked Challenge #6.
Beat depths without taking damage.
Unlocked Challenge #8.
Donated 20 pennies to the shop.
Destroy 100 rocks.
Chapter 4 - The Womb unlocked.
The horsemen are loose.
Unlocked Challenge #20.
Nerd x 1000000
Unlocked...
Unlocked a new starting item.
Unlocked a new item
Unlocked a secret.
Greed just got harder!
Unlocked a hidden chapter.
Unlocked Challenge #21.
Unlocked Challenge #22.
Unlocked Challenge #23.
Unlocked Challenge #24.
Unlocked Challenge #25.
Unlocked Challenge #26.
Unlocked Challenge #27.
Unlocked Challenge #28.
Unlocked Challenge #29.
Unlocked Challenge #30.
Unlocked the power of RERUN.
Unlocked super special rocks.
Unlocked a new area.
Unlocked a new challenge.
Kids shouldn't believe in fortunes...
Beat the Void with Bethany.
Defeat Mega Satan with Bethany.
Complete Sheol with Bethany.
Complete the Chest with Bethany.
Defeat Baby Plum 10 times.
Beat Greed mode with Bethany.
Beat Greedier mode with Bethany.
Spend 40+ pennies in a single shop.
Complete the Cathedral with Bethany.
Complete Boss Rush with Bethany.
Beat the game in Hard mode with Bethany.
Defeat all bosses in the Mausoleum.
Beat Hard mode as Lazarus without losing a life
Enter the Corpse...
Defeat all bosses in the Mines.
Defeat all bosses in Downpour.
Kill Hornfel before he escapes!
Complete ??? 3 times.
You are just like your father...
Get that song out of her head.
Make a new friend!
The other side is calling...
Complete the Dark Room with Bethany.
Complete ??? with Bethany.
Beat everything in Hard mode with Bethany.
Beat the game in Hard mode with Jacob and Esau.
Complete the Cathedral with Jacob and Esau.
Complete Sheol with Jacob and Esau.
Complete the Chest with Jacob and Esau.
Complete the Dark Room with Jacob and Esau.
Complete Boss Rush with Jacob and Esau.
Beat Greed mode with Jacob and Esau.
Complete ??? with Jacob and Esau.
Beat Greedier mode with Jacob and Esau.
Complete the Void with Jacob and Esau.
Beat everything in Hard mode with Jacob and Esau.
Defeat Mega Satan with Jacob and Esau.
Complete the Corpse with Isaac.
Complete the final chapter with Isaac.
Complete the Corpse with Magdalene.
Complete the final chapter with Magdalene.
Complete the Corpse with Cain.
Complete the final chapter with Cain.
Complete the Corpse with Judas.
Complete the final chapter with Judas.
Complete the Corpse with ???.
Complete the final chapter with ???.
Complete the Corpse with Eve.
Complete the final chapter with Eve.
Complete the Corpse with Samson.
Complete the final chapter with Samson.
Complete the Corpse with Azazel.
Complete the final chapter with Azazel.
Complete the Corpse with Lazarus.
Complete the final chapter with Lazarus.
Complete the Corpse with Eden.
Complete the final chapter with Eden.
Complete the Corpse with the Lost.
Complete the final chapter with the Lost.
Complete the Corpse with Lilith.
Complete the final chapter with Lilith.
Complete the Corpse with Keeper.
Complete the final chapter with Keeper.
Complete the Corpse with Apollyon.
Complete the final chapter with Apollyon.
Complete the Corpse with the Forgotten.
Complete the final chapter with the Forgotten.
Complete the Corpse with Bethany.
Complete the final chapter with Bethany.
Complete the Corpse with Jacob and Esau.
Complete the final chapter with Jacob and Esau.
They will charge you up... for a small fee.
Kill 10 Battery Bums.
Beat everything in Hard Mode as every character.
Obtain 99 pennies. Then spend every single one of them.
Where could it lead to?