Full list of all 637 The Binding of Isaac: Rebirth achievements. It takes around 200 hours to unlock all of the achievements in the base game on Windows.
The base game contains 242 achievements, and there are 3 DLC packs containing 395 achievements.
Unlocked a new item.
Beat depths without taking damage.
New mode unlocked!
Built him out of meat cubes.
Unlocked Challenge #4.
Unlocked Challenge #11.
Unlocked even more bosses!
Unlocked new bosses!
Beat Chest or Dark Room without taking damage.
Unlocked a new co-player baby.
Unlocked a new character.
Beat caves without taking damage.
Unlocked Challenge #19.
New boss in the womb!
You are the best!!
Alt stage to the womb.
Alt stage to the depths.
Unlocked Challenge #8.
They are waiting.
Unlocked new enemies!
Alt stage to the caves.
Donated 600 pennies to the shop.
Isaac now holds the D6!
Unlocked Challenge #7.
Alt stage to the basement.
Your future's past waits.
Unlocked Challenge #9.
New boss in the caves!
Unlocked a new boss!
New boss in the depths!
The game just got harder!
Beat womb without taking damage.
Donated 200 pennies to the shop.
Beat basement without taking damage.
You became Lord of the Flies.
New boss in the basement!
Unlocked another miniboss!
Donated 100 pennies to the shop.
Unlocked Challenge #6.
Unlocked Challenge #5.
Unlocked Challenge #10.
Chapter 4 - The Womb unlocked.
The horsemen are loose.
Destroy 100 rocks.
Donated 20 pennies to the shop.
Unlocked Challenge #20.
OMG!
111% now stop playing!
Unlocked a new starting item.
Unlocked a new item
Nerd x 1000000
Unlocked a secret.
Greed just got harder!
Unlocked Challenge #24.
Unlocked Challenge #26.
Unlocked Challenge #27.
Unlocked Challenge #23.
Unlocked a hidden chapter.
Unlocked Challenge #21.
Unlocked Challenge #22.
Unlocked Challenge #25.
Unlocked Challenge #28.
Unlocked Challenge #29.
Unlocked Challenge #30.
Unlocked...
Unlocked super special rocks.
Unlocked a new area.
Unlocked a new challenge.
Unlocked the power of RERUN.
Complete the Corpse with Keeper.
Complete the Void with Jacob and Esau.
Complete the final chapter with Jacob and Esau.
Complete ??? with Jacob and Esau.
Complete the final chapter with Lazarus.
Complete the final chapter with Apollyon.
Complete the Corpse with Azazel.
Complete the final chapter with Azazel.
Complete the Corpse with Eden.
Complete the final chapter with Eden.
Complete the Corpse with Lilith.
Complete the final chapter with ???.
Complete the final chapter with Judas.
Complete the final chapter with Lilith.
Complete the Corpse with Eve.
Complete the Corpse with Isaac.
Complete the Corpse with Judas.
Complete the Corpse with Bethany.
Complete Boss Rush with Bethany.
Beat the Void with Bethany.
Defeat Mega Satan with Bethany.
Complete the final chapter with Bethany.
Beat Greed mode with Jacob and Esau.
Get that song out of her head.
Complete the final chapter with Magdalene.
Complete the final chapter with Cain.
The other side is calling...
Complete the final chapter with Isaac.
Complete the Corpse with Jacob and Esau.
Complete the Chest with Jacob and Esau.
Complete the Cathedral with Jacob and Esau.
Complete the Dark Room with Jacob and Esau.
Complete Sheol with Jacob and Esau.
Beat the game in Hard mode with Jacob and Esau.
You are just like your father...
Enter the Corpse...
Defeat all bosses in the Mausoleum.
Complete the Corpse with Cain.
Kill Hornfel before he escapes!
Where could it lead to?
Defeat all bosses in the Mines.
Complete ??? 3 times.
Defeat all bosses in Downpour.
Kill 10 Battery Bums.
Complete the Cathedral with Bethany.
Complete the Chest with Bethany.
Beat Greed mode with Bethany.
Defeat Baby Plum 10 times.
Beat the game in Hard mode with Bethany.
Complete Sheol with Bethany.
Complete the Dark Room with Bethany.
Beat Hard mode as Lazarus without losing a life
They will charge you up... for a small fee.
Kids shouldn't believe in fortunes...
Obtain 99 pennies. Then spend every single one of them.
Spend 40+ pennies in a single shop.
Make a new friend!
Complete ??? with Bethany.
Beat Greedier mode with Bethany.
Beat everything in Hard mode with Bethany.
Complete Boss Rush with Jacob and Esau.
Beat Greedier mode with Jacob and Esau.
Beat everything in Hard mode with Jacob and Esau.
Defeat Mega Satan with Jacob and Esau.
Complete the Corpse with Magdalene.
Complete the Corpse with ???.
Complete the final chapter with Eve.
Complete the Corpse with Samson.
Complete the final chapter with Samson.
Complete the Corpse with Lazarus.
Complete the Corpse with the Lost.
Complete the final chapter with the Lost.
Complete the final chapter with Keeper.
Complete the Corpse with Apollyon.
Complete the Corpse with the Forgotten.
Complete the final chapter with the Forgotten.
Beat everything in Hard Mode as every character.