Full list of all 637 The Binding of Isaac: Rebirth achievements. It takes around 200 hours to unlock all of the achievements in the base game on Windows.
The base game contains 242 achievements, and there are 3 DLC packs containing 395 achievements.
Unlocked a new item.
Unlocked a new character.
New mode unlocked!
Alt stage to the basement.
Alt stage to the caves.
Alt stage to the depths.
Alt stage to the womb.
Unlocked new bosses!
Unlocked even more bosses!
Unlocked new enemies!
111% now stop playing!
Unlocked a new co-player baby.
OMG!
Unlocked Challenge #11.
New boss in the womb!
Beat Chest or Dark Room without taking damage.
Unlocked Challenge #19.
You became Lord of the Flies.
Donated 600 pennies to the shop.
You are the best!!
Isaac now holds the D6!
Unlocked a new boss!
They are waiting.
New boss in the basement!
Beat caves without taking damage.
New boss in the caves!
Built him out of meat cubes.
Your future's past waits.
Beat womb without taking damage.
Unlocked Challenge #4.
Unlocked Challenge #7.
Unlocked Challenge #9.
New boss in the depths!
Unlocked Challenge #8.
Donated 200 pennies to the shop.
Beat basement without taking damage.
Donated 100 pennies to the shop.
The game just got harder!
Unlocked Challenge #6.
Unlocked another miniboss!
Unlocked Challenge #5.
Unlocked Challenge #10.
Chapter 4 - The Womb unlocked.
The horsemen are loose.
Beat depths without taking damage.
Unlocked Challenge #20.
Donated 20 pennies to the shop.
Destroy 100 rocks.
Nerd x 1000000
Unlocked...
Unlocked a new starting item.
Unlocked a new item
Unlocked a secret.
Unlocked Challenge #24.
Greed just got harder!
Unlocked Challenge #27.
Unlocked Challenge #26.
Unlocked Challenge #23.
Unlocked a hidden chapter.
Unlocked Challenge #21.
Unlocked Challenge #22.
Unlocked Challenge #25.
Unlocked Challenge #28.
Unlocked Challenge #29.
Unlocked Challenge #30.
Unlocked super special rocks.
Unlocked the power of RERUN.
Unlocked a new area.
Unlocked a new challenge.
They will charge you up... for a small fee.
Complete the Void with Jacob and Esau.
Beat everything in Hard mode with Jacob and Esau.
Beat everything in Hard Mode as every character.
Complete the Corpse with Jacob and Esau.
Beat Greed mode with Jacob and Esau.
Beat Greedier mode with Jacob and Esau.
Complete the final chapter with Jacob and Esau.
Defeat Mega Satan with Jacob and Esau.
Complete the Dark Room with Jacob and Esau.
Complete Sheol with Jacob and Esau.
Complete the Chest with Jacob and Esau.
Complete the Cathedral with Jacob and Esau.
Complete ??? with Jacob and Esau.
Beat the game in Hard mode with Jacob and Esau.
Complete the final chapter with the Lost.
Complete the Corpse with the Lost.
Kill 10 Battery Bums.
Complete the final chapter with Lilith.
Complete the Corpse with Lilith.
Complete the final chapter with Keeper.
Complete the Corpse with Keeper.
Beat everything in Hard mode with Bethany.
Complete the final chapter with Bethany.
Complete the Corpse with Bethany.
Complete the final chapter with the Forgotten.
Complete the Corpse with the Forgotten.
Complete the final chapter with Eden.
Complete the Corpse with Eden.
Complete the final chapter with Lazarus.
Complete the Corpse with Lazarus.
Complete the Corpse with Apollyon.
Complete the final chapter with Apollyon.
Complete the final chapter with ???.
Complete the Corpse with ???.
Complete the final chapter with Magdalene.
Complete the Corpse with Magdalene.
Complete the final chapter with Samson.
Complete the Corpse with Samson.
Make a new friend!
Complete the final chapter with Eve.
Complete the Corpse with Eve.
Complete the final chapter with Cain.
Complete the Corpse with Cain.
Complete the final chapter with Judas.
Complete the Corpse with Judas.
Complete Boss Rush with Jacob and Esau.
Beat the Void with Bethany.
Defeat Baby Plum 10 times.
Beat Greedier mode with Bethany.
Beat Greed mode with Bethany.
Obtain 99 pennies. Then spend every single one of them.
Spend 40+ pennies in a single shop.
Defeat Mega Satan with Bethany.
Complete the Dark Room with Bethany.
Complete Sheol with Bethany.
Complete the Chest with Bethany.
Complete the Cathedral with Bethany.
Complete ??? with Bethany.
Complete Boss Rush with Bethany.
Beat the game in Hard mode with Bethany.
Complete the final chapter with Isaac.
Kids shouldn't believe in fortunes...
Complete the Corpse with Azazel.
Beat Hard mode as Lazarus without losing a life
Complete the final chapter with Azazel.
The other side is calling...
You are just like your father...
Complete the Corpse with Isaac.
Where could it lead to?
Defeat all bosses in the Mausoleum.
Defeat all bosses in the Mines.
Defeat all bosses in Downpour.
Enter the Corpse...
Get that song out of her head.
Kill Hornfel before he escapes!
Complete ??? 3 times.