Full list of all 637 The Binding of Isaac: Rebirth achievements. It takes around 200 hours to unlock all of the achievements in the base game on Windows.
The base game contains 242 achievements, and there are 3 DLC packs containing 395 achievements.
Unlocked a new item.
Unlocked a new character.
New mode unlocked!
Alt stage to the basement.
Alt stage to the caves.
Alt stage to the depths.
Alt stage to the womb.
Unlocked new bosses!
Unlocked even more bosses!
Unlocked new enemies!
OMG!
111% now stop playing!
Unlocked Challenge #11.
Unlocked a new co-player baby.
Donated 600 pennies to the shop.
Beat Chest or Dark Room without taking damage.
Beat womb without taking damage.
Beat depths without taking damage.
Beat caves without taking damage.
Unlocked Challenge #19.
Built him out of meat cubes.
New boss in the womb!
You are the best!!
They are waiting.
Unlocked Challenge #8.
Isaac now holds the D6!
Your future's past waits.
Unlocked a new boss!
Unlocked Challenge #4.
Unlocked Challenge #7.
Unlocked Challenge #9.
You became Lord of the Flies.
Unlocked Challenge #5.
Unlocked Challenge #10.
New boss in the depths!
New boss in the caves!
Beat basement without taking damage.
The game just got harder!
Unlocked another miniboss!
Donated 200 pennies to the shop.
Unlocked Challenge #6.
New boss in the basement!
The horsemen are loose.
Unlocked Challenge #20.
Chapter 4 - The Womb unlocked.
Donated 100 pennies to the shop.
Donated 20 pennies to the shop.
Destroy 100 rocks.
Unlocked...
Unlocked a new starting item.
Nerd x 1000000
Unlocked a new item
Unlocked a secret.
Greed just got harder!
Unlocked a hidden chapter.
Unlocked Challenge #21.
Unlocked Challenge #22.
Unlocked Challenge #23.
Unlocked Challenge #24.
Unlocked Challenge #25.
Unlocked Challenge #26.
Unlocked Challenge #27.
Unlocked Challenge #28.
Unlocked Challenge #29.
Unlocked Challenge #30.
Unlocked the power of RERUN.
Unlocked super special rocks.
Unlocked a new area.
Unlocked a new challenge.
Complete the final chapter with Apollyon.
Beat everything in Hard Mode as every character.
Complete the Corpse with Apollyon.
Complete the Corpse with Lilith.
Complete the final chapter with Lazarus.
Complete the Corpse with Lazarus.
Complete the Corpse with the Lost.
Complete the final chapter with Azazel.
Complete the Corpse with Azazel.
Complete the final chapter with Eden.
Complete the Corpse with Eden.
Complete the final chapter with Samson.
Complete the Corpse with Samson.
Complete the Corpse with Eve.
Complete the final chapter with Eve.
Complete the Corpse with the Forgotten.
Beat the Void with Bethany.
Beat everything in Hard mode with Bethany.
Beat Greed mode with Jacob and Esau.
Beat Greedier mode with Jacob and Esau.
Beat everything in Hard mode with Jacob and Esau.
Complete the final chapter with Jacob and Esau.
Complete the Corpse with Jacob and Esau.
Complete the Dark Room with Jacob and Esau.
Complete Sheol with Jacob and Esau.
Complete the Void with Jacob and Esau.
Defeat Mega Satan with Jacob and Esau.
Complete the Chest with Jacob and Esau.
Complete the Cathedral with Jacob and Esau.
Complete ??? with Jacob and Esau.
Beat the game in Hard mode with Jacob and Esau.
Complete Boss Rush with Jacob and Esau.
Complete the Corpse with ???.
Complete the Dark Room with Bethany.
Complete Sheol with Bethany.
Complete the final chapter with ???.
Complete the Corpse with Judas.
Complete the final chapter with Bethany.
Beat Greed mode with Bethany.
Beat Greedier mode with Bethany.
Defeat Mega Satan with Bethany.
Complete the Chest with Bethany.
Complete ??? with Bethany.
Complete Boss Rush with Bethany.
Complete the Cathedral with Bethany.
Complete the Corpse with Magdalene.
Complete the final chapter with the Forgotten.
They will charge you up... for a small fee.
Complete the final chapter with Keeper.
Complete the final chapter with Lilith.
Complete the final chapter with the Lost.
Kill 10 Battery Bums.
Complete the final chapter with Judas.
Defeat Baby Plum 10 times.
Complete the final chapter with Cain.
Complete the Corpse with Cain.
Make a new friend!
Complete the final chapter with Magdalene.
Complete the Corpse with Bethany.
Beat the game in Hard mode with Bethany.
Complete the Corpse with Keeper.
Beat Hard mode as Lazarus without losing a life
Complete the final chapter with Isaac.
The other side is calling...
You are just like your father...
Complete the Corpse with Isaac.
Where could it lead to?
Get that song out of her head.
Defeat all bosses in the Mausoleum.
Defeat all bosses in the Mines.
Kids shouldn't believe in fortunes...
Obtain 99 pennies. Then spend every single one of them.
Enter the Corpse...
Spend 40+ pennies in a single shop.
Kill Hornfel before he escapes!
Defeat all bosses in Downpour.
Complete ??? 3 times.