Full list of all 637 The Binding of Isaac: Rebirth achievements. It takes around 200 hours to unlock all of the achievements in the base game on Windows.
The base game contains 242 achievements, and there are 4 DLC packs containing 395 achievements.
OMG!
111% now stop playing!
Unlocked a new item.
Beat Chest or Dark Room without taking damage.
Unlocked a new co-player baby.
New mode unlocked!
Unlocked a new character.
Donated 600 pennies to the shop.
Unlocked Challenge #11.
Built him out of meat cubes.
Unlocked even more bosses!
Beat caves without taking damage.
Unlocked new bosses!
New boss in the womb!
Beat womb without taking damage.
You are the best!!
Unlocked new enemies!
Alt stage to the womb.
Donated 200 pennies to the shop.
They are waiting.
Unlocked a new boss!
Alt stage to the depths.
Alt stage to the caves.
Isaac now holds the D6!
New boss in the caves!
Unlocked Challenge #5.
Unlocked Challenge #10.
You became Lord of the Flies.
Donated 100 pennies to the shop.
New boss in the depths!
Your future's past waits.
Unlocked Challenge #4.
Unlocked Challenge #7.
Unlocked Challenge #19.
Alt stage to the basement.
Unlocked Challenge #9.
New boss in the basement!
The game just got harder!
Unlocked Challenge #6.
Beat depths without taking damage.
Unlocked Challenge #8.
Donated 20 pennies to the shop.
Unlocked another miniboss!
The horsemen are loose.
Unlocked Challenge #20.
Chapter 4 - The Womb unlocked.
Beat basement without taking damage.
Destroy 100 rocks.
Nerd x 1000000
Unlocked a new starting item.
Unlocked...
Unlocked a secret.
Greed just got harder!
Unlocked a new item
Unlocked Challenge #26.
Unlocked Challenge #24.
Unlocked Challenge #27.
Unlocked Challenge #23.
Unlocked a hidden chapter.
Unlocked Challenge #21.
Unlocked Challenge #22.
Unlocked Challenge #25.
Unlocked Challenge #28.
Unlocked Challenge #29.
Unlocked Challenge #30.
Unlocked super special rocks.
Unlocked the power of RERUN.
Unlocked a new challenge.
Unlocked a new area.
Make a new friend!
Complete ??? with Jacob and Esau.
Beat everything in Hard mode with Jacob and Esau.
Beat everything in Hard Mode as every character.
Complete the Corpse with Jacob and Esau.
They will charge you up... for a small fee.
Complete the Void with Jacob and Esau.
Beat Greed mode with Jacob and Esau.
Beat Greedier mode with Jacob and Esau.
Defeat Mega Satan with Jacob and Esau.
Complete the Chest with Jacob and Esau.
Complete Boss Rush with Jacob and Esau.
Complete the Cathedral with Jacob and Esau.
Complete the Dark Room with Jacob and Esau.
Complete Sheol with Jacob and Esau.
Complete the Dark Room with Bethany.
Beat everything in Hard mode with Bethany.
Complete Sheol with Bethany.
Complete ??? with Bethany.
Beat Greed mode with Bethany.
Beat Greedier mode with Bethany.
Complete the Corpse with Bethany.
Beat the Void with Bethany.
Complete Boss Rush with Bethany.
Defeat Mega Satan with Bethany.
Complete the Chest with Bethany.
Complete the Cathedral with Bethany.
Beat the game in Hard mode with Bethany.
Complete the final chapter with Bethany.
Complete the final chapter with Jacob and Esau.
Beat the game in Hard mode with Jacob and Esau.
Complete the Corpse with the Lost.
Complete the Corpse with Magdalene.
Complete the final chapter with Magdalene.
Complete the final chapter with Eve.
Complete the Corpse with Eve.
Complete the Corpse with Judas.
Obtain 99 pennies. Then spend every single one of them.
Kill 10 Battery Bums.
Complete the final chapter with Judas.
Complete the final chapter with Samson.
Beat Hard mode as Lazarus without losing a life
Complete the Corpse with Samson.
Complete the final chapter with Azazel.
Kids shouldn't believe in fortunes...
Complete the Corpse with Azazel.
Complete the final chapter with Lazarus.
Complete the Corpse with Lazarus.
Complete the final chapter with Apollyon.
Complete the Corpse with Apollyon.
Complete the Corpse with the Forgotten.
Complete the final chapter with the Forgotten.
Complete the final chapter with Cain.
Complete the Corpse with Cain.
Complete the final chapter with Eden.
Complete the Corpse with Eden.
Complete the final chapter with Keeper.
Complete the Corpse with Keeper.
Complete the final chapter with Lilith.
Defeat Baby Plum 10 times.
Complete the Corpse with Lilith.
Complete the final chapter with Isaac.
Complete the Corpse with Isaac.
Spend 40+ pennies in a single shop.
Complete the final chapter with the Lost.
Complete the final chapter with ???.
The other side is calling...
Kill Hornfel before he escapes!
Defeat all bosses in the Mausoleum.
Get that song out of her head.
You are just like your father...
Complete the Corpse with ???.
Where could it lead to?
Enter the Corpse...
Defeat all bosses in the Mines.
Defeat all bosses in Downpour.
Complete ??? 3 times.