Full list of all 637 The Binding of Isaac: Rebirth achievements. It takes around 200 hours to unlock all of the achievements in the base game on Windows.
The base game contains 242 achievements, and there are 4 DLC packs containing 395 achievements.
Unlocked a new item.
OMG!
111% now stop playing!
Unlocked a new co-player baby.
New mode unlocked!
Unlocked a new character.
Unlocked new enemies!
Alt stage to the basement.
Alt stage to the caves.
Alt stage to the depths.
Alt stage to the womb.
Unlocked new bosses!
Unlocked even more bosses!
Beat caves without taking damage.
Beat depths without taking damage.
Beat womb without taking damage.
Unlocked Challenge #11.
Isaac now holds the D6!
Beat Chest or Dark Room without taking damage.
New boss in the womb!
You are the best!!
Donated 600 pennies to the shop.
Unlocked Challenge #19.
Unlocked a new boss!
They are waiting.
Donated 200 pennies to the shop.
Unlocked Challenge #4.
Your future's past waits.
Unlocked Challenge #7.
Built him out of meat cubes.
You became Lord of the Flies.
Unlocked Challenge #9.
New boss in the caves!
The game just got harder!
New boss in the depths!
New boss in the basement!
Unlocked Challenge #6.
Unlocked Challenge #8.
Unlocked another miniboss!
Chapter 4 - The Womb unlocked.
The horsemen are loose.
Beat basement without taking damage.
Destroy 100 rocks.
Donated 20 pennies to the shop.
Donated 100 pennies to the shop.
Unlocked Challenge #5.
Unlocked Challenge #10.
Unlocked Challenge #20.
Unlocked...
Unlocked a new starting item.
Unlocked a new item
Nerd x 1000000
Unlocked a secret.
Greed just got harder!
Unlocked a hidden chapter.
Unlocked Challenge #22.
Unlocked Challenge #23.
Unlocked Challenge #24.
Unlocked Challenge #25.
Unlocked Challenge #26.
Unlocked Challenge #27.
Unlocked Challenge #28.
Unlocked Challenge #29.
Unlocked Challenge #30.
Unlocked Challenge #21.
Unlocked the power of RERUN.
Unlocked super special rocks.
Unlocked a new area.
Unlocked a new challenge.
They will charge you up... for a small fee.
Make a new friend!
Beat everything in Hard mode with Jacob and Esau.
Defeat Mega Satan with Jacob and Esau.
Beat everything in Hard Mode as every character.
Complete the Chest with Jacob and Esau.
Complete the Cathedral with Jacob and Esau.
Complete the Corpse with Jacob and Esau.
Complete the Void with Jacob and Esau.
Complete the Dark Room with Jacob and Esau.
Complete Sheol with Jacob and Esau.
Complete ??? with Jacob and Esau.
Beat the game in Hard mode with Jacob and Esau.
Beat Greed mode with Jacob and Esau.
Beat Greedier mode with Jacob and Esau.
Complete the final chapter with Jacob and Esau.
Complete Boss Rush with Jacob and Esau.
Complete the Dark Room with Bethany.
Beat everything in Hard mode with Bethany.
Complete Sheol with Bethany.
Complete the final chapter with Bethany.
Beat the Void with Bethany.
Defeat Mega Satan with Bethany.
Complete the Chest with Bethany.
Complete the Cathedral with Bethany.
Complete ??? with Bethany.
Complete the Corpse with Bethany.
Beat the game in Hard mode with Bethany.
Complete Boss Rush with Bethany.
Beat Greedier mode with Bethany.
Beat Greed mode with Bethany.
Complete the final chapter with the Forgotten.
Complete the Corpse with the Forgotten.
Complete the final chapter with Apollyon.
Complete the Corpse with Apollyon.
Kill 10 Battery Bums.
Complete the final chapter with Keeper.
Complete the Corpse with Keeper.
Complete the final chapter with Lilith.
Complete the Corpse with Lilith.
Complete the Corpse with the Lost.
Complete the final chapter with the Lost.
Complete the final chapter with Eden.
Complete the Corpse with Eden.
Complete the final chapter with Lazarus.
Complete the Corpse with Lazarus.
Complete the final chapter with Azazel.
Complete the Corpse with Azazel.
Complete the final chapter with Samson.
Complete the Corpse with Samson.
Complete the final chapter with Eve.
Complete the Corpse with Eve.
Get that song out of her head.
Complete the final chapter with ???.
Complete the Corpse with ???.
Defeat all bosses in Downpour.
Complete the final chapter with Judas.
Complete the Corpse with Judas.
Complete the Corpse with Cain.
Kill Hornfel before he escapes!
Complete the final chapter with Cain.
Complete the final chapter with Magdalene.
Complete the Corpse with Magdalene.
Complete the final chapter with Isaac.
The other side is calling...
Beat Hard mode as Lazarus without losing a life
Defeat Baby Plum 10 times.
You are just like your father...
Where could it lead to?
Complete the Corpse with Isaac.
Defeat all bosses in the Mausoleum.
Enter the Corpse...
Defeat all bosses in the Mines.
Complete ??? 3 times.
Kids shouldn't believe in fortunes...
Obtain 99 pennies. Then spend every single one of them.
Spend 40+ pennies in a single shop.