Full list of all 637 The Binding of Isaac: Rebirth achievements. It takes around 200 hours to unlock all of the achievements in the base game on Windows.
The base game contains 242 achievements, and there are 3 DLC packs containing 395 achievements.
Unlocked a new item.
Unlocked a new character.
New mode unlocked!
Alt stage to the basement.
Alt stage to the caves.
Alt stage to the depths.
Alt stage to the womb.
Unlocked new bosses!
Unlocked even more bosses!
Unlocked new enemies!
Built him out of meat cubes.
OMG!
111% now stop playing!
Unlocked a new co-player baby.
Unlocked Challenge #11.
Beat Chest or Dark Room without taking damage.
Unlocked Challenge #19.
Donated 600 pennies to the shop.
Isaac now holds the D6!
New boss in the womb!
Beat womb without taking damage.
You are the best!!
They are waiting.
You became Lord of the Flies.
Donated 200 pennies to the shop.
Unlocked another miniboss!
Donated 100 pennies to the shop.
Your future's past waits.
Unlocked Challenge #4.
Unlocked Challenge #7.
Unlocked a new boss!
New boss in the caves!
Unlocked Challenge #9.
Beat depths without taking damage.
New boss in the depths!
Donated 20 pennies to the shop.
New boss in the basement!
The game just got harder!
Unlocked Challenge #8.
Unlocked Challenge #6.
Unlocked Challenge #5.
Unlocked Challenge #10.
Beat caves without taking damage.
The horsemen are loose.
Unlocked Challenge #20.
Chapter 4 - The Womb unlocked.
Beat basement without taking damage.
Destroy 100 rocks.
Nerd x 1000000
Unlocked...
Unlocked a new starting item.
Unlocked a secret.
Greed just got harder!
Unlocked a new item
Unlocked a hidden chapter.
Unlocked Challenge #21.
Unlocked Challenge #22.
Unlocked Challenge #23.
Unlocked Challenge #24.
Unlocked Challenge #25.
Unlocked Challenge #26.
Unlocked Challenge #27.
Unlocked Challenge #28.
Unlocked Challenge #29.
Unlocked Challenge #30.
Unlocked super special rocks.
Unlocked the power of RERUN.
Unlocked a new challenge.
Unlocked a new area.
They will charge you up... for a small fee.
Complete the Void with Jacob and Esau.
Beat everything in Hard mode with Jacob and Esau.
Beat everything in Hard Mode as every character.
Beat Greed mode with Jacob and Esau.
Beat Greedier mode with Jacob and Esau.
Complete the final chapter with Jacob and Esau.
Complete the Corpse with Jacob and Esau.
Complete the final chapter with Keeper.
Complete the Corpse with Lilith.
Complete the Corpse with ???.
Complete the Corpse with the Lost.
Defeat Mega Satan with Jacob and Esau.
Complete the Corpse with Keeper.
Complete the Dark Room with Jacob and Esau.
Complete Sheol with Jacob and Esau.
Complete the Corpse with Eve.
Complete the Corpse with Samson.
Complete the Corpse with Lazarus.
Complete the Corpse with the Forgotten.
Complete Boss Rush with Jacob and Esau.
Complete the final chapter with the Forgotten.
Complete the Corpse with Eden.
Complete the final chapter with Lazarus.
Complete the Chest with Jacob and Esau.
Complete the Cathedral with Jacob and Esau.
Complete the final chapter with Eve.
Complete the Corpse with Magdalene.
Complete the final chapter with Eden.
Complete the final chapter with Magdalene.
Complete the final chapter with Judas.
Beat everything in Hard mode with Bethany.
Defeat Mega Satan with Bethany.
Beat Greed mode with Bethany.
Beat Greedier mode with Bethany.
Kids shouldn't believe in fortunes...
Complete the Corpse with Bethany.
Complete the final chapter with Azazel.
Complete the Corpse with Apollyon.
Complete the Corpse with Isaac.
Complete the Corpse with Judas.
Complete ??? with Jacob and Esau.
Complete the final chapter with Bethany.
Complete the final chapter with the Lost.
Complete the final chapter with Lilith.
Complete the final chapter with Apollyon.
Obtain 99 pennies. Then spend every single one of them.
Complete the Corpse with Cain.
Beat the Void with Bethany.
Complete ??? with Bethany.
Complete the final chapter with Samson.
Complete the final chapter with ???.
Complete the final chapter with Cain.
Complete the final chapter with Isaac.
Make a new friend!
Defeat Baby Plum 10 times.
Kill 10 Battery Bums.
Beat the game in Hard mode with Jacob and Esau.
The other side is calling...
Defeat all bosses in the Mausoleum.
You are just like your father...
Complete the Corpse with Azazel.
Where could it lead to?
Defeat all bosses in Downpour.
Spend 40+ pennies in a single shop.
Defeat all bosses in the Mines.
Kill Hornfel before he escapes!
Enter the Corpse...
Complete the Dark Room with Bethany.
Complete Sheol with Bethany.
Complete Boss Rush with Bethany.
Complete the Chest with Bethany.
Complete the Cathedral with Bethany.
Beat the game in Hard mode with Bethany.
Beat Hard mode as Lazarus without losing a life
Get that song out of her head.
Complete ??? 3 times.