Full list of all 637 The Binding of Isaac: Rebirth achievements. It takes around 200 hours to unlock all of the achievements in the base game on Windows.
The base game contains 242 achievements, and there are 4 DLC packs containing 395 achievements.
OMG!
111% now stop playing!
Unlocked a new item.
Unlocked a new co-player baby.
Unlocked a new character.
Unlocked Challenge #11.
Beat Chest or Dark Room without taking damage.
Unlocked even more bosses!
Donated 600 pennies to the shop.
Unlocked new bosses!
New mode unlocked!
Alt stage to the basement.
Alt stage to the caves.
Alt stage to the depths.
Alt stage to the womb.
Unlocked new enemies!
You became Lord of the Flies.
Built him out of meat cubes.
New boss in the womb!
Unlocked Challenge #19.
Unlocked Challenge #8.
You are the best!!
They are waiting.
New boss in the caves!
New boss in the depths!
New boss in the basement!
Isaac now holds the D6!
Your future's past waits.
Unlocked Challenge #4.
Unlocked Challenge #7.
Unlocked another miniboss!
Unlocked a new boss!
Unlocked Challenge #9.
Donated 200 pennies to the shop.
The game just got harder!
Beat womb without taking damage.
Beat depths without taking damage.
Unlocked Challenge #6.
Donated 100 pennies to the shop.
Beat caves without taking damage.
Beat basement without taking damage.
Destroy 100 rocks.
Donated 20 pennies to the shop.
Chapter 4 - The Womb unlocked.
The horsemen are loose.
Unlocked Challenge #20.
Unlocked Challenge #5.
Unlocked Challenge #10.
Nerd x 1000000
Unlocked...
Unlocked Challenge #24.
Unlocked a new starting item.
Unlocked a new item
Unlocked a secret.
Greed just got harder!
Unlocked a hidden chapter.
Unlocked Challenge #22.
Unlocked Challenge #23.
Unlocked Challenge #25.
Unlocked Challenge #26.
Unlocked Challenge #27.
Unlocked Challenge #28.
Unlocked Challenge #29.
Unlocked Challenge #30.
Unlocked Challenge #21.
Unlocked super special rocks.
Unlocked a new area.
Unlocked the power of RERUN.
Unlocked a new challenge.
Beat everything in Hard mode with Jacob and Esau.
Beat everything in Hard Mode as every character.
Complete the final chapter with Jacob and Esau.
Complete the Corpse with Jacob and Esau.
Make a new friend!
Complete the Dark Room with Jacob and Esau.
Complete the Void with Jacob and Esau.
Complete ??? with Jacob and Esau.
Complete Boss Rush with Jacob and Esau.
Complete Sheol with Jacob and Esau.
Defeat Mega Satan with Jacob and Esau.
Complete the Chest with Jacob and Esau.
Complete the Cathedral with Jacob and Esau.
Beat the game in Hard mode with Jacob and Esau.
They will charge you up... for a small fee.
Complete the final chapter with the Lost.
Complete the Corpse with the Lost.
Complete the Corpse with Keeper.
Complete the final chapter with Keeper.
Complete the final chapter with Apollyon.
Complete the Corpse with Apollyon.
Complete the Corpse with the Forgotten.
Beat everything in Hard mode with Bethany.
Complete the final chapter with Bethany.
Complete the Corpse with Lilith.
Complete the final chapter with Lilith.
Complete the final chapter with Eden.
Kids shouldn't believe in fortunes...
Complete the Corpse with Eden.
Complete the Corpse with Lazarus.
Complete the final chapter with Lazarus.
Complete the Corpse with Azazel.
Complete the final chapter with Azazel.
Complete the final chapter with Samson.
Complete the Corpse with Samson.
Complete the final chapter with ???.
Kill 10 Battery Bums.
Complete the Corpse with ???.
Complete the Corpse with Cain.
Complete the final chapter with Magdalene.
Complete the Corpse with Magdalene.
Complete the Corpse with Eve.
Complete the final chapter with Eve.
Complete the final chapter with the Forgotten.
Complete the final chapter with Isaac.
Complete the final chapter with Cain.
Complete the final chapter with Judas.
The other side is calling...
Complete the Corpse with Isaac.
Complete the Dark Room with Bethany.
Complete Sheol with Bethany.
Complete ??? with Bethany.
Complete Boss Rush with Bethany.
Defeat Baby Plum 10 times.
Complete the Corpse with Judas.
Beat Greed mode with Bethany.
Beat Greedier mode with Bethany.
Beat Greed mode with Jacob and Esau.
Beat Greedier mode with Jacob and Esau.
Beat the Void with Bethany.
Defeat Mega Satan with Bethany.
Complete the Chest with Bethany.
You are just like your father...
Complete the Corpse with Bethany.
Where could it lead to?
Enter the Corpse...
Beat the game in Hard mode with Bethany.
Defeat all bosses in the Mausoleum.
Get that song out of her head.
Defeat all bosses in the Mines.
Kill Hornfel before he escapes!
Obtain 99 pennies. Then spend every single one of them.
Complete the Cathedral with Bethany.
Defeat all bosses in Downpour.
Beat Hard mode as Lazarus without losing a life
Spend 40+ pennies in a single shop.
Complete ??? 3 times.