Full list of all 637 The Binding of Isaac: Rebirth achievements. It takes around 200 hours to unlock all of the achievements in the base game on Windows.
The base game contains 242 achievements, and there are 4 DLC packs containing 395 achievements.
Unlocked a new item.
Alt stage to the womb.
Alt stage to the depths.
Alt stage to the caves.
Alt stage to the basement.
Unlocked new enemies!
Unlocked a new character.
New mode unlocked!
Unlocked even more bosses!
Unlocked new bosses!
OMG!
111% now stop playing!
Unlocked a new co-player baby.
Unlocked Challenge #11.
Built him out of meat cubes.
Donated 600 pennies to the shop.
Isaac now holds the D6!
New boss in the womb!
You became Lord of the Flies.
Beat Chest or Dark Room without taking damage.
Beat caves without taking damage.
You are the best!!
Beat womb without taking damage.
Beat depths without taking damage.
Unlocked Challenge #19.
They are waiting.
New boss in the caves!
New boss in the basement!
Donated 200 pennies to the shop.
New boss in the depths!
Unlocked another miniboss!
Unlocked a new boss!
Unlocked Challenge #4.
Unlocked Challenge #7.
Your future's past waits.
Unlocked Challenge #9.
Donated 100 pennies to the shop.
The game just got harder!
Donated 20 pennies to the shop.
Beat basement without taking damage.
Unlocked Challenge #6.
Unlocked Challenge #5.
Unlocked Challenge #10.
Destroy 100 rocks.
Unlocked Challenge #8.
Chapter 4 - The Womb unlocked.
The horsemen are loose.
Unlocked Challenge #20.
Nerd x 1000000
Unlocked...
Unlocked a new starting item.
Unlocked a secret.
Unlocked a new item
Greed just got harder!
Unlocked a hidden chapter.
Unlocked Challenge #21.
Unlocked Challenge #22.
Unlocked Challenge #23.
Unlocked Challenge #24.
Unlocked Challenge #25.
Unlocked Challenge #26.
Unlocked Challenge #27.
Unlocked Challenge #28.
Unlocked Challenge #29.
Unlocked Challenge #30.
Unlocked the power of RERUN.
Unlocked super special rocks.
Unlocked a new area.
Unlocked a new challenge.
Beat everything in Hard mode with Jacob and Esau.
Complete the final chapter with Jacob and Esau.
Beat everything in Hard Mode as every character.
Defeat Mega Satan with Jacob and Esau.
Complete the Corpse with Jacob and Esau.
Complete the Void with Jacob and Esau.
Complete ??? with Jacob and Esau.
Complete Boss Rush with Jacob and Esau.
Complete the Corpse with the Lost.
Complete the final chapter with the Lost.
Complete the Corpse with the Forgotten.
Complete the Corpse with Lilith.
Complete the Corpse with Magdalene.
Complete the final chapter with ???.
Complete the Corpse with Keeper.
Complete the final chapter with Keeper.
Beat everything in Hard mode with Bethany.
Complete ??? with Bethany.
Complete the final chapter with the Forgotten.
Kill 10 Battery Bums.
Beat Greed mode with Jacob and Esau.
Beat Greedier mode with Jacob and Esau.
Beat Greed mode with Bethany.
Beat Greedier mode with Bethany.
Complete the final chapter with Lilith.
Complete the final chapter with Magdalene.
Complete the final chapter with Judas.
Complete the final chapter with Samson.
Complete the final chapter with Lazarus.
Complete the final chapter with Eden.
Complete the final chapter with Eve.
Complete the final chapter with Apollyon.
They will charge you up... for a small fee.
Complete the final chapter with Bethany.
Kids shouldn't believe in fortunes...
Complete the final chapter with Cain.
Complete the final chapter with Azazel.
Complete the final chapter with Isaac.
The other side is calling...
Complete the Corpse with Judas.
Complete the Corpse with Lazarus.
Complete the Corpse with Apollyon.
Complete the Corpse with Eden.
Complete the Corpse with Samson.
Complete the Corpse with Cain.
Make a new friend!
Defeat Baby Plum 10 times.
Complete the Corpse with Eve.
Complete the Corpse with Azazel.
Defeat all bosses in the Mines.
Kill Hornfel before he escapes!
Defeat all bosses in Downpour.
Complete the Corpse with ???.
Get that song out of her head.
Defeat all bosses in the Mausoleum.
Complete the Corpse with Isaac.
Complete the Dark Room with Bethany.
Complete Sheol with Bethany.
Complete Boss Rush with Bethany.
Complete the Dark Room with Jacob and Esau.
Complete Sheol with Jacob and Esau.
Beat the Void with Bethany.
Defeat Mega Satan with Bethany.
Complete the Chest with Bethany.
Complete the Cathedral with Bethany.
Complete the Chest with Jacob and Esau.
Complete the Cathedral with Jacob and Esau.
Beat the game in Hard mode with Jacob and Esau.
You are just like your father...
Complete the Corpse with Bethany.
Where could it lead to?
Enter the Corpse...
Beat the game in Hard mode with Bethany.
Beat Hard mode as Lazarus without losing a life
Obtain 99 pennies. Then spend every single one of them.
Spend 40+ pennies in a single shop.
Complete ??? 3 times.