Full list of all 637 The Binding of Isaac: Rebirth achievements. It takes around 200 hours to unlock all of the achievements in the base game on Windows.
The base game contains 242 achievements, and there are 3 DLC packs containing 395 achievements.
Unlocked a new item.
Unlocked a new co-player baby.
Unlocked Challenge #4.
Unlocked a new character.
Beat depths without taking damage.
Beat Chest or Dark Room without taking damage.
Beat womb without taking damage.
Unlocked Challenge #11.
Unlocked Challenge #8.
New mode unlocked!
Isaac now holds the D6!
Unlocked even more bosses!
Beat caves without taking damage.
New boss in the womb!
Alt stage to the womb.
You are the best!!
Unlocked new enemies!
Unlocked new bosses!
Unlocked Challenge #19.
Donated 600 pennies to the shop.
They are waiting.
You became Lord of the Flies.
Alt stage to the depths.
Alt stage to the caves.
Unlocked a new boss!
Beat basement without taking damage.
New boss in the caves!
Your future's past waits.
Unlocked Challenge #7.
Alt stage to the basement.
Unlocked another miniboss!
New boss in the basement!
Unlocked Challenge #9.
New boss in the depths!
Donated 200 pennies to the shop.
The game just got harder!
Donated 100 pennies to the shop.
Unlocked Challenge #6.
Built him out of meat cubes.
Unlocked Challenge #5.
Unlocked Challenge #10.
Donated 20 pennies to the shop.
Chapter 4 - The Womb unlocked.
The horsemen are loose.
Unlocked Challenge #20.
Destroy 100 rocks.
OMG!
111% now stop playing!
Unlocked a new starting item.
Nerd x 1000000
Unlocked a secret.
Unlocked Challenge #26.
Greed just got harder!
Unlocked Challenge #27.
Unlocked Challenge #23.
Unlocked Challenge #24.
Unlocked a hidden chapter.
Unlocked Challenge #21.
Unlocked Challenge #22.
Unlocked Challenge #25.
Unlocked Challenge #28.
Unlocked Challenge #29.
Unlocked Challenge #30.
Unlocked a new item
Unlocked...
Unlocked the power of RERUN.
Unlocked a new challenge.
Unlocked a new area.
Unlocked super special rocks.
Complete the Corpse with Apollyon.
Complete the final chapter with Apollyon.
Complete the final chapter with Isaac.
Complete the final chapter with Jacob and Esau.
Complete the final chapter with Lazarus.
Complete the Corpse with Lazarus.
Beat the Void with Bethany.
Complete ??? with Bethany.
Complete Boss Rush with Bethany.
Beat Greed mode with Bethany.
Beat Greedier mode with Bethany.
Complete the final chapter with Azazel.
Complete the Corpse with Azazel.
Complete the Corpse with Isaac.
Beat Greed mode with Jacob and Esau.
Beat Greedier mode with Jacob and Esau.
Complete the Dark Room with Jacob and Esau.
Complete Sheol with Jacob and Esau.
Complete Boss Rush with Jacob and Esau.
Complete the final chapter with Lilith.
Complete the Corpse with Lilith.
Complete the final chapter with Magdalene.
Complete the Corpse with Judas.
Complete the final chapter with Judas.
Complete the final chapter with Keeper.
Complete the Corpse with Keeper.
Beat the game in Hard mode with Bethany.
Complete the Void with Jacob and Esau.
Complete the Chest with Jacob and Esau.
Complete the Cathedral with Jacob and Esau.
Beat the game in Hard mode with Jacob and Esau.
Complete the final chapter with the Forgotten.
Complete the Corpse with the Forgotten.
Complete the final chapter with Eden.
Complete the Corpse with Eden.
Complete the Corpse with Cain.
Complete the final chapter with Cain.
The other side is calling...
You are just like your father...
Complete the Corpse with Magdalene.
Where could it lead to?
Defeat all bosses in the Mines.
Enter the Corpse...
Defeat all bosses in the Mausoleum.
Get that song out of her head.
Kill Hornfel before he escapes!
Defeat all bosses in Downpour.
Complete ??? 3 times.
Beat Hard mode as Lazarus without losing a life
Kids shouldn't believe in fortunes...
Obtain 99 pennies. Then spend every single one of them.
Spend 40+ pennies in a single shop.
Defeat Baby Plum 10 times.
Make a new friend!
Complete the Cathedral with Bethany.
Complete Sheol with Bethany.
Complete the Chest with Bethany.
Complete the Dark Room with Bethany.
Beat everything in Hard mode with Bethany.
Defeat Mega Satan with Bethany.
Complete ??? with Jacob and Esau.
Beat everything in Hard mode with Jacob and Esau.
Defeat Mega Satan with Jacob and Esau.
Complete the Corpse with ???.
Complete the final chapter with ???.
Complete the Corpse with Eve.
Complete the final chapter with Eve.
Complete the Corpse with Samson.
Complete the final chapter with Samson.
Complete the Corpse with the Lost.
Complete the final chapter with the Lost.
Complete the Corpse with Bethany.
Complete the final chapter with Bethany.
Complete the Corpse with Jacob and Esau.
They will charge you up... for a small fee.
Kill 10 Battery Bums.
Beat everything in Hard Mode as every character.