Full list of all 637 The Binding of Isaac: Rebirth achievements. It takes around 200 hours to unlock all of the achievements in the base game on Windows.
The base game contains 242 achievements, and there are 4 DLC packs containing 395 achievements.
Unlocked a new item.
Unlocked a new character.
New mode unlocked!
Alt stage to the basement.
Alt stage to the caves.
Alt stage to the depths.
Alt stage to the womb.
Unlocked new bosses!
Unlocked even more bosses!
Unlocked new enemies!
OMG!
111% now stop playing!
Built him out of meat cubes.
Unlocked a new co-player baby.
Isaac now holds the D6!
Beat caves without taking damage.
Beat Chest or Dark Room without taking damage.
You became Lord of the Flies.
New boss in the womb!
Beat depths without taking damage.
Unlocked Challenge #11.
Unlocked Challenge #19.
Unlocked a new boss!
Donated 600 pennies to the shop.
You are the best!!
They are waiting.
New boss in the caves!
New boss in the depths!
Your future's past waits.
Unlocked Challenge #4.
Unlocked Challenge #7.
Unlocked Challenge #9.
New boss in the basement!
Beat womb without taking damage.
The game just got harder!
Unlocked Challenge #6.
Unlocked Challenge #5.
Unlocked Challenge #10.
Donated 200 pennies to the shop.
Beat basement without taking damage.
Unlocked Challenge #8.
Unlocked another miniboss!
Donated 100 pennies to the shop.
Destroy 100 rocks.
Chapter 4 - The Womb unlocked.
The horsemen are loose.
Unlocked Challenge #20.
Donated 20 pennies to the shop.
Nerd x 1000000
Unlocked...
Unlocked a new item
Unlocked a new starting item.
Unlocked a secret.
Greed just got harder!
Unlocked a hidden chapter.
Unlocked Challenge #21.
Unlocked Challenge #22.
Unlocked Challenge #23.
Unlocked Challenge #24.
Unlocked Challenge #25.
Unlocked Challenge #26.
Unlocked Challenge #27.
Unlocked Challenge #28.
Unlocked Challenge #29.
Unlocked Challenge #30.
Unlocked the power of RERUN.
Unlocked super special rocks.
Unlocked a new area.
Unlocked a new challenge.
Complete the final chapter with Apollyon.
Beat Greedier mode with Bethany.
Beat everything in Hard mode with Bethany.
Beat the Void with Bethany.
Complete the Corpse with Apollyon.
Complete the Corpse with Eden.
Complete the final chapter with Lazarus.
Complete the final chapter with Azazel.
Complete the Corpse with Bethany.
Complete the Corpse with ???.
Complete the final chapter with Cain.
Get that song out of her head.
Complete the final chapter with Bethany.
Kill 10 Battery Bums.
Complete the final chapter with Magdalene.
Complete the Chest with Bethany.
Complete ??? with Bethany.
Beat Greed mode with Bethany.
Complete Sheol with Jacob and Esau.
Complete the Corpse with Azazel.
Defeat Mega Satan with Bethany.
Complete the Dark Room with Bethany.
Complete Sheol with Bethany.
Complete Boss Rush with Bethany.
Complete the final chapter with Judas.
Obtain 99 pennies. Then spend every single one of them.
Complete the Corpse with Cain.
Complete the final chapter with Samson.
Complete the Cathedral with Jacob and Esau.
Beat the game in Hard mode with Jacob and Esau.
Complete Boss Rush with Jacob and Esau.
Complete the final chapter with ???.
Complete the final chapter with Eden.
Make a new friend!
Complete the final chapter with Isaac.
Complete the Cathedral with Bethany.
Defeat Baby Plum 10 times.
Complete the Corpse with Isaac.
The other side is calling...
Beat the game in Hard mode with Bethany.
Beat Hard mode as Lazarus without losing a life
You are just like your father...
Complete the Corpse with Judas.
Where could it lead to?
Enter the Corpse...
Defeat all bosses in the Mines.
Kill Hornfel before he escapes!
Spend 40+ pennies in a single shop.
Defeat all bosses in the Mausoleum.
Kids shouldn't believe in fortunes...
Defeat all bosses in Downpour.
Complete ??? 3 times.
Complete the Chest with Jacob and Esau.
Complete the Dark Room with Jacob and Esau.
Beat Greed mode with Jacob and Esau.
Complete ??? with Jacob and Esau.
Beat Greedier mode with Jacob and Esau.
Complete the Void with Jacob and Esau.
Beat everything in Hard mode with Jacob and Esau.
Defeat Mega Satan with Jacob and Esau.
Complete the Corpse with Magdalene.
Complete the Corpse with Eve.
Complete the final chapter with Eve.
Complete the Corpse with Samson.
Complete the Corpse with Lazarus.
Complete the Corpse with the Lost.
Complete the final chapter with the Lost.
Complete the Corpse with Lilith.
Complete the final chapter with Lilith.
Complete the Corpse with Keeper.
Complete the final chapter with Keeper.
Complete the Corpse with the Forgotten.
Complete the final chapter with the Forgotten.
Complete the Corpse with Jacob and Esau.
Complete the final chapter with Jacob and Esau.
They will charge you up... for a small fee.
Beat everything in Hard Mode as every character.