Full list of all 637 The Binding of Isaac: Rebirth achievements. It takes around 200 hours to unlock all of the achievements in the base game on Windows.
The base game contains 242 achievements, and there are 4 DLC packs containing 395 achievements.
Unlocked a new item.
Unlocked a new character.
New mode unlocked!
Unlocked new enemies!
Alt stage to the basement.
Alt stage to the caves.
Alt stage to the depths.
Alt stage to the womb.
Unlocked new bosses!
Unlocked even more bosses!
111% now stop playing!
OMG!
Beat Chest or Dark Room without taking damage.
Unlocked a new co-player baby.
Built him out of meat cubes.
Donated 600 pennies to the shop.
Beat depths without taking damage.
Beat caves without taking damage.
Unlocked Challenge #11.
You are the best!!
You became Lord of the Flies.
New boss in the womb!
Beat womb without taking damage.
Unlocked Challenge #19.
They are waiting.
Isaac now holds the D6!
New boss in the basement!
Unlocked a new boss!
New boss in the caves!
New boss in the depths!
Donated 200 pennies to the shop.
Your future's past waits.
Unlocked Challenge #4.
Unlocked Challenge #7.
Unlocked Challenge #8.
Unlocked Challenge #9.
Unlocked another miniboss!
Donated 100 pennies to the shop.
The game just got harder!
Unlocked Challenge #6.
Beat basement without taking damage.
Donated 20 pennies to the shop.
Destroy 100 rocks.
The horsemen are loose.
Unlocked Challenge #20.
Chapter 4 - The Womb unlocked.
Unlocked Challenge #5.
Unlocked Challenge #10.
Nerd x 1000000
Unlocked...
Unlocked a new starting item.
Unlocked a new item
Unlocked a secret.
Greed just got harder!
Unlocked a hidden chapter.
Unlocked Challenge #22.
Unlocked Challenge #23.
Unlocked Challenge #24.
Unlocked Challenge #25.
Unlocked Challenge #26.
Unlocked Challenge #27.
Unlocked Challenge #28.
Unlocked Challenge #29.
Unlocked Challenge #30.
Unlocked Challenge #21.
Unlocked super special rocks.
Unlocked a new area.
Unlocked the power of RERUN.
Unlocked a new challenge.
Make a new friend!
Kill 10 Battery Bums.
Beat everything in Hard Mode as every character.
Beat everything in Hard mode with Jacob and Esau.
Complete ??? with Jacob and Esau.
Complete the Corpse with the Forgotten.
Complete the final chapter with the Forgotten.
Complete the Void with Jacob and Esau.
Beat everything in Hard mode with Bethany.
Beat the Void with Bethany.
Complete ??? with Bethany.
Beat Greed mode with Jacob and Esau.
Beat Greedier mode with Jacob and Esau.
Complete the Corpse with the Lost.
Complete the final chapter with the Lost.
Complete the final chapter with Keeper.
Complete the final chapter with Lilith.
Complete the Dark Room with Jacob and Esau.
Complete Sheol with Jacob and Esau.
Complete the final chapter with ???.
Complete the final chapter with Eve.
Complete the final chapter with Eden.
Complete the final chapter with Jacob and Esau.
Defeat Mega Satan with Jacob and Esau.
Complete the Chest with Jacob and Esau.
Complete the Cathedral with Jacob and Esau.
Complete Boss Rush with Jacob and Esau.
Complete the final chapter with Azazel.
Complete the final chapter with Judas.
Complete the final chapter with Cain.
Complete the final chapter with Apollyon.
Complete the final chapter with Bethany.
Complete the final chapter with Lazarus.
Complete the final chapter with Samson.
Complete the final chapter with Isaac.
Complete the final chapter with Magdalene.
Complete the Corpse with Jacob and Esau.
Beat the game in Hard mode with Jacob and Esau.
Complete the Corpse with ???.
Complete the Corpse with Keeper.
Beat Greed mode with Bethany.
Beat Greedier mode with Bethany.
Complete the Corpse with Eden.
Complete the Corpse with Bethany.
Complete the Corpse with Lilith.
Complete the Corpse with Apollyon.
Complete the Corpse with Eve.
Complete the Corpse with Judas.
Complete the Corpse with Azazel.
Complete the Corpse with Lazarus.
Complete the Corpse with Magdalene.
Complete the Corpse with Samson.
Complete the Corpse with Isaac.
Defeat Baby Plum 10 times.
Defeat all bosses in the Mines.
The other side is calling...
You are just like your father...
Complete the Corpse with Cain.
Where could it lead to?
Enter the Corpse...
Complete the Dark Room with Bethany.
Complete Sheol with Bethany.
Complete Boss Rush with Bethany.
Defeat Mega Satan with Bethany.
Complete the Chest with Bethany.
Complete the Cathedral with Bethany.
Beat the game in Hard mode with Bethany.
Beat Hard mode as Lazarus without losing a life
They will charge you up... for a small fee.
Obtain 99 pennies. Then spend every single one of them.
Kids shouldn't believe in fortunes...
Kill Hornfel before he escapes!
Defeat all bosses in the Mausoleum.
Spend 40+ pennies in a single shop.
Get that song out of her head.
Defeat all bosses in Downpour.
Complete ??? 3 times.