Full list of all 637 The Binding of Isaac: Rebirth achievements. It takes around 200 hours to unlock all of the achievements in the base game on Windows.
The base game contains 242 achievements, and there are 4 DLC packs containing 395 achievements.
Unlocked a new item.
OMG!
111% now stop playing!
Unlocked Challenge #4.
Unlocked even more bosses!
Unlocked a new co-player baby.
New mode unlocked!
Unlocked a new character.
Beat Chest or Dark Room without taking damage.
Donated 600 pennies to the shop.
Alt stage to the womb.
New boss in the womb!
Unlocked new bosses!
Beat depths without taking damage.
You became Lord of the Flies.
Unlocked Challenge #11.
You are the best!!
Unlocked new enemies!
Unlocked Challenge #19.
Built him out of meat cubes.
Alt stage to the depths.
New boss in the basement!
Isaac now holds the D6!
New boss in the caves!
They are waiting.
Alt stage to the caves.
New boss in the depths!
Unlocked a new boss!
Unlocked Challenge #7.
Alt stage to the basement.
Your future's past waits.
Beat caves without taking damage.
Unlocked Challenge #9.
Beat womb without taking damage.
Unlocked Challenge #8.
Donated 200 pennies to the shop.
The game just got harder!
Unlocked Challenge #6.
Unlocked Challenge #5.
Unlocked Challenge #10.
Beat basement without taking damage.
Donated 100 pennies to the shop.
Unlocked another miniboss!
Donated 20 pennies to the shop.
The horsemen are loose.
Unlocked Challenge #20.
Chapter 4 - The Womb unlocked.
Destroy 100 rocks.
Unlocked...
Unlocked a new starting item.
Unlocked a new item
Nerd x 1000000
Unlocked a secret.
Greed just got harder!
Unlocked Challenge #26.
Unlocked Challenge #27.
Unlocked Challenge #23.
Unlocked Challenge #29.
Unlocked a hidden chapter.
Unlocked Challenge #24.
Unlocked Challenge #21.
Unlocked Challenge #22.
Unlocked Challenge #25.
Unlocked Challenge #28.
Unlocked Challenge #30.
Unlocked a new area.
Unlocked the power of RERUN.
Unlocked a new challenge.
Unlocked super special rocks.
Kill 10 Battery Bums.
They will charge you up... for a small fee.
Beat everything in Hard mode with Bethany.
Complete the final chapter with Bethany.
Beat everything in Hard Mode as every character.
Complete the Corpse with Bethany.
Complete the Chest with Bethany.
Complete the Cathedral with Bethany.
Complete the Chest with Jacob and Esau.
Beat everything in Hard mode with Jacob and Esau.
Complete the Cathedral with Jacob and Esau.
Complete the Corpse with Jacob and Esau.
Complete the final chapter with Magdalene.
Complete the final chapter with Cain.
Complete the Corpse with Cain.
Complete the final chapter with Judas.
Complete the Corpse with Judas.
Complete the final chapter with ???.
Complete the Corpse with ???.
Complete the final chapter with Eve.
Complete the final chapter with Jacob and Esau.
Complete the Corpse with Eve.
Complete the final chapter with Samson.
Make a new friend!
Complete the Corpse with Samson.
Complete the final chapter with Azazel.
Complete the Corpse with Azazel.
Complete the final chapter with Lazarus.
Complete the Corpse with Lazarus.
Complete the final chapter with Eden.
Complete the Corpse with Eden.
Complete the final chapter with Lilith.
Complete the Corpse with Lilith.
Complete the final chapter with Keeper.
Complete the Corpse with Keeper.
Complete the Corpse with Apollyon.
Defeat all bosses in the Mines.
Complete the final chapter with Apollyon.
Defeat all bosses in Downpour.
Defeat Mega Satan with Jacob and Esau.
Complete the Dark Room with Jacob and Esau.
Complete Sheol with Jacob and Esau.
Complete the final chapter with Isaac.
Complete the Corpse with Isaac.
Complete the final chapter with the Lost.
Complete the Corpse with the Lost.
Defeat Baby Plum 10 times.
Defeat Mega Satan with Bethany.
Complete the Dark Room with Bethany.
Complete Sheol with Bethany.
Beat the Void with Bethany.
Complete ??? with Bethany.
Complete Boss Rush with Bethany.
Complete the final chapter with the Forgotten.
The other side is calling...
Complete the Corpse with the Forgotten.
Defeat all bosses in the Mausoleum.
Complete the Void with Jacob and Esau.
Complete ??? with Jacob and Esau.
Beat the game in Hard mode with Jacob and Esau.
Complete Boss Rush with Jacob and Esau.
Beat Greed mode with Jacob and Esau.
Beat Greedier mode with Jacob and Esau.
You are just like your father...
Complete the Corpse with Magdalene.
Where could it lead to?
Enter the Corpse...
Get that song out of her head.
Kill Hornfel before he escapes!
Complete ??? 3 times.
Beat Greedier mode with Bethany.
Beat Greed mode with Bethany.
Obtain 99 pennies. Then spend every single one of them.
Kids shouldn't believe in fortunes...
Spend 40+ pennies in a single shop.
Beat the game in Hard mode with Bethany.
Beat Hard mode as Lazarus without losing a life